Formulation studies on ibuprofen sodium-cationic dextran conjugate: effect on tableting and dissolution characteristics of ibuprofen

The effect of electrostatic interaction between ibuprofen sodium (IbS) and cationic diethylaminoethyl dextran (Ddex), on the tableting properties and ibuprofen release from the conjugate tablet was investigated. Ibuprofen exhibits poor flow, compaction (tableting) and dissolution behavior due to its...

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Veröffentlicht in:	Drug development and industrial pharmacy 2016-01, Vol.42 (1), p.39-59
Hauptverfasser:	Abioye, Amos Olusegun, Kola-Mustapha, Adeola
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Calorimetry, Differential Scanning Cations DEAE-Dextran - chemistry Delayed-Action Preparations - chemistry Drug Carriers - chemistry Drug Compounding - methods Drug Liberation Granulation Hydrogen Bonding Ibuprofen - administration & dosage Ibuprofen - chemistry Ibuprofen - pharmacokinetics ibuprofen-Ddex conjugate inter-particulate bonding mechanism of compaction mechanism of release Particle Size Solubility Spectroscopy, Fourier Transform Infrared Static Electricity Tablets
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