The Vagogastrone Mechanism in Man
From experiments on the dog evidence has accumulated of vagal release of a candidate hormone inhibiting gastric acid secretion-vagogastrone. The nature and origin of vagogastrone are uncertain. The inhibitory effect of vagogastrone is characteristically exerted against gastrin-stimulated acid secret...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1978-01, Vol.13 (8), p.895-901 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | Stenquist, B. Knutson, U. Olbe, L. |
| description | From experiments on the dog evidence has accumulated of vagal release of a candidate hormone inhibiting gastric acid secretion-vagogastrone. The nature and origin of vagogastrone are uncertain. The inhibitory effect of vagogastrone is characteristically exerted against gastrin-stimulated acid secretion from the vagally denervated parietal cell area. In the present study vagal activation by sham feeding significantly inhibited the submaximal acid response to continuous i.v. infusion of pentagastrin in seven duodenal ulcer patients previously subjected to proximal gastric vagotomy. The inhibitory effect was slight-16% reduction-and of short duration. Sham feeding had no effect on the pentagastrin-stimulated acid secretion in six subjects with an intact stomach. The results favour the existence of a vagogastrone mechanism in man, but the inhibitory effect seems to be of quantitatively minor importance, at least in the duodenal ulcer patient. |
| doi_str_mv | 10.3109/00365527809181366 |
| format | Article |
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The nature and origin of vagogastrone are uncertain. The inhibitory effect of vagogastrone is characteristically exerted against gastrin-stimulated acid secretion from the vagally denervated parietal cell area. In the present study vagal activation by sham feeding significantly inhibited the submaximal acid response to continuous i.v. infusion of pentagastrin in seven duodenal ulcer patients previously subjected to proximal gastric vagotomy. The inhibitory effect was slight-16% reduction-and of short duration. Sham feeding had no effect on the pentagastrin-stimulated acid secretion in six subjects with an intact stomach. The results favour the existence of a vagogastrone mechanism in man, but the inhibitory effect seems to be of quantitatively minor importance, at least in the duodenal ulcer patient.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.3109/00365527809181366</identifier><identifier>PMID: 725513</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Aged ; Duodenal ulcer ; Duodenal Ulcer - physiopathology ; Female ; Food ; gastric acidity determination ; Gastric Juice - metabolism ; Gastrointestinal Hormones - metabolism ; Humans ; Insulin ; Male ; Middle Aged ; pentagastrin ; Pentagastrin - pharmacology ; Recurrence ; Vagotomy ; vagus nerve ; Vagus Nerve - metabolism</subject><ispartof>Scandinavian journal of gastroenterology, 1978-01, Vol.13 (8), p.895-901</ispartof><rights>1978 Informa UK Ltd 1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-4565ec6fa75f07e21cd2299121ed7530547bd52bf6e13c10f4164df2117a57bd3</citedby><cites>FETCH-LOGICAL-c400t-4565ec6fa75f07e21cd2299121ed7530547bd52bf6e13c10f4164df2117a57bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365527809181366$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365527809181366$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/725513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stenquist, B.</creatorcontrib><creatorcontrib>Knutson, U.</creatorcontrib><creatorcontrib>Olbe, L.</creatorcontrib><title>The Vagogastrone Mechanism in Man</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>From experiments on the dog evidence has accumulated of vagal release of a candidate hormone inhibiting gastric acid secretion-vagogastrone. The nature and origin of vagogastrone are uncertain. The inhibitory effect of vagogastrone is characteristically exerted against gastrin-stimulated acid secretion from the vagally denervated parietal cell area. In the present study vagal activation by sham feeding significantly inhibited the submaximal acid response to continuous i.v. infusion of pentagastrin in seven duodenal ulcer patients previously subjected to proximal gastric vagotomy. The inhibitory effect was slight-16% reduction-and of short duration. Sham feeding had no effect on the pentagastrin-stimulated acid secretion in six subjects with an intact stomach. The results favour the existence of a vagogastrone mechanism in man, but the inhibitory effect seems to be of quantitatively minor importance, at least in the duodenal ulcer patient.</description><subject>Adult</subject><subject>Aged</subject><subject>Duodenal ulcer</subject><subject>Duodenal Ulcer - physiopathology</subject><subject>Female</subject><subject>Food</subject><subject>gastric acidity determination</subject><subject>Gastric Juice - metabolism</subject><subject>Gastrointestinal Hormones - metabolism</subject><subject>Humans</subject><subject>Insulin</subject><subject>Male</subject><subject>Middle Aged</subject><subject>pentagastrin</subject><subject>Pentagastrin - pharmacology</subject><subject>Recurrence</subject><subject>Vagotomy</subject><subject>vagus nerve</subject><subject>Vagus Nerve - metabolism</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQfxVas_QHARN-6i904ymQTdSPEFLW6q2zCdzDQpyUydSZD-e1NSBBFd3cV3zsflEHKOcB0hZDcAUcIY5SlkmGKUJHtkhAxoyDmk-2S05WEfwGNy4v0KABiPsyNyyCljGI3I5bxUwbtY2qXwrbNGBTMlS2Eq3wSVCWbCnJIDLWqvznZ3TN4eH-aT53D6-vQyuZ-GMgZow5glTMlEC840cEVRFpRmGVJUBWcRsJgvCkYXOlEYSQQdYxIXmiJywXoUjcnV4F07-9Ep3-ZN5aWqa2GU7XzOY5oxhLQP4hCUznrvlM7XrmqE2-QI-XaV_NcqfediJ-8WjSq-G8MMPb4bcGW0dY34tK4u8lZsauu0E0ZWfmv-2377o14qUbelFE7lK9s508_2z29fP9B_Lg</recordid><startdate>19780101</startdate><enddate>19780101</enddate><creator>Stenquist, B.</creator><creator>Knutson, U.</creator><creator>Olbe, L.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780101</creationdate><title>The Vagogastrone Mechanism in Man</title><author>Stenquist, B. ; Knutson, U. ; Olbe, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-4565ec6fa75f07e21cd2299121ed7530547bd52bf6e13c10f4164df2117a57bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Duodenal ulcer</topic><topic>Duodenal Ulcer - physiopathology</topic><topic>Female</topic><topic>Food</topic><topic>gastric acidity determination</topic><topic>Gastric Juice - metabolism</topic><topic>Gastrointestinal Hormones - metabolism</topic><topic>Humans</topic><topic>Insulin</topic><topic>Male</topic><topic>Middle Aged</topic><topic>pentagastrin</topic><topic>Pentagastrin - pharmacology</topic><topic>Recurrence</topic><topic>Vagotomy</topic><topic>vagus nerve</topic><topic>Vagus Nerve - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stenquist, B.</creatorcontrib><creatorcontrib>Knutson, U.</creatorcontrib><creatorcontrib>Olbe, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stenquist, B.</au><au>Knutson, U.</au><au>Olbe, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Vagogastrone Mechanism in Man</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1978-01-01</date><risdate>1978</risdate><volume>13</volume><issue>8</issue><spage>895</spage><epage>901</epage><pages>895-901</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><abstract>From experiments on the dog evidence has accumulated of vagal release of a candidate hormone inhibiting gastric acid secretion-vagogastrone. The nature and origin of vagogastrone are uncertain. The inhibitory effect of vagogastrone is characteristically exerted against gastrin-stimulated acid secretion from the vagally denervated parietal cell area. In the present study vagal activation by sham feeding significantly inhibited the submaximal acid response to continuous i.v. infusion of pentagastrin in seven duodenal ulcer patients previously subjected to proximal gastric vagotomy. The inhibitory effect was slight-16% reduction-and of short duration. Sham feeding had no effect on the pentagastrin-stimulated acid secretion in six subjects with an intact stomach. The results favour the existence of a vagogastrone mechanism in man, but the inhibitory effect seems to be of quantitatively minor importance, at least in the duodenal ulcer patient.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>725513</pmid><doi>10.3109/00365527809181366</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-5521 |
| ispartof | Scandinavian journal of gastroenterology, 1978-01, Vol.13 (8), p.895-901 |
| issn | 0036-5521 1502-7708 |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_00365527809181366 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Aged Duodenal ulcer Duodenal Ulcer - physiopathology Female Food gastric acidity determination Gastric Juice - metabolism Gastrointestinal Hormones - metabolism Humans Insulin Male Middle Aged pentagastrin Pentagastrin - pharmacology Recurrence Vagotomy vagus nerve Vagus Nerve - metabolism |
| title | The Vagogastrone Mechanism in Man |
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