Elevated Tumor Necrosis Factor-α in Association with Severe Anemia in Human Immunodeficiency Virus Infection and Mycobacterium Avium Intracellulare Infection
Mycobacterium avium intracellulare (MAI) infection is a serious opportunistic infection that occurs in children with human immunodeficiency virus (HIV) infection. In MAI the hematologic system is profoundly affected. In the present study the hematologic manifestations of MAI in 37 HIV-infected infan...
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| Veröffentlicht in: | Pediatric hematology and oncology 1995, Vol.12 (3), p.221-230 |
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| creator | Ellaurie, Maadhava Rubinstein, Arye |
| description | Mycobacterium avium intracellulare (MAI) infection is a serious opportunistic infection that occurs in children with human immunodeficiency virus (HIV) infection. In MAI the hematologic system is profoundly affected. In the present study the hematologic manifestations of MAI in 37 HIV-infected infants and children were reviewed. Anemia was the predominant feature in all patients, with severe anemia (hemoglobin < 6 g/dL) occurring in 7 of 34 (21%) patients. This was followed by leukopenia (79%), monocytosis (82%), thrombocytopenia (59%), leukoerythroblastic reaction (68%), and neutropenia (41%). Serum tumor necrosis factor (TNF)-α was markedly elevated in all patients with MAI with an X ± SE of 702 ± 182 pg/mL. There was an association between elevated TNF-α and anemia in these patients. |
| doi_str_mv | 10.3109/08880019509029563 |
| format | Article |
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In MAI the hematologic system is profoundly affected. In the present study the hematologic manifestations of MAI in 37 HIV-infected infants and children were reviewed. Anemia was the predominant feature in all patients, with severe anemia (hemoglobin < 6 g/dL) occurring in 7 of 34 (21%) patients. This was followed by leukopenia (79%), monocytosis (82%), thrombocytopenia (59%), leukoerythroblastic reaction (68%), and neutropenia (41%). Serum tumor necrosis factor (TNF)-α was markedly elevated in all patients with MAI with an X ± SE of 702 ± 182 pg/mL. There was an association between elevated TNF-α and anemia in these patients.</description><identifier>ISSN: 0888-0018</identifier><identifier>EISSN: 1521-0669</identifier><identifier>DOI: 10.3109/08880019509029563</identifier><identifier>PMID: 7640175</identifier><identifier>CODEN: PHONEN</identifier><language>eng</language><publisher>Philadelphia, PA: Informa UK Ltd</publisher><subject>Adolescent ; AIDS ; AIDS-Related Opportunistic Infections - blood ; AIDS-Related Opportunistic Infections - immunology ; AIDS/HIV ; anemia ; Anemia - blood ; Anemia - immunology ; Biological and medical sciences ; CD4 Lymphocyte Count ; Child ; Child, Preschool ; Female ; HIV ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infant ; Male ; Medical sciences ; Mycobacterium avium intracellulare (MAI) ; Mycobacterium avium-intracellulare Infection - blood ; Mycobacterium avium-intracellulare Infection - immunology ; tumor necrosis factor (TNF) ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>Pediatric hematology and oncology, 1995, Vol.12 (3), p.221-230</ispartof><rights>1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-8ec37b4725941218bfab010d565a0c55deca9b01841ab66da5e56bca28cbe9da3</citedby><cites>FETCH-LOGICAL-c459t-8ec37b4725941218bfab010d565a0c55deca9b01841ab66da5e56bca28cbe9da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08880019509029563$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08880019509029563$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4009,27902,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3562418$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7640175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellaurie, Maadhava</creatorcontrib><creatorcontrib>Rubinstein, Arye</creatorcontrib><title>Elevated Tumor Necrosis Factor-α in Association with Severe Anemia in Human Immunodeficiency Virus Infection and Mycobacterium Avium Intracellulare Infection</title><title>Pediatric hematology and oncology</title><addtitle>Pediatr Hematol Oncol</addtitle><description>Mycobacterium avium intracellulare (MAI) infection is a serious opportunistic infection that occurs in children with human immunodeficiency virus (HIV) infection. In MAI the hematologic system is profoundly affected. In the present study the hematologic manifestations of MAI in 37 HIV-infected infants and children were reviewed. Anemia was the predominant feature in all patients, with severe anemia (hemoglobin < 6 g/dL) occurring in 7 of 34 (21%) patients. This was followed by leukopenia (79%), monocytosis (82%), thrombocytopenia (59%), leukoerythroblastic reaction (68%), and neutropenia (41%). Serum tumor necrosis factor (TNF)-α was markedly elevated in all patients with MAI with an X ± SE of 702 ± 182 pg/mL. There was an association between elevated TNF-α and anemia in these patients.</description><subject>Adolescent</subject><subject>AIDS</subject><subject>AIDS-Related Opportunistic Infections - blood</subject><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>AIDS/HIV</subject><subject>anemia</subject><subject>Anemia - blood</subject><subject>Anemia - immunology</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>HIV</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycobacterium avium intracellulare (MAI)</subject><subject>Mycobacterium avium-intracellulare Infection - blood</subject><subject>Mycobacterium avium-intracellulare Infection - immunology</subject><subject>tumor necrosis factor (TNF)</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0888-0018</issn><issn>1521-0669</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURS1EVYbCB7BA8gJ1F7CTOHEEm1HV0pHasqCwjV6cF42r2C52PNX8DP_Aj_BNOMwwEqrUjS35nnv1_C4hbzh7X3DWfGBSSsZ4I1jD8kZUxTOy4CLnGauq5jlZzHqWAPmCvAzhjjGWF3V-TI7rqmS8Fgvy83zEDUzY09tonKc3qLwLOtALUJPz2e9fVFu6DMEpDZN2lj7oaU2_4gY90qVFo2EmLqMBS1fGROt6HLTSaNWWftc-BrqyA6q_ZrA9vd4q16V09DoautzM58pOHhSOYxwh5R4Mr8jRAGPA1_v7hHy7OL89u8yuvnxenS2vMlWKZsokqqLuyjoXTclzLrsBOsZZLyoBTAnRo4ImvciSQ1dVPQgUVacgl6rDpofihJzucu-9-xExTK3RYZ4HLLoY2rouBS_LIoF8B85rCh6H9t5rA37bctbOnbSPOkmet_vw2BnsD459CUl_t9chKBgHD1bpcMAKUeUllwn7tMO0HZw38OD82LcTbEfn_3mKp6b4-J99jTBOa5XW3d656G1a7xN_-AMxYr03</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Ellaurie, Maadhava</creator><creator>Rubinstein, Arye</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Elevated Tumor Necrosis Factor-α in Association with Severe Anemia in Human Immunodeficiency Virus Infection and Mycobacterium Avium Intracellulare Infection</title><author>Ellaurie, Maadhava ; Rubinstein, Arye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-8ec37b4725941218bfab010d565a0c55deca9b01841ab66da5e56bca28cbe9da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>AIDS</topic><topic>AIDS-Related Opportunistic Infections - blood</topic><topic>AIDS-Related Opportunistic Infections - immunology</topic><topic>AIDS/HIV</topic><topic>anemia</topic><topic>Anemia - blood</topic><topic>Anemia - immunology</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>HIV</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mycobacterium avium intracellulare (MAI)</topic><topic>Mycobacterium avium-intracellulare Infection - blood</topic><topic>Mycobacterium avium-intracellulare Infection - immunology</topic><topic>tumor necrosis factor (TNF)</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ellaurie, Maadhava</creatorcontrib><creatorcontrib>Rubinstein, Arye</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric hematology and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellaurie, Maadhava</au><au>Rubinstein, Arye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Tumor Necrosis Factor-α in Association with Severe Anemia in Human Immunodeficiency Virus Infection and Mycobacterium Avium Intracellulare Infection</atitle><jtitle>Pediatric hematology and oncology</jtitle><addtitle>Pediatr Hematol Oncol</addtitle><date>1995</date><risdate>1995</risdate><volume>12</volume><issue>3</issue><spage>221</spage><epage>230</epage><pages>221-230</pages><issn>0888-0018</issn><eissn>1521-0669</eissn><coden>PHONEN</coden><abstract>Mycobacterium avium intracellulare (MAI) infection is a serious opportunistic infection that occurs in children with human immunodeficiency virus (HIV) infection. In MAI the hematologic system is profoundly affected. In the present study the hematologic manifestations of MAI in 37 HIV-infected infants and children were reviewed. Anemia was the predominant feature in all patients, with severe anemia (hemoglobin < 6 g/dL) occurring in 7 of 34 (21%) patients. This was followed by leukopenia (79%), monocytosis (82%), thrombocytopenia (59%), leukoerythroblastic reaction (68%), and neutropenia (41%). Serum tumor necrosis factor (TNF)-α was markedly elevated in all patients with MAI with an X ± SE of 702 ± 182 pg/mL. There was an association between elevated TNF-α and anemia in these patients.</abstract><cop>Philadelphia, PA</cop><pub>Informa UK Ltd</pub><pmid>7640175</pmid><doi>10.3109/08880019509029563</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Pediatric hematology and oncology, 1995, Vol.12 (3), p.221-230 |
| issn | 0888-0018 1521-0669 |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_08880019509029563 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adolescent AIDS AIDS-Related Opportunistic Infections - blood AIDS-Related Opportunistic Infections - immunology AIDS/HIV anemia Anemia - blood Anemia - immunology Biological and medical sciences CD4 Lymphocyte Count Child Child, Preschool Female HIV Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infant Male Medical sciences Mycobacterium avium intracellulare (MAI) Mycobacterium avium-intracellulare Infection - blood Mycobacterium avium-intracellulare Infection - immunology tumor necrosis factor (TNF) Tumor Necrosis Factor-alpha - analysis |
| title | Elevated Tumor Necrosis Factor-α in Association with Severe Anemia in Human Immunodeficiency Virus Infection and Mycobacterium Avium Intracellulare Infection |
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