Anti-interleukin-4 Inhibits Immunoglobulin E Production in a Murine Model of Atopic Asthma

Immunoglobulin E (IgE) plays an important role in allergy, acting as an initiating factor and being involved in its persistence and exacerbations. As interleukin-4 (IL-4) is critical in IgE synthesis, we propose that treatment of mice with monoclonal anti-IL-4 (11B11) prior to active sensitization w...

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Veröffentlicht in:	The Journal of asthma 1997, Vol.34 (3), p.195-201
Hauptverfasser:	Zhou, Chang-Yi, Crocker, I. Caroline, Koenig, Gary, Romero, F. Antonio, Townley, Robert G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic diseases Allergy Animals Anti-IL-4 Antibodies, Monoclonal - pharmacology Asthma Asthma - immunology Asthma - metabolism Biological and medical sciences Cytokines Disease Models, Animal Female Hypersensitivity, Immediate - immunology Hypersensitivity, Immediate - metabolism Immunization Immunoglobulin E Immunoglobulin E - biosynthesis Immunopathology Interleukin-4 - immunology Medical sciences Mice Mice, Inbred BALB C Murine Ovalbumin - immunology Ovalbumin - pharmacology Respiratory and ent allergic diseases Sodium Chloride - immunology Sodium Chloride - pharmacology
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