Metastatic or Locally Advanced Colorectal Cancer Treated with 5-Fluorouracil and Low Dose Leucovorin
Eighty-one patients with metastatic or locally advanced colorectal cancer were treated at four oncological centers in Denmark with a regimen consisting of 5-fluorouracil 400 mg/m2 and leucovorin 20 mg/m2 for 5 consecutive days every 4 weeks. The response rate was 21% among all 81 patients (CR 3, PR...
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| Veröffentlicht in: | Acta oncologica 1994, Vol.33 (8), p.931-934 |
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| container_title | Acta oncologica |
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| creator | Andersen, Lisbeth J. Brunsgaard, Niels H. Mejlholm, Inge Jensen, Brita B. |
| description | Eighty-one patients with metastatic or locally advanced colorectal cancer were treated at four oncological centers in Denmark with a regimen consisting of 5-fluorouracil 400 mg/m2 and leucovorin 20 mg/m2 for 5 consecutive days every 4 weeks. The response rate was 21% among all 81 patients (CR 3, PR 14). The median survival was 10 months regardless of measurability, sex and location of disease. Toxicity was mild, 6 (7%) patients were excluded from the study due to gastrointestinal side-effects and 15 (19%) patients had the 5-FU dose reduced due to side-effects. The results are comparable to those of other studies using different doses of leucovorin. |
| doi_str_mv | 10.3109/02841869409098459 |
| format | Article |
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The response rate was 21% among all 81 patients (CR 3, PR 14). The median survival was 10 months regardless of measurability, sex and location of disease. Toxicity was mild, 6 (7%) patients were excluded from the study due to gastrointestinal side-effects and 15 (19%) patients had the 5-FU dose reduced due to side-effects. The results are comparable to those of other studies using different doses of leucovorin.</description><identifier>ISSN: 0284-186X</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.3109/02841869409098459</identifier><identifier>PMID: 7818927</identifier><identifier>CODEN: ACTOEL</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Adult ; Aged ; Antineoplastic agents ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Chemotherapy ; Clinical Trials, Phase III as Topic ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - pathology ; Denmark ; Drug Administration Schedule ; Female ; Fluorouracil - administration & dosage ; Humans ; Leucovorin - administration & dosage ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Survival Analysis ; Treatment Outcome</subject><ispartof>Acta oncologica, 1994, Vol.33 (8), p.931-934</ispartof><rights>1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c372t-65bd3ac34ca532ac999c07598f068e93696dc1ade096169e887d8be92c1cbc423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02841869409098459$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02841869409098459$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3383107$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7818927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andersen, Lisbeth J.</creatorcontrib><creatorcontrib>Brunsgaard, Niels H.</creatorcontrib><creatorcontrib>Mejlholm, Inge</creatorcontrib><creatorcontrib>Jensen, Brita B.</creatorcontrib><title>Metastatic or Locally Advanced Colorectal Cancer Treated with 5-Fluorouracil and Low Dose Leucovorin</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>Eighty-one patients with metastatic or locally advanced colorectal cancer were treated at four oncological centers in Denmark with a regimen consisting of 5-fluorouracil 400 mg/m2 and leucovorin 20 mg/m2 for 5 consecutive days every 4 weeks. The response rate was 21% among all 81 patients (CR 3, PR 14). The median survival was 10 months regardless of measurability, sex and location of disease. Toxicity was mild, 6 (7%) patients were excluded from the study due to gastrointestinal side-effects and 15 (19%) patients had the 5-FU dose reduced due to side-effects. The results are comparable to those of other studies using different doses of leucovorin.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Clinical Trials, Phase III as Topic</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Denmark</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Humans</subject><subject>Leucovorin - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><issn>0284-186X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQx4Mouj4-gAchB6_VPNo0wZOsrgorXhS8lekkZbt0myVpXfz2ZtnFi-BpYP4PZn6EXHJ2Izkzt0zonGtlcmaY0XlhDsiEq4JnQqjPQzLZ6lkyfJ6Q0xiXjDEhy-KYHJeaayPKCbGvboA4wNAi9YHOPULXfdN7-wU9OkunvvPB4QAdnW43gb4HB0NSNu2woEU260Yf_BgA245Cb1PFhj746Ojcjei_fGj7c3LUQBfdxX6ekY_Z4_v0OZu_Pb1M7-cZylIMmSpqKwFljlBIAWiMQVYWRjdMaWekMsoiB-uYUVwZp3Vpde2MQI415kKeEb7rxeBjDK6p1qFdQfiuOKu2wKo_wFLmapdZj_XK2d_EnlDSr_c6xMSmCYlCG39tUupUvLXd7Wxt3_iwgoWDblggBFctE50-vf3PET97tYW6</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Andersen, Lisbeth J.</creator><creator>Brunsgaard, Niels H.</creator><creator>Mejlholm, Inge</creator><creator>Jensen, Brita B.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1994</creationdate><title>Metastatic or Locally Advanced Colorectal Cancer Treated with 5-Fluorouracil and Low Dose Leucovorin</title><author>Andersen, Lisbeth J. ; Brunsgaard, Niels H. ; Mejlholm, Inge ; Jensen, Brita B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-65bd3ac34ca532ac999c07598f068e93696dc1ade096169e887d8be92c1cbc423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Clinical Trials, Phase III as Topic</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Denmark</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Humans</topic><topic>Leucovorin - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andersen, Lisbeth J.</creatorcontrib><creatorcontrib>Brunsgaard, Niels H.</creatorcontrib><creatorcontrib>Mejlholm, Inge</creatorcontrib><creatorcontrib>Jensen, Brita B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andersen, Lisbeth J.</au><au>Brunsgaard, Niels H.</au><au>Mejlholm, Inge</au><au>Jensen, Brita B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metastatic or Locally Advanced Colorectal Cancer Treated with 5-Fluorouracil and Low Dose Leucovorin</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Oncol</addtitle><date>1994</date><risdate>1994</risdate><volume>33</volume><issue>8</issue><spage>931</spage><epage>934</epage><pages>931-934</pages><issn>0284-186X</issn><eissn>1651-226X</eissn><coden>ACTOEL</coden><abstract>Eighty-one patients with metastatic or locally advanced colorectal cancer were treated at four oncological centers in Denmark with a regimen consisting of 5-fluorouracil 400 mg/m2 and leucovorin 20 mg/m2 for 5 consecutive days every 4 weeks. The response rate was 21% among all 81 patients (CR 3, PR 14). The median survival was 10 months regardless of measurability, sex and location of disease. Toxicity was mild, 6 (7%) patients were excluded from the study due to gastrointestinal side-effects and 15 (19%) patients had the 5-FU dose reduced due to side-effects. The results are comparable to those of other studies using different doses of leucovorin.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>7818927</pmid><doi>10.3109/02841869409098459</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0284-186X |
| ispartof | Acta oncologica, 1994, Vol.33 (8), p.931-934 |
| issn | 0284-186X 1651-226X |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_02841869409098459 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy Clinical Trials, Phase III as Topic Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Denmark Drug Administration Schedule Female Fluorouracil - administration & dosage Humans Leucovorin - administration & dosage Male Medical sciences Middle Aged Pharmacology. Drug treatments Survival Analysis Treatment Outcome |
| title | Metastatic or Locally Advanced Colorectal Cancer Treated with 5-Fluorouracil and Low Dose Leucovorin |
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