Study of the properties of the new biodegradable polyurethane PU (TEG-HMDI) as matrix forming excipient for controlled drug delivery
The purpose of this work is to study the ability of a new biodegradable polyurethane PU(TEG-HMDI) obtained by reaction of triethylene glycol (TEG) with 1,6-hexamethylene diisocyanate (HMDI) to act as matrix forming polymer for controlled release tablets and to estimate its percolation threshold in a...
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| Veröffentlicht in: | Drug development and industrial pharmacy 2013-11, Vol.39 (11), p.1758-1764 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Campiñez, María Dolores Aguilar-de-Leyva, Ángela Ferris, Cristina de Paz, M. Violante Galbis, Juan Antonio Caraballo, Isidoro |
| description | The purpose of this work is to study the ability of a new biodegradable polyurethane PU(TEG-HMDI) obtained by reaction of triethylene glycol (TEG) with 1,6-hexamethylene diisocyanate (HMDI) to act as matrix forming polymer for controlled release tablets and to estimate its percolation threshold in a matrix system. Matrix tablets weighing 250 mg were prepared by direct compression with 10-30% wt/wt of PU(TEG-HMDI) and anhydrous theophylline as model drug. Release studies were carried out using the paddle method. The results were analyzed using the kinetics models of Higuchi, Korsmeyer-Peppas, and Peppas and Sahlin. These studies confirm the existence of an excipient percolation threshold between 10 and 20 % wt/wt of PU(TEG-HMDI) for the different batches prepared. It has been observed that the new biodegradable polyurethane PU(TEG-HMDI) shows adequate compatibility as well as a high ability to control the drug release. |
| doi_str_mv | 10.3109/03639045.2012.736516 |
| format | Article |
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Violante ; Galbis, Juan Antonio ; Caraballo, Isidoro</creator><creatorcontrib>Campiñez, María Dolores ; Aguilar-de-Leyva, Ángela ; Ferris, Cristina ; de Paz, M. Violante ; Galbis, Juan Antonio ; Caraballo, Isidoro</creatorcontrib><description>The purpose of this work is to study the ability of a new biodegradable polyurethane PU(TEG-HMDI) obtained by reaction of triethylene glycol (TEG) with 1,6-hexamethylene diisocyanate (HMDI) to act as matrix forming polymer for controlled release tablets and to estimate its percolation threshold in a matrix system. Matrix tablets weighing 250 mg were prepared by direct compression with 10-30% wt/wt of PU(TEG-HMDI) and anhydrous theophylline as model drug. Release studies were carried out using the paddle method. The results were analyzed using the kinetics models of Higuchi, Korsmeyer-Peppas, and Peppas and Sahlin. These studies confirm the existence of an excipient percolation threshold between 10 and 20 % wt/wt of PU(TEG-HMDI) for the different batches prepared. It has been observed that the new biodegradable polyurethane PU(TEG-HMDI) shows adequate compatibility as well as a high ability to control the drug release.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.3109/03639045.2012.736516</identifier><identifier>PMID: 24087856</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Biodegradable Plastics - chemical synthesis ; Biodegradable Plastics - chemistry ; biopolymer ; Chemical Phenomena ; Cyanates - chemistry ; Delayed-Action Preparations - chemistry ; Diffusion ; Drug Compounding ; Excipients - chemical synthesis ; Excipients - chemistry ; Hydrophilic matrix ; Hydrophobic and Hydrophilic Interactions ; Indicators and Reagents - chemistry ; Isocyanates ; Kinetics ; Mechanical Phenomena ; Models, Molecular ; Molecular Structure ; Molecular Weight ; percolation theory ; Polyethylene Glycols - chemistry ; Polyurethanes - chemical synthesis ; Polyurethanes - chemistry ; Solubility ; sustained release ; Tablets ; Theophylline - chemistry ; theophylline anhydrous ; Vasodilator Agents - chemistry ; Viscosity</subject><ispartof>Drug development and industrial pharmacy, 2013-11, Vol.39 (11), p.1758-1764</ispartof><rights>2013 Informa Healthcare USA, Inc. 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-365617a8d00a378ba40791b12fb8e8fda8f3d1b5373360b243447f66947b31113</citedby><cites>FETCH-LOGICAL-c418t-365617a8d00a378ba40791b12fb8e8fda8f3d1b5373360b243447f66947b31113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24087856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campiñez, María Dolores</creatorcontrib><creatorcontrib>Aguilar-de-Leyva, Ángela</creatorcontrib><creatorcontrib>Ferris, Cristina</creatorcontrib><creatorcontrib>de Paz, M. Violante</creatorcontrib><creatorcontrib>Galbis, Juan Antonio</creatorcontrib><creatorcontrib>Caraballo, Isidoro</creatorcontrib><title>Study of the properties of the new biodegradable polyurethane PU (TEG-HMDI) as matrix forming excipient for controlled drug delivery</title><title>Drug development and industrial pharmacy</title><addtitle>Drug Dev Ind Pharm</addtitle><description>The purpose of this work is to study the ability of a new biodegradable polyurethane PU(TEG-HMDI) obtained by reaction of triethylene glycol (TEG) with 1,6-hexamethylene diisocyanate (HMDI) to act as matrix forming polymer for controlled release tablets and to estimate its percolation threshold in a matrix system. Matrix tablets weighing 250 mg were prepared by direct compression with 10-30% wt/wt of PU(TEG-HMDI) and anhydrous theophylline as model drug. Release studies were carried out using the paddle method. The results were analyzed using the kinetics models of Higuchi, Korsmeyer-Peppas, and Peppas and Sahlin. These studies confirm the existence of an excipient percolation threshold between 10 and 20 % wt/wt of PU(TEG-HMDI) for the different batches prepared. It has been observed that the new biodegradable polyurethane PU(TEG-HMDI) shows adequate compatibility as well as a high ability to control the drug release.</description><subject>Biodegradable Plastics - chemical synthesis</subject><subject>Biodegradable Plastics - chemistry</subject><subject>biopolymer</subject><subject>Chemical Phenomena</subject><subject>Cyanates - chemistry</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Diffusion</subject><subject>Drug Compounding</subject><subject>Excipients - chemical synthesis</subject><subject>Excipients - chemistry</subject><subject>Hydrophilic matrix</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Indicators and Reagents - chemistry</subject><subject>Isocyanates</subject><subject>Kinetics</subject><subject>Mechanical Phenomena</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Molecular Weight</subject><subject>percolation theory</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyurethanes - chemical synthesis</subject><subject>Polyurethanes - chemistry</subject><subject>Solubility</subject><subject>sustained release</subject><subject>Tablets</subject><subject>Theophylline - chemistry</subject><subject>theophylline anhydrous</subject><subject>Vasodilator Agents - chemistry</subject><subject>Viscosity</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAURS0EotPCHyDkZVlksGPHSTYgVEpbqQgk2rVlxy8zrpx4sB3a7PvhOJoOEpuuLD2de5_fQegdJWtGSfuRMMFawqt1SWi5rpmoqHiBVrQqSVHVonyJVgtSLMwROo7xjmSwrarX6KjkpKmbSqzQ4680mRn7Hqct4F3wOwjJQjxMRrjH2noDm6CM0i4z3s1TgLRVI-Cft_j05vyiuPz-9eoDVhEPKgX7gHsfBjtuMDx0dmdhTMsEd35MwTsHBpswbbABZ_9AmN-gV71yEd4-vSfo9tv5zdllcf3j4ursy3XRcdqkIp8oaK0aQ4hidaMVJ3VLNS173UDTG9X0zFBdsZoxQXTJGed1L0TLa80opewEne57852_J4hJDjZ24Fw-xU9RUp4jRAhaZpTv0S74GAP0chfsoMIsKZGLf3nwLxf_cu8_x94_bZj0AOZf6CA8A5_3gB0XR-reB2dkUrPzoQ9q7Gxc6p9d8em_hi0ol7adCiDv_BTGLPD5P_4FOmOnng</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Campiñez, María Dolores</creator><creator>Aguilar-de-Leyva, Ángela</creator><creator>Ferris, Cristina</creator><creator>de Paz, M. Violante</creator><creator>Galbis, Juan Antonio</creator><creator>Caraballo, Isidoro</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>Study of the properties of the new biodegradable polyurethane PU (TEG-HMDI) as matrix forming excipient for controlled drug delivery</title><author>Campiñez, María Dolores ; Aguilar-de-Leyva, Ángela ; Ferris, Cristina ; de Paz, M. Violante ; Galbis, Juan Antonio ; Caraballo, Isidoro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-365617a8d00a378ba40791b12fb8e8fda8f3d1b5373360b243447f66947b31113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biodegradable Plastics - chemical synthesis</topic><topic>Biodegradable Plastics - chemistry</topic><topic>biopolymer</topic><topic>Chemical Phenomena</topic><topic>Cyanates - chemistry</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Diffusion</topic><topic>Drug Compounding</topic><topic>Excipients - chemical synthesis</topic><topic>Excipients - chemistry</topic><topic>Hydrophilic matrix</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Indicators and Reagents - chemistry</topic><topic>Isocyanates</topic><topic>Kinetics</topic><topic>Mechanical Phenomena</topic><topic>Models, Molecular</topic><topic>Molecular Structure</topic><topic>Molecular Weight</topic><topic>percolation theory</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyurethanes - chemical synthesis</topic><topic>Polyurethanes - chemistry</topic><topic>Solubility</topic><topic>sustained release</topic><topic>Tablets</topic><topic>Theophylline - chemistry</topic><topic>theophylline anhydrous</topic><topic>Vasodilator Agents - chemistry</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campiñez, María Dolores</creatorcontrib><creatorcontrib>Aguilar-de-Leyva, Ángela</creatorcontrib><creatorcontrib>Ferris, Cristina</creatorcontrib><creatorcontrib>de Paz, M. 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Matrix tablets weighing 250 mg were prepared by direct compression with 10-30% wt/wt of PU(TEG-HMDI) and anhydrous theophylline as model drug. Release studies were carried out using the paddle method. The results were analyzed using the kinetics models of Higuchi, Korsmeyer-Peppas, and Peppas and Sahlin. These studies confirm the existence of an excipient percolation threshold between 10 and 20 % wt/wt of PU(TEG-HMDI) for the different batches prepared. It has been observed that the new biodegradable polyurethane PU(TEG-HMDI) shows adequate compatibility as well as a high ability to control the drug release.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>24087856</pmid><doi>10.3109/03639045.2012.736516</doi><tpages>7</tpages></addata></record> |
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| ispartof | Drug development and industrial pharmacy, 2013-11, Vol.39 (11), p.1758-1764 |
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| source | MEDLINE; EBSCOhost Business Source Complete |
| subjects | Biodegradable Plastics - chemical synthesis Biodegradable Plastics - chemistry biopolymer Chemical Phenomena Cyanates - chemistry Delayed-Action Preparations - chemistry Diffusion Drug Compounding Excipients - chemical synthesis Excipients - chemistry Hydrophilic matrix Hydrophobic and Hydrophilic Interactions Indicators and Reagents - chemistry Isocyanates Kinetics Mechanical Phenomena Models, Molecular Molecular Structure Molecular Weight percolation theory Polyethylene Glycols - chemistry Polyurethanes - chemical synthesis Polyurethanes - chemistry Solubility sustained release Tablets Theophylline - chemistry theophylline anhydrous Vasodilator Agents - chemistry Viscosity |
| title | Study of the properties of the new biodegradable polyurethane PU (TEG-HMDI) as matrix forming excipient for controlled drug delivery |
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