Urothelial Atypia and Survival Rate of 500 Unselected Patients with Primary Transitional-Cell Tumour of the Urinary Bladder
In a consecutive series of 500 unselected patients with primary urinary bladder tumours the influence of urothelial atypia on the 5 years survival-rate was examined. All tumours were transitional-cell tumours categorized according to the T-classification. Mucosal biopsies from 7 preselected sites we...
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| Veröffentlicht in: | Scandinavian journal of urology and nephrology 1988, Vol.22 (4), p.257-263 |
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| container_title | Scandinavian journal of urology and nephrology |
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| creator | Rosenkilde Olsen, Palle Wolf, Hans Schroeder, Torben Fischer, Anders Højgaard, Knud |
| description | In a consecutive series of 500 unselected patients with primary urinary bladder tumours the influence of urothelial atypia on the 5 years survival-rate was examined. All tumours were transitional-cell tumours categorized according to the T-classification. Mucosal biopsies from 7 preselected sites were taken at the initial cystoscopy in 391 patients (78%) to identify urothelial atypia. The over-all cumulative 5 years survival-rate was 48%. Submucosal and muscle invasion had major influence on survival, whereas tumour grade was less important. Patients with urothelial atypia fared significantly worse than those with normal bladder mucosa (5 years survival 42% versus 62%). This difference in survival-rate became apparent first after two years of observation. Grade II atypia in the bladder mucosa and grade III (carcinoma in situ) had equal significance assessed by the survival-rates. |
| doi_str_mv | 10.3109/00365598809180796 |
| format | Article |
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All tumours were transitional-cell tumours categorized according to the T-classification. Mucosal biopsies from 7 preselected sites were taken at the initial cystoscopy in 391 patients (78%) to identify urothelial atypia. The over-all cumulative 5 years survival-rate was 48%. Submucosal and muscle invasion had major influence on survival, whereas tumour grade was less important. Patients with urothelial atypia fared significantly worse than those with normal bladder mucosa (5 years survival 42% versus 62%). This difference in survival-rate became apparent first after two years of observation. Grade II atypia in the bladder mucosa and grade III (carcinoma in situ) had equal significance assessed by the survival-rates.</description><identifier>ISSN: 0036-5599</identifier><identifier>EISSN: 1651-2065</identifier><identifier>DOI: 10.3109/00365598809180796</identifier><identifier>PMID: 3238330</identifier><identifier>CODEN: SJUNAS</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; bladder tumours ; Carcinoma, Transitional Cell - mortality ; Carcinoma, Transitional Cell - pathology ; Endothelium - pathology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; survival-rate ; transitional-cell carcinoma ; Tumors of the urinary system ; Urinary Bladder - pathology ; Urinary Bladder Neoplasms - mortality ; Urinary Bladder Neoplasms - pathology ; Urinary tract. Prostate gland ; urothelial atypia</subject><ispartof>Scandinavian journal of urology and nephrology, 1988, Vol.22 (4), p.257-263</ispartof><rights>1988 Informa UK Ltd 1988</rights><rights>1989 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-8766376fb3822fdb090c517ccd23474bd7b8c316f5951ebb92901dc815185b703</citedby><cites>FETCH-LOGICAL-c430t-8766376fb3822fdb090c517ccd23474bd7b8c316f5951ebb92901dc815185b703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365598809180796$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365598809180796$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4009,27902,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7112546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3238330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenkilde Olsen, Palle</creatorcontrib><creatorcontrib>Wolf, Hans</creatorcontrib><creatorcontrib>Schroeder, Torben</creatorcontrib><creatorcontrib>Fischer, Anders</creatorcontrib><creatorcontrib>Højgaard, Knud</creatorcontrib><title>Urothelial Atypia and Survival Rate of 500 Unselected Patients with Primary Transitional-Cell Tumour of the Urinary Bladder</title><title>Scandinavian journal of urology and nephrology</title><addtitle>Scand J Urol Nephrol</addtitle><description>In a consecutive series of 500 unselected patients with primary urinary bladder tumours the influence of urothelial atypia on the 5 years survival-rate was examined. All tumours were transitional-cell tumours categorized according to the T-classification. Mucosal biopsies from 7 preselected sites were taken at the initial cystoscopy in 391 patients (78%) to identify urothelial atypia. The over-all cumulative 5 years survival-rate was 48%. Submucosal and muscle invasion had major influence on survival, whereas tumour grade was less important. Patients with urothelial atypia fared significantly worse than those with normal bladder mucosa (5 years survival 42% versus 62%). This difference in survival-rate became apparent first after two years of observation. Grade II atypia in the bladder mucosa and grade III (carcinoma in situ) had equal significance assessed by the survival-rates.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>bladder tumours</subject><subject>Carcinoma, Transitional Cell - mortality</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Endothelium - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>survival-rate</subject><subject>transitional-cell carcinoma</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder - pathology</subject><subject>Urinary Bladder Neoplasms - mortality</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary tract. Prostate gland</subject><subject>urothelial atypia</subject><issn>0036-5599</issn><issn>1651-2065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV9rFDEUxYModa1-AB-EPIhvozeTzZ9BX-pSrVBoqbvPQybJsCmZyZpkWpZ--WbYtSBCnwL3_s7Jveci9J7AZ0qg-QJAOWONlNAQCaLhL9CCcEaqGjh7iRZzvypA8xq9SekWAGpO-Ak6oTWVlMICPWxiyFvrnfL4LO93TmE1Gvx7infurtRuVLY49JgB4M2YrLc6W4OvVXZ2zAnfu7zF19ENKu7xOqoxuezCqHy1st7j9TSEKc4G5RO8iW6cue9eGWPjW_SqVz7Zd8f3FG1-nK9XF9Xl1c9fq7PLSi8p5EoKzqngfUdlXfemgwY0I0JrU9OlWHZGdFJTwnvWMGK7rqkbIEZLwohknQB6ij4dfHcx_Jlsyu3gki7jqdGGKbVCihqokAUkB1DHkFK0fbs7bNYSaOfA2_8CL5oPR_OpG6x5UhwTLv2Px75KWvm-RKRdesIEITVbzjbfDpgb-xAHdR-iN21Wex_iXw19boqv_8i3Vvm81Sra9rYcoNwjPbPDI1D6rR4</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Rosenkilde Olsen, Palle</creator><creator>Wolf, Hans</creator><creator>Schroeder, Torben</creator><creator>Fischer, Anders</creator><creator>Højgaard, Knud</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Urothelial Atypia and Survival Rate of 500 Unselected Patients with Primary Transitional-Cell Tumour of the Urinary Bladder</title><author>Rosenkilde Olsen, Palle ; Wolf, Hans ; Schroeder, Torben ; Fischer, Anders ; Højgaard, Knud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-8766376fb3822fdb090c517ccd23474bd7b8c316f5951ebb92901dc815185b703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>bladder tumours</topic><topic>Carcinoma, Transitional Cell - mortality</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Endothelium - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>survival-rate</topic><topic>transitional-cell carcinoma</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder - pathology</topic><topic>Urinary Bladder Neoplasms - mortality</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary tract. Prostate gland</topic><topic>urothelial atypia</topic><toplevel>online_resources</toplevel><creatorcontrib>Rosenkilde Olsen, Palle</creatorcontrib><creatorcontrib>Wolf, Hans</creatorcontrib><creatorcontrib>Schroeder, Torben</creatorcontrib><creatorcontrib>Fischer, Anders</creatorcontrib><creatorcontrib>Højgaard, Knud</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenkilde Olsen, Palle</au><au>Wolf, Hans</au><au>Schroeder, Torben</au><au>Fischer, Anders</au><au>Højgaard, Knud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urothelial Atypia and Survival Rate of 500 Unselected Patients with Primary Transitional-Cell Tumour of the Urinary Bladder</atitle><jtitle>Scandinavian journal of urology and nephrology</jtitle><addtitle>Scand J Urol Nephrol</addtitle><date>1988</date><risdate>1988</risdate><volume>22</volume><issue>4</issue><spage>257</spage><epage>263</epage><pages>257-263</pages><issn>0036-5599</issn><eissn>1651-2065</eissn><coden>SJUNAS</coden><abstract>In a consecutive series of 500 unselected patients with primary urinary bladder tumours the influence of urothelial atypia on the 5 years survival-rate was examined. All tumours were transitional-cell tumours categorized according to the T-classification. Mucosal biopsies from 7 preselected sites were taken at the initial cystoscopy in 391 patients (78%) to identify urothelial atypia. The over-all cumulative 5 years survival-rate was 48%. Submucosal and muscle invasion had major influence on survival, whereas tumour grade was less important. Patients with urothelial atypia fared significantly worse than those with normal bladder mucosa (5 years survival 42% versus 62%). This difference in survival-rate became apparent first after two years of observation. Grade II atypia in the bladder mucosa and grade III (carcinoma in situ) had equal significance assessed by the survival-rates.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>3238330</pmid><doi>10.3109/00365598809180796</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-5599 |
| ispartof | Scandinavian journal of urology and nephrology, 1988, Vol.22 (4), p.257-263 |
| issn | 0036-5599 1651-2065 |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_00365598809180796 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Aged Biological and medical sciences bladder tumours Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Endothelium - pathology Female Humans Male Medical sciences Middle Aged Nephrology. Urinary tract diseases survival-rate transitional-cell carcinoma Tumors of the urinary system Urinary Bladder - pathology Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology Urinary tract. Prostate gland urothelial atypia |
| title | Urothelial Atypia and Survival Rate of 500 Unselected Patients with Primary Transitional-Cell Tumour of the Urinary Bladder |
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