Peritoneal fluid 6-keto-prostaglandin FLα, thromboxane B2 in endometriosis and unexplained infertility
To study peritoneal fluid (PF) prostaglandin (PG) in infertile women, 6-keto-PGFla (a breakdown product of prostacyclin) and thromboxane B2 (T × B2) (a metabolite of T × A2) were assayed with radio-immunoassays from PF samples collected at laparascopy from patients with endo-metriosis (n = 29), unex...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 1984, Vol.63 (S123), p.19-21 |
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| container_issue | S123 |
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| container_title | Acta obstetricia et gynecologica Scandinavica |
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| creator | Koskimies, Aarne I. Tenhunen, Anssi Mikorkala, Olavi |
| description | To study peritoneal fluid (PF) prostaglandin (PG) in infertile women, 6-keto-PGFla (a breakdown product of prostacyclin) and thromboxane B2 (T × B2) (a metabolite of T × A2) were assayed with radio-immunoassays from PF samples collected at laparascopy from patients with endo-metriosis (n = 29), unexplained infertility (n = 13) and from women with normal pelvic organs (n = 25). The concentrations of 6-keto-PGFla and T×82 in PF were increased (p |
| doi_str_mv | 10.3109/00016348409156975 |
| format | Article |
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The concentrations of 6-keto-PGFla and T×82 in PF were increased (p<0.05) in endometriosis and unexplained infertility, as compared with the corresponding levels in the controls. In patients with endometriosis, both 6-keto-PGFla and T × B2 increases were related to the severity of the disease. There was no relationship between 6-keto-PGF1α × B2 in PF, and day of menstrual cycle. It is suggested that endometriotic tissue and peritoneal macrophages may contribute to these prostanoids in PF. The smooth muscle activities of PF prostacyclin and T × A2 may be involved in infertility by interfering with tuba1 function.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.3109/00016348409156975</identifier><language>eng</language><publisher>Oxford, UK: Informa UK Ltd</publisher><subject>endometriosis ; infertility ; Prostaglandins</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 1984, Vol.63 (S123), p.19-21</ispartof><rights>1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1984</rights><rights>1984 Acta Obstet Gynecol Scand</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2956-bfe939f2ff2b452409c6bdef2f40637cc77ad40ca07aac1590211b700887c4b53</citedby><cites>FETCH-LOGICAL-c2956-bfe939f2ff2b452409c6bdef2f40637cc77ad40ca07aac1590211b700887c4b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.3109%2F00016348409156975$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.3109%2F00016348409156975$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,4010,27904,27905,27906,45555,45556</link.rule.ids></links><search><creatorcontrib>Koskimies, Aarne I.</creatorcontrib><creatorcontrib>Tenhunen, Anssi</creatorcontrib><creatorcontrib>Mikorkala, Olavi</creatorcontrib><title>Peritoneal fluid 6-keto-prostaglandin FLα, thromboxane B2 in endometriosis and unexplained infertility</title><title>Acta obstetricia et gynecologica Scandinavica</title><description>To study peritoneal fluid (PF) prostaglandin (PG) in infertile women, 6-keto-PGFla (a breakdown product of prostacyclin) and thromboxane B2 (T × B2) (a metabolite of T × A2) were assayed with radio-immunoassays from PF samples collected at laparascopy from patients with endo-metriosis (n = 29), unexplained infertility (n = 13) and from women with normal pelvic organs (n = 25). The concentrations of 6-keto-PGFla and T×82 in PF were increased (p<0.05) in endometriosis and unexplained infertility, as compared with the corresponding levels in the controls. In patients with endometriosis, both 6-keto-PGFla and T × B2 increases were related to the severity of the disease. There was no relationship between 6-keto-PGF1α × B2 in PF, and day of menstrual cycle. It is suggested that endometriotic tissue and peritoneal macrophages may contribute to these prostanoids in PF. The smooth muscle activities of PF prostacyclin and T × A2 may be involved in infertility by interfering with tuba1 function.</description><subject>endometriosis</subject><subject>infertility</subject><subject>Prostaglandins</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNqFkF9KAzEQh4MoWKsH8G0P4Opk_yQbfNJqq1BUUFF8CdlsYmO3Scmm2B7Li3gmUyq-CPoUZub7wswPoUMMxzkGdgIAmORFVQDDJWG03EI9TABSKHC2jXrreRoBtov2uu4tVhktqh56vVPeBGeVaBPdLkyTkHSqgkvn3nVBvLbCNsYmw_Hnx1ESJt7NarcUViXnWRL7yjZupoI3rjNdEtlkYdVy3gpjVRMBrXwwrQmrfbSjRdupg--3jx6Hlw-Dq3R8O7oenI1TmbGSpLVWLGc60zqrizKL10hSNyo2CiA5lZJS0RQgBVAhJC4ZZBjXFKCqqCzqMu8jvPlXxv07rzSfezMTfsUx8HVS_FdS0SEb5920avW_wM9uRwQqEsV0I5ouqOWPKPyUE5pH8OlmxB9e7i_Y88uI08iffvNWOz8Tk5h6mEjhFX9zC29jMH-s-QVWXo6w</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Koskimies, Aarne I.</creator><creator>Tenhunen, Anssi</creator><creator>Mikorkala, Olavi</creator><general>Informa UK Ltd</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1984</creationdate><title>Peritoneal fluid 6-keto-prostaglandin FLα, thromboxane B2 in endometriosis and unexplained infertility</title><author>Koskimies, Aarne I. ; Tenhunen, Anssi ; Mikorkala, Olavi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2956-bfe939f2ff2b452409c6bdef2f40637cc77ad40ca07aac1590211b700887c4b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>endometriosis</topic><topic>infertility</topic><topic>Prostaglandins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koskimies, Aarne I.</creatorcontrib><creatorcontrib>Tenhunen, Anssi</creatorcontrib><creatorcontrib>Mikorkala, Olavi</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koskimies, Aarne I.</au><au>Tenhunen, Anssi</au><au>Mikorkala, Olavi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peritoneal fluid 6-keto-prostaglandin FLα, thromboxane B2 in endometriosis and unexplained infertility</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><date>1984</date><risdate>1984</risdate><volume>63</volume><issue>S123</issue><spage>19</spage><epage>21</epage><pages>19-21</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><abstract>To study peritoneal fluid (PF) prostaglandin (PG) in infertile women, 6-keto-PGFla (a breakdown product of prostacyclin) and thromboxane B2 (T × B2) (a metabolite of T × A2) were assayed with radio-immunoassays from PF samples collected at laparascopy from patients with endo-metriosis (n = 29), unexplained infertility (n = 13) and from women with normal pelvic organs (n = 25). The concentrations of 6-keto-PGFla and T×82 in PF were increased (p<0.05) in endometriosis and unexplained infertility, as compared with the corresponding levels in the controls. In patients with endometriosis, both 6-keto-PGFla and T × B2 increases were related to the severity of the disease. There was no relationship between 6-keto-PGF1α × B2 in PF, and day of menstrual cycle. It is suggested that endometriotic tissue and peritoneal macrophages may contribute to these prostanoids in PF. The smooth muscle activities of PF prostacyclin and T × A2 may be involved in infertility by interfering with tuba1 function.</abstract><cop>Oxford, UK</cop><pub>Informa UK Ltd</pub><doi>10.3109/00016348409156975</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0001-6349 |
| ispartof | Acta obstetricia et gynecologica Scandinavica, 1984, Vol.63 (S123), p.19-21 |
| issn | 0001-6349 1600-0412 |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_00016348409156975 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | endometriosis infertility Prostaglandins |
| title | Peritoneal fluid 6-keto-prostaglandin FLα, thromboxane B2 in endometriosis and unexplained infertility |
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