Tablet formulation of an active pharmaceutical ingredient with a sticking and filming problem: direct compression and dry granulation evaluations

Abstract Objective: To develop a tablet formulation for an active pharmaceutical ingredient for which sticking and filming problems occurred during tablet punching. Methods: Direct compression and dry granulation tableting techniques were evaluated using factorial experimental design. The effects of...

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Veröffentlicht in:	Drug development and industrial pharmacy 2015-02, Vol.41 (2), p.333-341
Hauptverfasser:	Bejugam, Naveen K., Mutyam, Shravan K., Shankar, Gita N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellulose - chemistry Chemistry, Pharmaceutical - instrumentation Chemistry, Pharmaceutical - methods Compressive Strength Direct compression dry granulation Excipients - chemistry Hardness Humans roller compaction statistical design stickiness tablets Tablets - chemistry
Online-Zugang:	Volltext
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