Pemphigus Antibodies and Shedding Snake Serum Enhance Susceptibility of Epidermal Keratinocytes in Natural Cytotoxic Reactions

In order to clarify the role of natural cytotoxicity (NC) in the damage of epidermal keratinocytes (EK) in pemphigus vulgaris (PV) we used the direct 51Cr-release assay in studying the cytotoxic activity of large grandular lymphocytes (LGL), obtained from 34 acute PV patients and 19 healthy donors a...

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Veröffentlicht in:	Autoimmunity (Chur, Switzerland) Switzerland), 1990, Vol.8 (1), p.9-16
Hauptverfasser:	Grando, Sergei A., Vasllyev, Alexander N., Kostromin, Alexander P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Antigens - immunology Autoimmunity - immunology Biological Evolution Blood Proteins - immunology Blood Proteins - pharmacology Cell Membrane - immunology Cytotoxicity, Immunologic epidermal keratinocytes Humans Immunoglobulin G - immunology Keratinocytes - drug effects Keratinocytes - immunology Lymphocytes - enzymology Lymphocytes - immunology Mice Mice, Inbred BALB C Natural cytotoxicity Pemphigus - immunology pemphigus vulgaris antibodies pemphigus vulgaris antigen Serine Endopeptidases - analysis shedding snake serum protein Skin - drug effects Skin - immunology Snakes
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