Reduction of Toxicity of a Vinca Alkaloid by an Anti-Vinca Alkaloid Antibody

Inadvertent oncolytic overdoses occur rarely, but can have serious consequences. We have investigated the possibility of using an antibody, 27.8.1A, reactive with vinca alkaloids, as a means of reducing the toxicity associated with overdose situations. In vitro cytotoxicity of a vinca derivative, 4-...

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Veröffentlicht in:	Cancer investigation 1995, Vol.13 (4), p.370-374
Hauptverfasser:	Gutowski, Magda C., Fix, Daniel V., Corvalan, Jose R., Johnson, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Antineoplastic Agents - immunology Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - toxicity Biological and medical sciences Body Weight - drug effects Cell Survival - drug effects Drug Interactions Drug toxicity and drugs side effects treatment Female Humans Inactivation, Metabolic Kinetics Medical sciences Mice Mice, Inbred Strains Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Tumor Cells, Cultured Vinblastine - analogs & derivatives Vinblastine - immunology Vinblastine - pharmacokinetics Vinblastine - toxicity
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