Combination Chemotherapy of Advanced Squamous Carcinoma of the Head and Neck
Combination chemotherapy in advanced squamous carcinoma of the head and neck resulted in objective remission in 5 of 8 patients, with a median duration of 9 months. In 4 patients, the intravenous chemotherapy was supplemented by regional intra-arterial short-time infusion chemotherapy, by which one...
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| Veröffentlicht in: | Acta oncologica 1977-01, Vol.16 (5), p.385-393 |
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| container_end_page | 393 |
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| container_issue | 5 |
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| container_title | Acta oncologica |
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| creator | Mattsson, W. Hellekant, C. Andréasson, L. |
| description | Combination chemotherapy in advanced squamous carcinoma of the head and neck resulted in objective remission in 5 of 8 patients, with a median duration of 9 months. In 4 patients, the intravenous chemotherapy was supplemented by regional intra-arterial short-time infusion chemotherapy, by which one patient obtained a partial remission and 3 a static disease. The most important results of the methods used were the subjective improvements of the patients. The side-effects were acceptable, and no serious complications were observed. |
| doi_str_mv | 10.3109/02841867709133959 |
| format | Article |
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In 4 patients, the intravenous chemotherapy was supplemented by regional intra-arterial short-time infusion chemotherapy, by which one patient obtained a partial remission and 3 a static disease. The most important results of the methods used were the subjective improvements of the patients. The side-effects were acceptable, and no serious complications were observed.</description><identifier>ISSN: 0284-186X</identifier><identifier>ISSN: 0567-8064</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.3109/02841867709133959</identifier><identifier>PMID: 304655</identifier><language>eng</language><publisher>Sweden: Informa UK Ltd</publisher><subject>Adult ; Aged ; Antineoplastic Agents - therapeutic use ; Carcinoma, Squamous Cell - drug therapy ; Cyclophosphamide - adverse effects ; Cyclophosphamide - therapeutic use ; Doxorubicin - adverse effects ; Doxorubicin - therapeutic use ; Drug Therapy, Combination ; Female ; Head and Neck Neoplasms - drug therapy ; Humans ; Injections, Intra-Arterial ; Injections, Intravenous ; Leucovorin - adverse effects ; Leucovorin - therapeutic use ; Male ; Methotrexate - adverse effects ; Methotrexate - therapeutic use ; Middle Aged ; Neoplasm Recurrence, Local ; Prognosis ; Vincristine - adverse effects ; Vincristine - therapeutic use</subject><ispartof>Acta oncologica, 1977-01, Vol.16 (5), p.385-393</ispartof><rights>1977 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1977</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-c3734188f1fb93b3e23bfe5713d825fb280383dad8df8403d4db7178972488273</citedby><cites>FETCH-LOGICAL-c349t-c3734188f1fb93b3e23bfe5713d825fb280383dad8df8403d4db7178972488273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02841867709133959$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02841867709133959$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,61221,61402</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/304655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mattsson, W.</creatorcontrib><creatorcontrib>Hellekant, C.</creatorcontrib><creatorcontrib>Andréasson, L.</creatorcontrib><title>Combination Chemotherapy of Advanced Squamous Carcinoma of the Head and Neck</title><title>Acta oncologica</title><addtitle>Acta Radiol Ther Phys Biol</addtitle><description>Combination chemotherapy in advanced squamous carcinoma of the head and neck resulted in objective remission in 5 of 8 patients, with a median duration of 9 months. In 4 patients, the intravenous chemotherapy was supplemented by regional intra-arterial short-time infusion chemotherapy, by which one patient obtained a partial remission and 3 a static disease. The most important results of the methods used were the subjective improvements of the patients. The side-effects were acceptable, and no serious complications were observed.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>Doxorubicin - adverse effects</subject><subject>Doxorubicin - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Head and Neck Neoplasms - drug therapy</subject><subject>Humans</subject><subject>Injections, Intra-Arterial</subject><subject>Injections, Intravenous</subject><subject>Leucovorin - adverse effects</subject><subject>Leucovorin - therapeutic use</subject><subject>Male</subject><subject>Methotrexate - adverse effects</subject><subject>Methotrexate - therapeutic use</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Prognosis</subject><subject>Vincristine - adverse effects</subject><subject>Vincristine - therapeutic use</subject><issn>0284-186X</issn><issn>0567-8064</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KxDAUhYP4N44-gOAiL1BNctsmxZUUdYRBFyrMrqRNQjtOkjFthXl7M1TcCG7uXXznHO49CF1Scg2UFDeEiZSKnHNSUIAiKw7QjOYZTRjLV4dotudJFKxO0VnfrwkhDHh2go6BpHmWzdCy9LbunBw673DZauuHVge53WFv8J36kq7RCr9-jtL6scelDE3nvJV7HJV4oaXC0in8rJuPc3Rk5KbXFz97jt4f7t_KRbJ8eXwq75ZJA2kxxMkhXi0MNXUBNWgGtdEZp6AEy0zNBAEBSiqhjEgJqFTVnHJRcJYKwTjMEZ1ym-D7PmhTbUNnZdhVlFT7Xqo_vUTP1eTZjrXV6tcxFRHx7YQ7Z3ywstVyM7SNDLpa-zG4-M4_4d9yg27e</recordid><startdate>19770101</startdate><enddate>19770101</enddate><creator>Mattsson, W.</creator><creator>Hellekant, C.</creator><creator>Andréasson, L.</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19770101</creationdate><title>Combination Chemotherapy of Advanced Squamous Carcinoma of the Head and Neck</title><author>Mattsson, W. ; Hellekant, C. ; Andréasson, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-c3734188f1fb93b3e23bfe5713d825fb280383dad8df8403d4db7178972488273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Cyclophosphamide - adverse effects</topic><topic>Cyclophosphamide - therapeutic use</topic><topic>Doxorubicin - adverse effects</topic><topic>Doxorubicin - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Head and Neck Neoplasms - drug therapy</topic><topic>Humans</topic><topic>Injections, Intra-Arterial</topic><topic>Injections, Intravenous</topic><topic>Leucovorin - adverse effects</topic><topic>Leucovorin - therapeutic use</topic><topic>Male</topic><topic>Methotrexate - adverse effects</topic><topic>Methotrexate - therapeutic use</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Prognosis</topic><topic>Vincristine - adverse effects</topic><topic>Vincristine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mattsson, W.</creatorcontrib><creatorcontrib>Hellekant, C.</creatorcontrib><creatorcontrib>Andréasson, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mattsson, W.</au><au>Hellekant, C.</au><au>Andréasson, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination Chemotherapy of Advanced Squamous Carcinoma of the Head and Neck</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Radiol Ther Phys Biol</addtitle><date>1977-01-01</date><risdate>1977</risdate><volume>16</volume><issue>5</issue><spage>385</spage><epage>393</epage><pages>385-393</pages><issn>0284-186X</issn><issn>0567-8064</issn><eissn>1651-226X</eissn><abstract>Combination chemotherapy in advanced squamous carcinoma of the head and neck resulted in objective remission in 5 of 8 patients, with a median duration of 9 months. In 4 patients, the intravenous chemotherapy was supplemented by regional intra-arterial short-time infusion chemotherapy, by which one patient obtained a partial remission and 3 a static disease. The most important results of the methods used were the subjective improvements of the patients. The side-effects were acceptable, and no serious complications were observed.</abstract><cop>Sweden</cop><pub>Informa UK Ltd</pub><pmid>304655</pmid><doi>10.3109/02841867709133959</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0284-186X |
| ispartof | Acta oncologica, 1977-01, Vol.16 (5), p.385-393 |
| issn | 0284-186X 0567-8064 1651-226X |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_02841867709133959 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Alma/SFX Local Collection |
| subjects | Adult Aged Antineoplastic Agents - therapeutic use Carcinoma, Squamous Cell - drug therapy Cyclophosphamide - adverse effects Cyclophosphamide - therapeutic use Doxorubicin - adverse effects Doxorubicin - therapeutic use Drug Therapy, Combination Female Head and Neck Neoplasms - drug therapy Humans Injections, Intra-Arterial Injections, Intravenous Leucovorin - adverse effects Leucovorin - therapeutic use Male Methotrexate - adverse effects Methotrexate - therapeutic use Middle Aged Neoplasm Recurrence, Local Prognosis Vincristine - adverse effects Vincristine - therapeutic use |
| title | Combination Chemotherapy of Advanced Squamous Carcinoma of the Head and Neck |
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