Pharmacological testing in the laser-induced monkey glaucoma model
Glaucoma was induced in cynomolgus monkeys by photocoagulating the trabecular meshwork with the argon laser. Repeat treatments were often necessary and wide intraocular pressure fluctuations were characteristic. Baseline intraocular pressure was measured with a calibrated pneumatonometer hourly for...
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| Veröffentlicht in: | Current eye research 1985-01, Vol.4 (7), p.775-781 |
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| creator | Lee, Ping-Yu Podos, Steven M. Howard-Williams, Julia R. Severin, Colette H. Rose, Aron D. Siegel, Marc J. |
| description | Glaucoma was induced in cynomolgus monkeys by photocoagulating the trabecular meshwork with the argon laser. Repeat treatments were often necessary and wide intraocular pressure fluctuations were characteristic.
Baseline intraocular pressure was measured with a calibrated pneumatonometer hourly for six hours. On a succeeding day a baseline measurement was made, 50μl of the drug to be tested applied, and six hourly measurements of intraocular pressure repeated. The effects on intraocular pressure of timolol, epinephrine, pilocarpine, vanadate, prostaglandin F2α (PGF2α), forskolin, and corynanthine were tested in at least eight eyes. Significant (p < 0.05) reductions of intraocular pressure were produced by 0.5% timolol, 2% epinephrine, 4% pilocarpine, 1% vanadate, 500 μg of PGF2α and 1% forskolin. Five per cent corynanthine produced no significant lowering of intraocular pressure.
Tonography revealed an increased outflow facility associated with the reduction of intraocular pressure 2 hours after the administration of 4% pilocarpine.
This glaucoma animal model may be useful in investigating agents that lower intraocular pressure by a variety of mechanisms. |
| doi_str_mv | 10.3109/02713688509020033 |
| format | Article |
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Baseline intraocular pressure was measured with a calibrated pneumatonometer hourly for six hours. On a succeeding day a baseline measurement was made, 50μl of the drug to be tested applied, and six hourly measurements of intraocular pressure repeated. The effects on intraocular pressure of timolol, epinephrine, pilocarpine, vanadate, prostaglandin F2α (PGF2α), forskolin, and corynanthine were tested in at least eight eyes. Significant (p < 0.05) reductions of intraocular pressure were produced by 0.5% timolol, 2% epinephrine, 4% pilocarpine, 1% vanadate, 500 μg of PGF2α and 1% forskolin. Five per cent corynanthine produced no significant lowering of intraocular pressure.
Tonography revealed an increased outflow facility associated with the reduction of intraocular pressure 2 hours after the administration of 4% pilocarpine.
This glaucoma animal model may be useful in investigating agents that lower intraocular pressure by a variety of mechanisms.</description><identifier>ISSN: 0271-3683</identifier><identifier>EISSN: 1460-2202</identifier><identifier>DOI: 10.3109/02713688509020033</identifier><identifier>PMID: 3861296</identifier><identifier>CODEN: CEYRDM</identifier><language>eng</language><publisher>Lisse: Informa UK Ltd</publisher><subject>Administration, Topical ; Animals ; Biological and medical sciences ; Colforsin ; Dinoprost ; Diterpenes - therapeutic use ; Epinephrine - therapeutic use ; Eye ; Glaucoma - drug therapy ; Intraocular Pressure - drug effects ; Intraocular Pressure - radiation effects ; Lasers ; Macaca fascicularis ; Medical sciences ; Pharmacology. Drug treatments ; Pilocarpine - therapeutic use ; Prostaglandins F - therapeutic use ; Radiation Injuries, Experimental - drug therapy ; Sodium Chloride - therapeutic use ; Timolol - therapeutic use ; Vanadates ; Vanadium - therapeutic use ; Yohimbine - therapeutic use</subject><ispartof>Current eye research, 1985-01, Vol.4 (7), p.775-781</ispartof><rights>1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-695bb214a42fe70e28cc92d903126c7dd54a28c08ba7fbaf22aba79f87b394c13</citedby><cites>FETCH-LOGICAL-c525t-695bb214a42fe70e28cc92d903126c7dd54a28c08ba7fbaf22aba79f87b394c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02713688509020033$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02713688509020033$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8654761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3861296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Ping-Yu</creatorcontrib><creatorcontrib>Podos, Steven M.</creatorcontrib><creatorcontrib>Howard-Williams, Julia R.</creatorcontrib><creatorcontrib>Severin, Colette H.</creatorcontrib><creatorcontrib>Rose, Aron D.</creatorcontrib><creatorcontrib>Siegel, Marc J.</creatorcontrib><title>Pharmacological testing in the laser-induced monkey glaucoma model</title><title>Current eye research</title><addtitle>Curr Eye Res</addtitle><description>Glaucoma was induced in cynomolgus monkeys by photocoagulating the trabecular meshwork with the argon laser. Repeat treatments were often necessary and wide intraocular pressure fluctuations were characteristic.
Baseline intraocular pressure was measured with a calibrated pneumatonometer hourly for six hours. On a succeeding day a baseline measurement was made, 50μl of the drug to be tested applied, and six hourly measurements of intraocular pressure repeated. The effects on intraocular pressure of timolol, epinephrine, pilocarpine, vanadate, prostaglandin F2α (PGF2α), forskolin, and corynanthine were tested in at least eight eyes. Significant (p < 0.05) reductions of intraocular pressure were produced by 0.5% timolol, 2% epinephrine, 4% pilocarpine, 1% vanadate, 500 μg of PGF2α and 1% forskolin. Five per cent corynanthine produced no significant lowering of intraocular pressure.
Tonography revealed an increased outflow facility associated with the reduction of intraocular pressure 2 hours after the administration of 4% pilocarpine.
This glaucoma animal model may be useful in investigating agents that lower intraocular pressure by a variety of mechanisms.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colforsin</subject><subject>Dinoprost</subject><subject>Diterpenes - therapeutic use</subject><subject>Epinephrine - therapeutic use</subject><subject>Eye</subject><subject>Glaucoma - drug therapy</subject><subject>Intraocular Pressure - drug effects</subject><subject>Intraocular Pressure - radiation effects</subject><subject>Lasers</subject><subject>Macaca fascicularis</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pilocarpine - therapeutic use</subject><subject>Prostaglandins F - therapeutic use</subject><subject>Radiation Injuries, Experimental - drug therapy</subject><subject>Sodium Chloride - therapeutic use</subject><subject>Timolol - therapeutic use</subject><subject>Vanadates</subject><subject>Vanadium - therapeutic use</subject><subject>Yohimbine - therapeutic use</subject><issn>0271-3683</issn><issn>1460-2202</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4zj6A1wIXbit5tGmLbrRwRcM6ELX5TaPace0kaRF5t-bMuOACLNKcs_5kpyD0DnBV4zg4hrTjDCe5ykuMMWYsQM0JQnHMaWYHqLpqMfBwI7RifcrjMdBMkETlnNCCz5F9281uBaENXbZCDBRr3zfdMuo6aK-VpEBr1zcdHIQSkat7T7VOloaGIRtIZylMqfoSIPx6my7ztDH48P7_DlevD69zO8WsUhp2se8SKuKkgQSqlWGFc2FKKgsMCOUi0zKNIEww3kFma5AUwphV-g8q1iRCMJmiGzuFc5675Quv1zTgluXBJdjHeW_OgJzsWG-hqpVckds8wf9cquDD-m1g040fmfLeZpkfHz6dmNrOm1DXd_WGVn2sDbW_TJs3y9u_uC1AtPXApwqV3ZwXWhtT4YfT3SMeQ</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Lee, Ping-Yu</creator><creator>Podos, Steven M.</creator><creator>Howard-Williams, Julia R.</creator><creator>Severin, Colette H.</creator><creator>Rose, Aron D.</creator><creator>Siegel, Marc J.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Swets & Zeitlinger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19850101</creationdate><title>Pharmacological testing in the laser-induced monkey glaucoma model</title><author>Lee, Ping-Yu ; Podos, Steven M. ; Howard-Williams, Julia R. ; Severin, Colette H. ; Rose, Aron D. ; Siegel, Marc J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-695bb214a42fe70e28cc92d903126c7dd54a28c08ba7fbaf22aba79f87b394c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colforsin</topic><topic>Dinoprost</topic><topic>Diterpenes - therapeutic use</topic><topic>Epinephrine - therapeutic use</topic><topic>Eye</topic><topic>Glaucoma - drug therapy</topic><topic>Intraocular Pressure - drug effects</topic><topic>Intraocular Pressure - radiation effects</topic><topic>Lasers</topic><topic>Macaca fascicularis</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Pilocarpine - therapeutic use</topic><topic>Prostaglandins F - therapeutic use</topic><topic>Radiation Injuries, Experimental - drug therapy</topic><topic>Sodium Chloride - therapeutic use</topic><topic>Timolol - therapeutic use</topic><topic>Vanadates</topic><topic>Vanadium - therapeutic use</topic><topic>Yohimbine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Ping-Yu</creatorcontrib><creatorcontrib>Podos, Steven M.</creatorcontrib><creatorcontrib>Howard-Williams, Julia R.</creatorcontrib><creatorcontrib>Severin, Colette H.</creatorcontrib><creatorcontrib>Rose, Aron D.</creatorcontrib><creatorcontrib>Siegel, Marc J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Current eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Ping-Yu</au><au>Podos, Steven M.</au><au>Howard-Williams, Julia R.</au><au>Severin, Colette H.</au><au>Rose, Aron D.</au><au>Siegel, Marc J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological testing in the laser-induced monkey glaucoma model</atitle><jtitle>Current eye research</jtitle><addtitle>Curr Eye Res</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>4</volume><issue>7</issue><spage>775</spage><epage>781</epage><pages>775-781</pages><issn>0271-3683</issn><eissn>1460-2202</eissn><coden>CEYRDM</coden><abstract>Glaucoma was induced in cynomolgus monkeys by photocoagulating the trabecular meshwork with the argon laser. Repeat treatments were often necessary and wide intraocular pressure fluctuations were characteristic.
Baseline intraocular pressure was measured with a calibrated pneumatonometer hourly for six hours. On a succeeding day a baseline measurement was made, 50μl of the drug to be tested applied, and six hourly measurements of intraocular pressure repeated. The effects on intraocular pressure of timolol, epinephrine, pilocarpine, vanadate, prostaglandin F2α (PGF2α), forskolin, and corynanthine were tested in at least eight eyes. Significant (p < 0.05) reductions of intraocular pressure were produced by 0.5% timolol, 2% epinephrine, 4% pilocarpine, 1% vanadate, 500 μg of PGF2α and 1% forskolin. Five per cent corynanthine produced no significant lowering of intraocular pressure.
Tonography revealed an increased outflow facility associated with the reduction of intraocular pressure 2 hours after the administration of 4% pilocarpine.
This glaucoma animal model may be useful in investigating agents that lower intraocular pressure by a variety of mechanisms.</abstract><cop>Lisse</cop><pub>Informa UK Ltd</pub><pmid>3861296</pmid><doi>10.3109/02713688509020033</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0271-3683 |
| ispartof | Current eye research, 1985-01, Vol.4 (7), p.775-781 |
| issn | 0271-3683 1460-2202 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Administration, Topical Animals Biological and medical sciences Colforsin Dinoprost Diterpenes - therapeutic use Epinephrine - therapeutic use Eye Glaucoma - drug therapy Intraocular Pressure - drug effects Intraocular Pressure - radiation effects Lasers Macaca fascicularis Medical sciences Pharmacology. Drug treatments Pilocarpine - therapeutic use Prostaglandins F - therapeutic use Radiation Injuries, Experimental - drug therapy Sodium Chloride - therapeutic use Timolol - therapeutic use Vanadates Vanadium - therapeutic use Yohimbine - therapeutic use |
| title | Pharmacological testing in the laser-induced monkey glaucoma model |
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