Induced cell proliferation and the initiation of skin tumour formation in mice by ultraviolet light
A single short exposure of the skin of mice to ultraviolet light did not produce any tumours, but a significant number of tumours developed when the exposure was followed by repeated applications of croton oil. Ultraviolet radiation therefore behaves as an initiating agent, resembling this action of...
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| Veröffentlicht in: | Pathology 1970-01, Vol.2 (4), p.269-275 |
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| creator | Pound, A.W. |
| description | A single short exposure of the skin of mice to ultraviolet light did not produce any tumours, but a significant number of tumours developed when the exposure was followed by repeated applications of croton oil. Ultraviolet radiation therefore behaves as an initiating agent, resembling this action of some other carcinogens for the skin of mice.
Treatment of the skin of the mice with acetic acid, xylene or croton oil 20 hours before irradiation increased the number of tumours. It is considered that cells induced to proliferate are more susceptible to the carcinogenic effect of ultraviolet radiation than their normal counterparts. |
| doi_str_mv | 10.3109/00313027009077141 |
| format | Article |
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Treatment of the skin of the mice with acetic acid, xylene or croton oil 20 hours before irradiation increased the number of tumours. It is considered that cells induced to proliferate are more susceptible to the carcinogenic effect of ultraviolet radiation than their normal counterparts.</description><identifier>ISSN: 0031-3025</identifier><identifier>EISSN: 1465-3931</identifier><identifier>DOI: 10.3109/00313027009077141</identifier><identifier>PMID: 5520772</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Acetates - pharmacology ; ACETIC ACID ; ACETIC ACID/radiosensitizing effects on tumorigenesis in skin of mice, uv ; Animals ; CARCINOGENS ; CROTON OIL ; Croton Oil - pharmacology ; CROTON OIL/radiosensitizing effects on tumorigenesis in skin of mice, uv ; DISEASES, NEOPLASTIC/tumors, radioinduced, in skin of mice, sensitizing effects of acetic acid, croton oil, and xylene on uv ; IRRADIATION ; Male ; MICE ; N28510 -Life Sciences-Medicine-Protective Substances ; N28620 -Life Sciences-Radiation Effects on Animals-Vertebrates ; Neoplasms, Experimental ; Neoplasms, Radiation-Induced ; RADIATION EFFECTS ; SKIN ; Skin - drug effects ; Skin - radiation effects ; Skin Neoplasms ; SKIN/radioinduced tumorigenesis in mouse, sensitizing effects of acetic acid, croton oil, and xylene on uv ; Time Factors ; TUMORS ; ULTRAVIOLET RADIATION ; ULTRAVIOLET RADIATION/effects on skin of mice, sensitizing effects of acetic acid, croton oil, and xylene on tumorigenic ; Ultraviolet Rays ; XYLENE ; XYLENE/radiosensitizing effects on tumorigenesis in skin of mice, uv ; Xylenes - pharmacology</subject><ispartof>Pathology, 1970-01, Vol.2 (4), p.269-275</ispartof><rights>1970 Royal College of Pathologists of Australasia</rights><rights>1970 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1970</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-97dab55379cb531f8b5ac1af0cf2e4633d437d5d6fe2f027ecd9137bef822da3</citedby><cites>FETCH-LOGICAL-c427t-97dab55379cb531f8b5ac1af0cf2e4633d437d5d6fe2f027ecd9137bef822da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00313027009077141$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00313027009077141$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,885,27924,27925,61221,61402</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5520772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4006901$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Pound, A.W.</creatorcontrib><creatorcontrib>Univ. of Queensland, Brisbane</creatorcontrib><title>Induced cell proliferation and the initiation of skin tumour formation in mice by ultraviolet light</title><title>Pathology</title><addtitle>Pathology</addtitle><description>A single short exposure of the skin of mice to ultraviolet light did not produce any tumours, but a significant number of tumours developed when the exposure was followed by repeated applications of croton oil. Ultraviolet radiation therefore behaves as an initiating agent, resembling this action of some other carcinogens for the skin of mice.
Treatment of the skin of the mice with acetic acid, xylene or croton oil 20 hours before irradiation increased the number of tumours. It is considered that cells induced to proliferate are more susceptible to the carcinogenic effect of ultraviolet radiation than their normal counterparts.</description><subject>Acetates - pharmacology</subject><subject>ACETIC ACID</subject><subject>ACETIC ACID/radiosensitizing effects on tumorigenesis in skin of mice, uv</subject><subject>Animals</subject><subject>CARCINOGENS</subject><subject>CROTON OIL</subject><subject>Croton Oil - pharmacology</subject><subject>CROTON OIL/radiosensitizing effects on tumorigenesis in skin of mice, uv</subject><subject>DISEASES, NEOPLASTIC/tumors, radioinduced, in skin of mice, sensitizing effects of acetic acid, croton oil, and xylene on uv</subject><subject>IRRADIATION</subject><subject>Male</subject><subject>MICE</subject><subject>N28510 -Life Sciences-Medicine-Protective Substances</subject><subject>N28620 -Life Sciences-Radiation Effects on Animals-Vertebrates</subject><subject>Neoplasms, Experimental</subject><subject>Neoplasms, Radiation-Induced</subject><subject>RADIATION EFFECTS</subject><subject>SKIN</subject><subject>Skin - drug effects</subject><subject>Skin - radiation effects</subject><subject>Skin Neoplasms</subject><subject>SKIN/radioinduced tumorigenesis in mouse, sensitizing effects of acetic acid, croton oil, and xylene on uv</subject><subject>Time Factors</subject><subject>TUMORS</subject><subject>ULTRAVIOLET RADIATION</subject><subject>ULTRAVIOLET RADIATION/effects on skin of mice, sensitizing effects of acetic acid, croton oil, and xylene on tumorigenic</subject><subject>Ultraviolet Rays</subject><subject>XYLENE</subject><subject>XYLENE/radiosensitizing effects on tumorigenesis in skin of mice, uv</subject><subject>Xylenes - pharmacology</subject><issn>0031-3025</issn><issn>1465-3931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9LwzAUx4Moc07_AA9C8F5NmmZt8STDH4OBl91LmrzYzDYZaTrYf29qhxfBU-B93-fx3icI3VLywCgpHwlhlJE0J6QkeU4zeobmNFvyhJWMnqP5mCexgV-iq77fEUKyoihmaMZ5GoF0juTaqkGCwhLaFu-9a40GL4JxFgurcGgAG2uCmUpO4_7LWByGzg0ea-e7KYi1zkjA9REPbfDiYFwLAbfmswnX6EKLtoeb07tA29eX7eo92Xy8rVfPm0RmaR6SMlei5pzlpaw5o7qouZBUaCJ1CtmSMZWxXHG11JDqeDRIVVKW16CLNFWCLdD9NNb1wVS9NAFkI521IEOVEbIsCY1NdGqS3vW9B13tvemEP1aUVKPT6o_TyNxNzH6oO1C_xElizJ-m3NgfIQ2INjRSeKh20ZKNN_87_URDVHMw4MfVwcY_MX7cXDnzD_0NdgeXow</recordid><startdate>19700101</startdate><enddate>19700101</enddate><creator>Pound, A.W.</creator><general>Elsevier B.V</general><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19700101</creationdate><title>Induced cell proliferation and the initiation of skin tumour formation in mice by ultraviolet light</title><author>Pound, A.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-97dab55379cb531f8b5ac1af0cf2e4633d437d5d6fe2f027ecd9137bef822da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Acetates - pharmacology</topic><topic>ACETIC ACID</topic><topic>ACETIC ACID/radiosensitizing effects on tumorigenesis in skin of mice, uv</topic><topic>Animals</topic><topic>CARCINOGENS</topic><topic>CROTON OIL</topic><topic>Croton Oil - pharmacology</topic><topic>CROTON OIL/radiosensitizing effects on tumorigenesis in skin of mice, uv</topic><topic>DISEASES, NEOPLASTIC/tumors, radioinduced, in skin of mice, sensitizing effects of acetic acid, croton oil, and xylene on uv</topic><topic>IRRADIATION</topic><topic>Male</topic><topic>MICE</topic><topic>N28510 -Life Sciences-Medicine-Protective Substances</topic><topic>N28620 -Life Sciences-Radiation Effects on Animals-Vertebrates</topic><topic>Neoplasms, Experimental</topic><topic>Neoplasms, Radiation-Induced</topic><topic>RADIATION EFFECTS</topic><topic>SKIN</topic><topic>Skin - drug effects</topic><topic>Skin - radiation effects</topic><topic>Skin Neoplasms</topic><topic>SKIN/radioinduced tumorigenesis in mouse, sensitizing effects of acetic acid, croton oil, and xylene on uv</topic><topic>Time Factors</topic><topic>TUMORS</topic><topic>ULTRAVIOLET RADIATION</topic><topic>ULTRAVIOLET RADIATION/effects on skin of mice, sensitizing effects of acetic acid, croton oil, and xylene on tumorigenic</topic><topic>Ultraviolet Rays</topic><topic>XYLENE</topic><topic>XYLENE/radiosensitizing effects on tumorigenesis in skin of mice, uv</topic><topic>Xylenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pound, A.W.</creatorcontrib><creatorcontrib>Univ. of Queensland, Brisbane</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pound, A.W.</au><aucorp>Univ. of Queensland, Brisbane</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induced cell proliferation and the initiation of skin tumour formation in mice by ultraviolet light</atitle><jtitle>Pathology</jtitle><addtitle>Pathology</addtitle><date>1970-01-01</date><risdate>1970</risdate><volume>2</volume><issue>4</issue><spage>269</spage><epage>275</epage><pages>269-275</pages><issn>0031-3025</issn><eissn>1465-3931</eissn><abstract>A single short exposure of the skin of mice to ultraviolet light did not produce any tumours, but a significant number of tumours developed when the exposure was followed by repeated applications of croton oil. Ultraviolet radiation therefore behaves as an initiating agent, resembling this action of some other carcinogens for the skin of mice.
Treatment of the skin of the mice with acetic acid, xylene or croton oil 20 hours before irradiation increased the number of tumours. It is considered that cells induced to proliferate are more susceptible to the carcinogenic effect of ultraviolet radiation than their normal counterparts.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>5520772</pmid><doi>10.3109/00313027009077141</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3025 |
| ispartof | Pathology, 1970-01, Vol.2 (4), p.269-275 |
| issn | 0031-3025 1465-3931 |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_00313027009077141 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Alma/SFX Local Collection |
| subjects | Acetates - pharmacology ACETIC ACID ACETIC ACID/radiosensitizing effects on tumorigenesis in skin of mice, uv Animals CARCINOGENS CROTON OIL Croton Oil - pharmacology CROTON OIL/radiosensitizing effects on tumorigenesis in skin of mice, uv DISEASES, NEOPLASTIC/tumors, radioinduced, in skin of mice, sensitizing effects of acetic acid, croton oil, and xylene on uv IRRADIATION Male MICE N28510 -Life Sciences-Medicine-Protective Substances N28620 -Life Sciences-Radiation Effects on Animals-Vertebrates Neoplasms, Experimental Neoplasms, Radiation-Induced RADIATION EFFECTS SKIN Skin - drug effects Skin - radiation effects Skin Neoplasms SKIN/radioinduced tumorigenesis in mouse, sensitizing effects of acetic acid, croton oil, and xylene on uv Time Factors TUMORS ULTRAVIOLET RADIATION ULTRAVIOLET RADIATION/effects on skin of mice, sensitizing effects of acetic acid, croton oil, and xylene on tumorigenic Ultraviolet Rays XYLENE XYLENE/radiosensitizing effects on tumorigenesis in skin of mice, uv Xylenes - pharmacology |
| title | Induced cell proliferation and the initiation of skin tumour formation in mice by ultraviolet light |
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