Abnormal Serum Phenylalanine-Tyrosine Ratio and Hyperferritinemia in Malignant Histiocytosis
Nine cases of childhood malignant histiocytosis (MH) showed an abnormally high serum phenylalanine (Phe)/tyrosine (Tyr) ratio (3.47±1.32) coincident with hyperferritinemia (50,800 ± 33,600 ng/ml). Lactate dehydrogenase activity was also increased in these patients. These values were compared with da...
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| Veröffentlicht in: | Pediatric hematology and oncology 1988, Vol.5 (4), p.299-307 |
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| container_title | Pediatric hematology and oncology |
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| creator | Imashuku, Shinsaku Morioka, Yoshihito Kodo, Naoki Esumi, Noriko Hibi, Shigeyoshi Todo, Shinjiro |
| description | Nine cases of childhood malignant histiocytosis (MH) showed an abnormally high serum phenylalanine (Phe)/tyrosine (Tyr) ratio (3.47±1.32) coincident with hyperferritinemia (50,800 ± 33,600 ng/ml). Lactate dehydrogenase activity was also increased in these patients. These values were compared with data on sera from two groups of patients, acute leukemia cases (n=14) and measles cases (n=13), and with control values from normal healthy children (n=38). The Phe/Tyr ratio was 1.57±0.54 for the acute leukemia (p > 0.01) and 2.58 ±1.46 for the measles cases (NS), serum ferritin was 245 ± 124 ng/ml for acute leukemia (p > 0.01) and 167 ±117 ng/ml for measles (p > 0.01). Accordingly, the concurrence of both abnormalities is considered to be characteristic for MH. It was also found that both serum Phe/Tyr ratio and ferritin levels reflect the disease activity, indicating that these two factors are useful prognostic indicators in the treatment of patients with MH. |
| doi_str_mv | 10.3109/08880018809037370 |
| format | Article |
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Lactate dehydrogenase activity was also increased in these patients. These values were compared with data on sera from two groups of patients, acute leukemia cases (n=14) and measles cases (n=13), and with control values from normal healthy children (n=38). The Phe/Tyr ratio was 1.57±0.54 for the acute leukemia (p > 0.01) and 2.58 ±1.46 for the measles cases (NS), serum ferritin was 245 ± 124 ng/ml for acute leukemia (p > 0.01) and 167 ±117 ng/ml for measles (p > 0.01). Accordingly, the concurrence of both abnormalities is considered to be characteristic for MH. It was also found that both serum Phe/Tyr ratio and ferritin levels reflect the disease activity, indicating that these two factors are useful prognostic indicators in the treatment of patients with MH.</description><identifier>ISSN: 0888-0018</identifier><identifier>EISSN: 1521-0669</identifier><identifier>DOI: 10.3109/08880018809037370</identifier><identifier>PMID: 3152976</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adolescent ; Child ; Child, Preschool ; Female ; Ferritins - blood ; Histiocytic Sarcoma - blood ; Humans ; hyperferritinemia ; Infant ; L-Lactate Dehydrogenase - blood ; Leukemia, Myeloid, Acute - blood ; Male ; malignant histiocytosis ; Measles - blood ; phenylalanine ; Phenylalanine - blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood ; Pteridines - urine ; tyrosine ; Tyrosine - blood</subject><ispartof>Pediatric hematology and oncology, 1988, Vol.5 (4), p.299-307</ispartof><rights>1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-38831f334cd87f5797a383de309045e07e9f98b3e2dd6a99f7f8f74586b21873</citedby><cites>FETCH-LOGICAL-c401t-38831f334cd87f5797a383de309045e07e9f98b3e2dd6a99f7f8f74586b21873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08880018809037370$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08880018809037370$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3152976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imashuku, Shinsaku</creatorcontrib><creatorcontrib>Morioka, Yoshihito</creatorcontrib><creatorcontrib>Kodo, Naoki</creatorcontrib><creatorcontrib>Esumi, Noriko</creatorcontrib><creatorcontrib>Hibi, Shigeyoshi</creatorcontrib><creatorcontrib>Todo, Shinjiro</creatorcontrib><title>Abnormal Serum Phenylalanine-Tyrosine Ratio and Hyperferritinemia in Malignant Histiocytosis</title><title>Pediatric hematology and oncology</title><addtitle>Pediatr Hematol Oncol</addtitle><description>Nine cases of childhood malignant histiocytosis (MH) showed an abnormally high serum phenylalanine (Phe)/tyrosine (Tyr) ratio (3.47±1.32) coincident with hyperferritinemia (50,800 ± 33,600 ng/ml). Lactate dehydrogenase activity was also increased in these patients. These values were compared with data on sera from two groups of patients, acute leukemia cases (n=14) and measles cases (n=13), and with control values from normal healthy children (n=38). The Phe/Tyr ratio was 1.57±0.54 for the acute leukemia (p > 0.01) and 2.58 ±1.46 for the measles cases (NS), serum ferritin was 245 ± 124 ng/ml for acute leukemia (p > 0.01) and 167 ±117 ng/ml for measles (p > 0.01). Accordingly, the concurrence of both abnormalities is considered to be characteristic for MH. It was also found that both serum Phe/Tyr ratio and ferritin levels reflect the disease activity, indicating that these two factors are useful prognostic indicators in the treatment of patients with MH.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Ferritins - blood</subject><subject>Histiocytic Sarcoma - blood</subject><subject>Humans</subject><subject>hyperferritinemia</subject><subject>Infant</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Leukemia, Myeloid, Acute - blood</subject><subject>Male</subject><subject>malignant histiocytosis</subject><subject>Measles - blood</subject><subject>phenylalanine</subject><subject>Phenylalanine - blood</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood</subject><subject>Pteridines - urine</subject><subject>tyrosine</subject><subject>Tyrosine - blood</subject><issn>0888-0018</issn><issn>1521-0669</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LwzAcxoMoc04_gAehJ2_VpOmaBL2MoU5QFN1RKGn7j8tI05m0SL-9KRuCiF6SwPNCnh9CpwRfUILFJeacY0zCITBllOE9NCbThMQ4y8Q-Gg96PBgO0ZH3a4xxQlkyQiMaXIJlY_Q2K2zjammiV3BdHT2vwPZGGmm1hXjZu8aHR_QiW91E0lbRot-AU-CcboNQaxlpGz1Ko9-ttG200D44y74NOX-MDpQ0Hk529wQtb2-W80X88HR3P589xGWKSRtTzilRlKZlxZmaMsEk5bQCGlalU8AMhBK8oJBUVSaFUExxxdIpz4qEcEYn6Hxbu3HNRwe-zWvtSzBhBDSdz1ngQ9IsDUayNZZhlneg8o3TtXR9TnA-AM1_AQ2Zs115V9RQfSd2BIN-vdW1VQPIz8aZKm9lbxqnnLSl9kP13_VXP-IrkKZdldJBvm46ZwO2fz73BTsvloA</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Imashuku, Shinsaku</creator><creator>Morioka, Yoshihito</creator><creator>Kodo, Naoki</creator><creator>Esumi, Noriko</creator><creator>Hibi, Shigeyoshi</creator><creator>Todo, Shinjiro</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Abnormal Serum Phenylalanine-Tyrosine Ratio and Hyperferritinemia in Malignant Histiocytosis</title><author>Imashuku, Shinsaku ; Morioka, Yoshihito ; Kodo, Naoki ; Esumi, Noriko ; Hibi, Shigeyoshi ; Todo, Shinjiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-38831f334cd87f5797a383de309045e07e9f98b3e2dd6a99f7f8f74586b21873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Ferritins - blood</topic><topic>Histiocytic Sarcoma - blood</topic><topic>Humans</topic><topic>hyperferritinemia</topic><topic>Infant</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Leukemia, Myeloid, Acute - blood</topic><topic>Male</topic><topic>malignant histiocytosis</topic><topic>Measles - blood</topic><topic>phenylalanine</topic><topic>Phenylalanine - blood</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood</topic><topic>Pteridines - urine</topic><topic>tyrosine</topic><topic>Tyrosine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imashuku, Shinsaku</creatorcontrib><creatorcontrib>Morioka, Yoshihito</creatorcontrib><creatorcontrib>Kodo, Naoki</creatorcontrib><creatorcontrib>Esumi, Noriko</creatorcontrib><creatorcontrib>Hibi, Shigeyoshi</creatorcontrib><creatorcontrib>Todo, Shinjiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric hematology and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imashuku, Shinsaku</au><au>Morioka, Yoshihito</au><au>Kodo, Naoki</au><au>Esumi, Noriko</au><au>Hibi, Shigeyoshi</au><au>Todo, Shinjiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal Serum Phenylalanine-Tyrosine Ratio and Hyperferritinemia in Malignant Histiocytosis</atitle><jtitle>Pediatric hematology and oncology</jtitle><addtitle>Pediatr Hematol Oncol</addtitle><date>1988</date><risdate>1988</risdate><volume>5</volume><issue>4</issue><spage>299</spage><epage>307</epage><pages>299-307</pages><issn>0888-0018</issn><eissn>1521-0669</eissn><abstract>Nine cases of childhood malignant histiocytosis (MH) showed an abnormally high serum phenylalanine (Phe)/tyrosine (Tyr) ratio (3.47±1.32) coincident with hyperferritinemia (50,800 ± 33,600 ng/ml). Lactate dehydrogenase activity was also increased in these patients. These values were compared with data on sera from two groups of patients, acute leukemia cases (n=14) and measles cases (n=13), and with control values from normal healthy children (n=38). The Phe/Tyr ratio was 1.57±0.54 for the acute leukemia (p > 0.01) and 2.58 ±1.46 for the measles cases (NS), serum ferritin was 245 ± 124 ng/ml for acute leukemia (p > 0.01) and 167 ±117 ng/ml for measles (p > 0.01). Accordingly, the concurrence of both abnormalities is considered to be characteristic for MH. It was also found that both serum Phe/Tyr ratio and ferritin levels reflect the disease activity, indicating that these two factors are useful prognostic indicators in the treatment of patients with MH.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>3152976</pmid><doi>10.3109/08880018809037370</doi><tpages>9</tpages></addata></record> |
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| source | Taylor & Francis CRKN Medical; Taylor & Francis; MEDLINE |
| subjects | Adolescent Child Child, Preschool Female Ferritins - blood Histiocytic Sarcoma - blood Humans hyperferritinemia Infant L-Lactate Dehydrogenase - blood Leukemia, Myeloid, Acute - blood Male malignant histiocytosis Measles - blood phenylalanine Phenylalanine - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Pteridines - urine tyrosine Tyrosine - blood |
| title | Abnormal Serum Phenylalanine-Tyrosine Ratio and Hyperferritinemia in Malignant Histiocytosis |
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