Hyperuricemia and chronic kidney disease: an enigma yet to be solved
Abstract The role of uric acid (UA) on the pathogenesis and progression of chronic kidney disease (CKD) remains controversial. Experimental and clinical studies indicate that UA is associated with several risk factors of CKD including diabetes, hypertension, oxidative stress, and inflammation and hy...
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| Veröffentlicht in: | Renal failure 2014-10, Vol.36 (9), p.1351-1359 |
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| container_title | Renal failure |
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| creator | Dousdampanis, Periklis Trigka, Konstantina Musso, Carlos G. Fourtounas, Costas |
| description | Abstract
The role of uric acid (UA) on the pathogenesis and progression of chronic kidney disease (CKD) remains controversial. Experimental and clinical studies indicate that UA is associated with several risk factors of CKD including diabetes, hypertension, oxidative stress, and inflammation and hyperuricemia could be considered as a common dominator linking CKD and cardiovascular disease. Notably, the impact of serum UA levels on the survival of CKD, dialysis patients, and renal transplant recipients is also a matter of debate, as there are conflicting results from clinical studies. At present, there is no definite data whether UA is causal, compensatory, coincidental or it is only an epiphenomenon in these patients. In this article, we attempt to review and elucidate the dark side of this old molecule in CKD and renal transplantation. |
| doi_str_mv | 10.3109/0886022X.2014.947516 |
| format | Article |
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The role of uric acid (UA) on the pathogenesis and progression of chronic kidney disease (CKD) remains controversial. Experimental and clinical studies indicate that UA is associated with several risk factors of CKD including diabetes, hypertension, oxidative stress, and inflammation and hyperuricemia could be considered as a common dominator linking CKD and cardiovascular disease. Notably, the impact of serum UA levels on the survival of CKD, dialysis patients, and renal transplant recipients is also a matter of debate, as there are conflicting results from clinical studies. At present, there is no definite data whether UA is causal, compensatory, coincidental or it is only an epiphenomenon in these patients. In this article, we attempt to review and elucidate the dark side of this old molecule in CKD and renal transplantation.</description><identifier>ISSN: 0886-022X</identifier><identifier>EISSN: 1525-6049</identifier><identifier>DOI: 10.3109/0886022X.2014.947516</identifier><identifier>PMID: 25112538</identifier><language>eng</language><publisher>England: Informa Healthcare USA, Inc</publisher><subject>Chronic kidney disease ; dialysis ; Humans ; hyperuricemia ; Hyperuricemia - blood ; Hyperuricemia - complications ; Kidney - physiopathology ; Kidney Transplantation ; mortality ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - complications ; renal transplantation ; Risk Factors ; Uric Acid - blood</subject><ispartof>Renal failure, 2014-10, Vol.36 (9), p.1351-1359</ispartof><rights>2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-a54870eb11f59d8b662f951a558dda78ab186732a03014f1e74ed4b5631f5fe53</citedby><cites>FETCH-LOGICAL-c418t-a54870eb11f59d8b662f951a558dda78ab186732a03014f1e74ed4b5631f5fe53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25112538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dousdampanis, Periklis</creatorcontrib><creatorcontrib>Trigka, Konstantina</creatorcontrib><creatorcontrib>Musso, Carlos G.</creatorcontrib><creatorcontrib>Fourtounas, Costas</creatorcontrib><title>Hyperuricemia and chronic kidney disease: an enigma yet to be solved</title><title>Renal failure</title><addtitle>Ren Fail</addtitle><description>Abstract
The role of uric acid (UA) on the pathogenesis and progression of chronic kidney disease (CKD) remains controversial. Experimental and clinical studies indicate that UA is associated with several risk factors of CKD including diabetes, hypertension, oxidative stress, and inflammation and hyperuricemia could be considered as a common dominator linking CKD and cardiovascular disease. Notably, the impact of serum UA levels on the survival of CKD, dialysis patients, and renal transplant recipients is also a matter of debate, as there are conflicting results from clinical studies. At present, there is no definite data whether UA is causal, compensatory, coincidental or it is only an epiphenomenon in these patients. In this article, we attempt to review and elucidate the dark side of this old molecule in CKD and renal transplantation.</description><subject>Chronic kidney disease</subject><subject>dialysis</subject><subject>Humans</subject><subject>hyperuricemia</subject><subject>Hyperuricemia - blood</subject><subject>Hyperuricemia - complications</subject><subject>Kidney - physiopathology</subject><subject>Kidney Transplantation</subject><subject>mortality</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>renal transplantation</subject><subject>Risk Factors</subject><subject>Uric Acid - blood</subject><issn>0886-022X</issn><issn>1525-6049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EotvCGyDkI5csHsd2HA4gVApFqsQFJG7WJJ6wLkm82Akob0-ibZG49DQHf_8_44-xFyD2JYj6tbDWCCm_76UAta9VpcE8YjvQUhdGqPox221IsTFn7DznWyFA20o-ZWdSA0hd2h37cL0cKc0ptDQE5Dh63h5SHEPLfwY_0sJ9yISZ3qxvnMbwY0C-0MSnyBviOfa_yT9jTzrsMz2_mxfs28err5fXxc2XT58v398UrQI7FaiVrQQ1AJ2uvW2MkV2tAbW23mNlsQFrqlKiKNcvdUCVIq8abco10JEuL9irU-8xxV8z5ckNIbfU9zhSnLMDbZQRGkpYUXVC2xRzTtS5YwoDpsWBcJs_d-_Pbf7cyd8ae3m3YW4G8v9C98JW4N0JCGMX04B_Yuq9m3DpY-oSjm3IW_2DK97-13Ag7KdDi4ncbZzTuAp8-Ma_inuRqw</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Dousdampanis, Periklis</creator><creator>Trigka, Konstantina</creator><creator>Musso, Carlos G.</creator><creator>Fourtounas, Costas</creator><general>Informa Healthcare USA, Inc</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Hyperuricemia and chronic kidney disease: an enigma yet to be solved</title><author>Dousdampanis, Periklis ; Trigka, Konstantina ; Musso, Carlos G. ; Fourtounas, Costas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-a54870eb11f59d8b662f951a558dda78ab186732a03014f1e74ed4b5631f5fe53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Chronic kidney disease</topic><topic>dialysis</topic><topic>Humans</topic><topic>hyperuricemia</topic><topic>Hyperuricemia - blood</topic><topic>Hyperuricemia - complications</topic><topic>Kidney - physiopathology</topic><topic>Kidney Transplantation</topic><topic>mortality</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>renal transplantation</topic><topic>Risk Factors</topic><topic>Uric Acid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dousdampanis, Periklis</creatorcontrib><creatorcontrib>Trigka, Konstantina</creatorcontrib><creatorcontrib>Musso, Carlos G.</creatorcontrib><creatorcontrib>Fourtounas, Costas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Renal failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dousdampanis, Periklis</au><au>Trigka, Konstantina</au><au>Musso, Carlos G.</au><au>Fourtounas, Costas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperuricemia and chronic kidney disease: an enigma yet to be solved</atitle><jtitle>Renal failure</jtitle><addtitle>Ren Fail</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>36</volume><issue>9</issue><spage>1351</spage><epage>1359</epage><pages>1351-1359</pages><issn>0886-022X</issn><eissn>1525-6049</eissn><abstract>Abstract
The role of uric acid (UA) on the pathogenesis and progression of chronic kidney disease (CKD) remains controversial. Experimental and clinical studies indicate that UA is associated with several risk factors of CKD including diabetes, hypertension, oxidative stress, and inflammation and hyperuricemia could be considered as a common dominator linking CKD and cardiovascular disease. Notably, the impact of serum UA levels on the survival of CKD, dialysis patients, and renal transplant recipients is also a matter of debate, as there are conflicting results from clinical studies. At present, there is no definite data whether UA is causal, compensatory, coincidental or it is only an epiphenomenon in these patients. In this article, we attempt to review and elucidate the dark side of this old molecule in CKD and renal transplantation.</abstract><cop>England</cop><pub>Informa Healthcare USA, Inc</pub><pmid>25112538</pmid><doi>10.3109/0886022X.2014.947516</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Chronic kidney disease dialysis Humans hyperuricemia Hyperuricemia - blood Hyperuricemia - complications Kidney - physiopathology Kidney Transplantation mortality Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications renal transplantation Risk Factors Uric Acid - blood |
| title | Hyperuricemia and chronic kidney disease: an enigma yet to be solved |
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