Solid and Papillary Neoplasm of the Pancreas
In two cases of solid and papillary neoplasm of the pancreas (SPN), positive staining for argyrophil granules, chromogranin-A, neuron-specific enolase, chymotrypsin, α1-antitrypsin, vimentin, cytokeratin, and estrogen receptors was present. Ultrastructurally, neurosecretory as well as zymogenlike gr...
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| Veröffentlicht in: | Ultrastructural pathology 1992, Vol.16 (6), p.659-666 |
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| container_title | Ultrastructural pathology |
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| creator | Jøsrgensen, Lars J. Hansen, Alastair B. Burcharth, Flemming Philipsen, Else Horn, Thomas |
| description | In two cases of solid and papillary neoplasm of the pancreas (SPN), positive staining for argyrophil granules, chromogranin-A, neuron-specific enolase, chymotrypsin, α1-antitrypsin, vimentin, cytokeratin, and estrogen receptors was present. Ultrastructurally, neurosecretory as well as zymogenlike granules were demonstrated. Measurements of mean nuclear volume and volume-corrected mitotic index discriminated between SPN and well-differentiated ductal adenocarcinoma of the pancreas, with notably lower values being seen in SPN. Silver-stained nucleolar organizer region counts showed wide overlaps. The results suggest that SPN is a tumor with mixed endocrine and exocrine features. Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful. |
| doi_str_mv | 10.3109/01913129209023755 |
| format | Article |
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Ultrastructurally, neurosecretory as well as zymogenlike granules were demonstrated. Measurements of mean nuclear volume and volume-corrected mitotic index discriminated between SPN and well-differentiated ductal adenocarcinoma of the pancreas, with notably lower values being seen in SPN. Silver-stained nucleolar organizer region counts showed wide overlaps. The results suggest that SPN is a tumor with mixed endocrine and exocrine features. Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful.</description><identifier>ISSN: 0191-3123</identifier><identifier>EISSN: 1521-0758</identifier><identifier>DOI: 10.3109/01913129209023755</identifier><identifier>PMID: 1448885</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adolescent ; Adult ; Chymotrypsin - analysis ; DNA-Binding Proteins - analysis ; Female ; Humans ; immunohistochemistry ; Microscopy, Electron ; morphometry ; Pancreatic Neoplasms - chemistry ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - ultrastructure ; pancreatic solid papillary neoplasm ; Phosphopyruvate Hydratase - analysis ; ultrastructure</subject><ispartof>Ultrastructural pathology, 1992, Vol.16 (6), p.659-666</ispartof><rights>1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-d7df99a43552d65ce95c088d1b1efa265ef8bb2824f3bfff74d971d199df5c163</citedby><cites>FETCH-LOGICAL-c496t-d7df99a43552d65ce95c088d1b1efa265ef8bb2824f3bfff74d971d199df5c163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/01913129209023755$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/01913129209023755$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1448885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jøsrgensen, Lars J.</creatorcontrib><creatorcontrib>Hansen, Alastair B.</creatorcontrib><creatorcontrib>Burcharth, Flemming</creatorcontrib><creatorcontrib>Philipsen, Else</creatorcontrib><creatorcontrib>Horn, Thomas</creatorcontrib><title>Solid and Papillary Neoplasm of the Pancreas</title><title>Ultrastructural pathology</title><addtitle>Ultrastruct Pathol</addtitle><description>In two cases of solid and papillary neoplasm of the pancreas (SPN), positive staining for argyrophil granules, chromogranin-A, neuron-specific enolase, chymotrypsin, α1-antitrypsin, vimentin, cytokeratin, and estrogen receptors was present. Ultrastructurally, neurosecretory as well as zymogenlike granules were demonstrated. Measurements of mean nuclear volume and volume-corrected mitotic index discriminated between SPN and well-differentiated ductal adenocarcinoma of the pancreas, with notably lower values being seen in SPN. Silver-stained nucleolar organizer region counts showed wide overlaps. The results suggest that SPN is a tumor with mixed endocrine and exocrine features. Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Chymotrypsin - analysis</subject><subject>DNA-Binding Proteins - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Microscopy, Electron</subject><subject>morphometry</subject><subject>Pancreatic Neoplasms - chemistry</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - ultrastructure</subject><subject>pancreatic solid papillary neoplasm</subject><subject>Phosphopyruvate Hydratase - analysis</subject><subject>ultrastructure</subject><issn>0191-3123</issn><issn>1521-0758</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4zj6A1wIXbmymkfTJuhGBl8wqKCuQ5oH0yFtxqRF5t-boYKI6Oouzj2Hcz4AjhE8JwjyC4g4IghzDDnEpKJ0B0wRxSiHFWW7YLrV8_RA9sFBjCsIISWQTcAEFQVjjE7B2Yt3jc5kp7NnuW6ck2GTPRq_djK2mbdZvzRJ6VQwMh6CPStdNEdfdwbebm9e5_f54unuYX69yFXByz7Xlbacy4JQinVJleFUQcY0qpGxEpfUWFbXmOHCktpaWxWaV0gjzrWlCpVkBk7H3HXw74OJvWibqEwq1xk_RFERUiCetswAGh9V8DEGY8U6NG2aIBAUW0LiF6HkOfkKH-rW6G_HiCTpV6PedNaHVn744LTo5cb5YEMi0cRt9N_xlz_sSyNdv1QyGLHyQ-gSt3_KfQIQ2ISx</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Jøsrgensen, Lars J.</creator><creator>Hansen, Alastair B.</creator><creator>Burcharth, Flemming</creator><creator>Philipsen, Else</creator><creator>Horn, Thomas</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Solid and Papillary Neoplasm of the Pancreas</title><author>Jøsrgensen, Lars J. ; Hansen, Alastair B. ; Burcharth, Flemming ; Philipsen, Else ; Horn, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-d7df99a43552d65ce95c088d1b1efa265ef8bb2824f3bfff74d971d199df5c163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Chymotrypsin - analysis</topic><topic>DNA-Binding Proteins - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Microscopy, Electron</topic><topic>morphometry</topic><topic>Pancreatic Neoplasms - chemistry</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - ultrastructure</topic><topic>pancreatic solid papillary neoplasm</topic><topic>Phosphopyruvate Hydratase - analysis</topic><topic>ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jøsrgensen, Lars J.</creatorcontrib><creatorcontrib>Hansen, Alastair B.</creatorcontrib><creatorcontrib>Burcharth, Flemming</creatorcontrib><creatorcontrib>Philipsen, Else</creatorcontrib><creatorcontrib>Horn, Thomas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrastructural pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jøsrgensen, Lars J.</au><au>Hansen, Alastair B.</au><au>Burcharth, Flemming</au><au>Philipsen, Else</au><au>Horn, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solid and Papillary Neoplasm of the Pancreas</atitle><jtitle>Ultrastructural pathology</jtitle><addtitle>Ultrastruct Pathol</addtitle><date>1992</date><risdate>1992</risdate><volume>16</volume><issue>6</issue><spage>659</spage><epage>666</epage><pages>659-666</pages><issn>0191-3123</issn><eissn>1521-0758</eissn><abstract>In two cases of solid and papillary neoplasm of the pancreas (SPN), positive staining for argyrophil granules, chromogranin-A, neuron-specific enolase, chymotrypsin, α1-antitrypsin, vimentin, cytokeratin, and estrogen receptors was present. Ultrastructurally, neurosecretory as well as zymogenlike granules were demonstrated. Measurements of mean nuclear volume and volume-corrected mitotic index discriminated between SPN and well-differentiated ductal adenocarcinoma of the pancreas, with notably lower values being seen in SPN. Silver-stained nucleolar organizer region counts showed wide overlaps. The results suggest that SPN is a tumor with mixed endocrine and exocrine features. Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>1448885</pmid><doi>10.3109/01913129209023755</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0191-3123 |
| ispartof | Ultrastructural pathology, 1992, Vol.16 (6), p.659-666 |
| issn | 0191-3123 1521-0758 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adolescent Adult Chymotrypsin - analysis DNA-Binding Proteins - analysis Female Humans immunohistochemistry Microscopy, Electron morphometry Pancreatic Neoplasms - chemistry Pancreatic Neoplasms - pathology Pancreatic Neoplasms - ultrastructure pancreatic solid papillary neoplasm Phosphopyruvate Hydratase - analysis ultrastructure |
| title | Solid and Papillary Neoplasm of the Pancreas |
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