The use of single sample clearance estimates to probe hepatic drug metabolism: Handprinting the influence of phenobarbitone on human hepatic drug metabolism

1. Single sample clearance estimates, CL, were calculated for seven drugs employed as probes of human hepatic drug-metabolizing enzymes. Clearance estimates were calculated in healthy young adult male volunteers either taking no pretreatment, or taking phenobarbitone (PB) 100 mg nightly for 3 nights...

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Veröffentlicht in:	Xenobiotica 1991, Vol.21 (10), p.1385-1392
Hauptverfasser:	Bachmann, K. A., Nunlee, M., Martin, M., Jaregui, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Cytochrome P-450 Enzyme System - metabolism General pharmacology Humans Liver - drug effects Liver - metabolism Male Medical sciences Metabolic Clearance Rate Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Phenobarbital - pharmacology Xenobiotics - metabolism
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