Miconazole Influence on Both Cellular Immune Response and Hepatic Drug Metabolism in Mice
Abstract Miconazole was found to exert a biphasic influence on both cellular immune response and hepatic drug metabolism in adult Swiss mice. Indeed, at the dose of 2.5 or 12.5 ma/kg/twice daily via intraperitoneal route, miconazole depressed delayed-type hypersensitivity (DTH) to sheep red blood ce...
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| Veröffentlicht in: | Immunopharmacology and immunotoxicology 1985, Vol.7 (2), p.171-178 |
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| container_title | Immunopharmacology and immunotoxicology |
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| creator | Descotes, J. AndrÉ, P. Tedone, R. Evreux, J. Cl |
| description | Abstract
Miconazole was found to exert a biphasic influence on both cellular immune response and hepatic drug metabolism in adult Swiss mice. Indeed, at the dose of 2.5 or 12.5 ma/kg/twice daily via intraperitoneal route, miconazole depressed delayed-type hypersensitivity (DTH) to sheep red blood cells and hepatic drug metabolism as determined from barbiturate sleeping time, following one-day treatment. By contrast, at the same dose level, miconazole enhanced DTH and hepatic drug metabolism after a five-day administration schedule. Primary humoral response and colloidal carbon clearance were not affected. Although the underlying mechanism remains to be fully elucidated, these findings clearly suggest a close relation between modulation of the cellular immune response and activity of liver drug metabolizing enzymes. |
| doi_str_mv | 10.3109/08923978509047631 |
| format | Article |
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Miconazole was found to exert a biphasic influence on both cellular immune response and hepatic drug metabolism in adult Swiss mice. Indeed, at the dose of 2.5 or 12.5 ma/kg/twice daily via intraperitoneal route, miconazole depressed delayed-type hypersensitivity (DTH) to sheep red blood cells and hepatic drug metabolism as determined from barbiturate sleeping time, following one-day treatment. By contrast, at the same dose level, miconazole enhanced DTH and hepatic drug metabolism after a five-day administration schedule. Primary humoral response and colloidal carbon clearance were not affected. Although the underlying mechanism remains to be fully elucidated, these findings clearly suggest a close relation between modulation of the cellular immune response and activity of liver drug metabolizing enzymes.</description><identifier>ISSN: 0892-3973</identifier><identifier>ISSN: 0163-0571</identifier><identifier>EISSN: 1532-2513</identifier><identifier>DOI: 10.3109/08923978509047631</identifier><identifier>PMID: 4031508</identifier><language>eng</language><publisher>New York, NY: Informa UK Ltd</publisher><subject>Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antibody Formation - drug effects ; Antifungal agents ; Biological and medical sciences ; Female ; Immunity, Cellular - drug effects ; Liver - drug effects ; Liver - metabolism ; Male ; Medical sciences ; Mice ; Miconazole - pharmacology ; Mononuclear Phagocyte System - drug effects ; Pentobarbital - pharmacology ; Pharmacology. Drug treatments ; Sleep - drug effects</subject><ispartof>Immunopharmacology and immunotoxicology, 1985, Vol.7 (2), p.171-178</ispartof><rights>1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-7d8ed644fbf3c55d4ec65c6ee38caeb209472d440a61b616051a4dd04e7105b3</citedby><cites>FETCH-LOGICAL-c495t-7d8ed644fbf3c55d4ec65c6ee38caeb209472d440a61b616051a4dd04e7105b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08923978509047631$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08923978509047631$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9216130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4031508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Descotes, J.</creatorcontrib><creatorcontrib>AndrÉ, P.</creatorcontrib><creatorcontrib>Tedone, R.</creatorcontrib><creatorcontrib>Evreux, J. Cl</creatorcontrib><title>Miconazole Influence on Both Cellular Immune Response and Hepatic Drug Metabolism in Mice</title><title>Immunopharmacology and immunotoxicology</title><addtitle>J Immunopharmacol</addtitle><description>Abstract
Miconazole was found to exert a biphasic influence on both cellular immune response and hepatic drug metabolism in adult Swiss mice. Indeed, at the dose of 2.5 or 12.5 ma/kg/twice daily via intraperitoneal route, miconazole depressed delayed-type hypersensitivity (DTH) to sheep red blood cells and hepatic drug metabolism as determined from barbiturate sleeping time, following one-day treatment. By contrast, at the same dose level, miconazole enhanced DTH and hepatic drug metabolism after a five-day administration schedule. Primary humoral response and colloidal carbon clearance were not affected. Although the underlying mechanism remains to be fully elucidated, these findings clearly suggest a close relation between modulation of the cellular immune response and activity of liver drug metabolizing enzymes.</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antibody Formation - drug effects</subject><subject>Antifungal agents</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Immunity, Cellular - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Miconazole - pharmacology</subject><subject>Mononuclear Phagocyte System - drug effects</subject><subject>Pentobarbital - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Sleep - drug effects</subject><issn>0892-3973</issn><issn>0163-0571</issn><issn>1532-2513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS1EVZbCH8AByQfELdSOv2LBpSwfXakVEuqFUzSxJ2wqx17sRKj89aTapRKq1J7m8H7vaeYNIa84eyc4s6essbWwplHMMmm04E_IiitRV7Xi4ilZ3erVAohn5Hkp14xxa5g6JseSCa5YsyI_LgeXIvxJAekm9mHG6JCmSD-maUvXGMIcINPNOM4R6XcsuxQLUoienuMOpsHRT3n-SS9xgi6FoYx0iHQJxRfkqIdQ8OVhnpCrL5-v1ufVxbevm_XZReWkVVNlfINeS9l3vXBKeYlOK6cRReMAu5pZaWovJQPNO801Uxyk90yi4Ux14oS83cfucvo1Y5nacShu2Rsiprm0RtfGCGkeBblUjaitWkC-B11OpWTs210eRsg3LWftbe3tvdoXz-tD-NyN6O8ch54X_c1Bh-Ig9BmiG8odZmuuuWAL9mGPDbFPeYTfKQffTnATUv7nEQ9t8f4_-xYhTFsHGdvrNOe4vOGBG_4CsyKuhA</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>Descotes, J.</creator><creator>AndrÉ, P.</creator><creator>Tedone, R.</creator><creator>Evreux, J. 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Antiparasitic agents</topic><topic>Antibody Formation - drug effects</topic><topic>Antifungal agents</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Immunity, Cellular - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Miconazole - pharmacology</topic><topic>Mononuclear Phagocyte System - drug effects</topic><topic>Pentobarbital - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Sleep - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Descotes, J.</creatorcontrib><creatorcontrib>AndrÉ, P.</creatorcontrib><creatorcontrib>Tedone, R.</creatorcontrib><creatorcontrib>Evreux, J. 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Cl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Miconazole Influence on Both Cellular Immune Response and Hepatic Drug Metabolism in Mice</atitle><jtitle>Immunopharmacology and immunotoxicology</jtitle><addtitle>J Immunopharmacol</addtitle><date>1985</date><risdate>1985</risdate><volume>7</volume><issue>2</issue><spage>171</spage><epage>178</epage><pages>171-178</pages><issn>0892-3973</issn><issn>0163-0571</issn><eissn>1532-2513</eissn><abstract>Abstract
Miconazole was found to exert a biphasic influence on both cellular immune response and hepatic drug metabolism in adult Swiss mice. Indeed, at the dose of 2.5 or 12.5 ma/kg/twice daily via intraperitoneal route, miconazole depressed delayed-type hypersensitivity (DTH) to sheep red blood cells and hepatic drug metabolism as determined from barbiturate sleeping time, following one-day treatment. By contrast, at the same dose level, miconazole enhanced DTH and hepatic drug metabolism after a five-day administration schedule. Primary humoral response and colloidal carbon clearance were not affected. Although the underlying mechanism remains to be fully elucidated, these findings clearly suggest a close relation between modulation of the cellular immune response and activity of liver drug metabolizing enzymes.</abstract><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>4031508</pmid><doi>10.3109/08923978509047631</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0892-3973 |
| ispartof | Immunopharmacology and immunotoxicology, 1985, Vol.7 (2), p.171-178 |
| issn | 0892-3973 0163-0571 1532-2513 |
| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antibody Formation - drug effects Antifungal agents Biological and medical sciences Female Immunity, Cellular - drug effects Liver - drug effects Liver - metabolism Male Medical sciences Mice Miconazole - pharmacology Mononuclear Phagocyte System - drug effects Pentobarbital - pharmacology Pharmacology. Drug treatments Sleep - drug effects |
| title | Miconazole Influence on Both Cellular Immune Response and Hepatic Drug Metabolism in Mice |
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