Studies on the Metabolism of 3-O-tert.-Butylmorphine, a New Morphine Derivative, by the Rat

1. The O-dealkylation of 3-O-tert.-butylmorphine, a new derivative of morphine, has been compared to the O-dealkylation of codeine by the rat. Rats were given either 3-O-tert.-butylmorphine or codeine intraperitoneally and 24 h urine samples were collected and analysed for morphine by a quantitative...

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Veröffentlicht in:	Xenobiotica 1971, Vol.1 (3), p.273-285
Hauptverfasser:	Kamm, Jerome J., Bastone, Vivian B., Mohacsi, Erno, Vane, Floie M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Gas Codeine - isolation & purification Codeine - metabolism Codeine - urine Dealkylation Drug Stability Glucuronidase Hydrolysis Male Mass Spectrometry Mathematics Models, Structural Morphinans - isolation & purification Morphinans - metabolism Morphinans - urine Morphine - urine Oxidation-Reduction Rats Sulfatases
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