Identification of Factors Affecting Preservative Efficacy and Chemical Stability of Lamivudine Oral Solution Through Statistical Experimental Design

Abstract To identify factors affecting the chemical stability and preservative efficacy of lamivudine oral liquid formulations, an optimization study using a central composite design was performed. In this design, five factors, each at three levels, were investigated: pH (4.5, 5.5, and 73, sucrose (...

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Veröffentlicht in:	Drug development and industrial pharmacy 1995, Vol.21 (14), p.1671-1682
Hauptverfasser:	Nguyen, Ngoc-Anh T., Wells, Mickey L., Cooper, David C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
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