Effect of Acetylsalicylic Acid, Paracetamol and Placebo on Pain and Blood Loss in Dysmenorrheic Women
The analgesic effect of paracetamol, acetyl-salicylic acid, and placebo on dysmenorrhea were compared in a double-blind cross-over study of 30 women. There was a moderate placebo effect, but no significant difference was found between the three treatments. Blood loss was also measured and it did not...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 1979, Vol.58 (S87), p.81-85 |
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| container_end_page | 85 |
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| container_issue | S87 |
| container_start_page | 81 |
| container_title | Acta obstetricia et gynecologica Scandinavica |
| container_volume | 58 |
| creator | Janbu, Torun Løkken, Per Nesheim, Britt-Ingjerd |
| description | The analgesic effect of paracetamol, acetyl-salicylic acid, and placebo on dysmenorrhea were compared in a double-blind cross-over study of 30 women. There was a moderate placebo effect, but no significant difference was found between the three treatments. Blood loss was also measured and it did not vary, with the type of drug ingested. It is concluded that paracetamol and acetylsalicylic acid in the doses used (0.5 g x 4 for 3 days) were not effective against heavy dysmenorrhea, and that none of the drugs influenced the amount of blood lost. |
| doi_str_mv | 10.3109/00016347909157796 |
| format | Article |
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There was a moderate placebo effect, but no significant difference was found between the three treatments. Blood loss was also measured and it did not vary, with the type of drug ingested. It is concluded that paracetamol and acetylsalicylic acid in the doses used (0.5 g x 4 for 3 days) were not effective against heavy dysmenorrhea, and that none of the drugs influenced the amount of blood lost.</description><identifier>ISSN: 0001-6349</identifier><identifier>ISSN: 0300-8835</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.3109/00016347909157796</identifier><identifier>PMID: 380253</identifier><language>eng</language><publisher>Oxford, UK: Informa UK Ltd</publisher><subject>Acetaminophen - adverse effects ; Acetaminophen - therapeutic use ; Adult ; Aspirin - adverse effects ; Aspirin - therapeutic use ; Blood Specimen Collection ; Blood Volume ; Clinical Trials as Topic ; Double-Blind Method ; Drug Evaluation ; Dysmenorrhea - drug therapy ; Female ; Humans ; Menstruation ; Placebos</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 1979, Vol.58 (S87), p.81-85</ispartof><rights>1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1979</rights><rights>1979 Acta Obstet Gynecol Scand</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4017-c07250891af3bfda78f9f0cac8bada0abcf7b07a9d1ba98d815476f8655f13773</citedby><cites>FETCH-LOGICAL-c4017-c07250891af3bfda78f9f0cac8bada0abcf7b07a9d1ba98d815476f8655f13773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.3109%2F00016347909157796$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.3109%2F00016347909157796$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,4026,27930,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/380253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janbu, Torun</creatorcontrib><creatorcontrib>Løkken, Per</creatorcontrib><creatorcontrib>Nesheim, Britt-Ingjerd</creatorcontrib><title>Effect of Acetylsalicylic Acid, Paracetamol and Placebo on Pain and Blood Loss in Dysmenorrheic Women</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand Suppl</addtitle><description>The analgesic effect of paracetamol, acetyl-salicylic acid, and placebo on dysmenorrhea were compared in a double-blind cross-over study of 30 women. There was a moderate placebo effect, but no significant difference was found between the three treatments. Blood loss was also measured and it did not vary, with the type of drug ingested. It is concluded that paracetamol and acetylsalicylic acid in the doses used (0.5 g x 4 for 3 days) were not effective against heavy dysmenorrhea, and that none of the drugs influenced the amount of blood lost.</description><subject>Acetaminophen - adverse effects</subject><subject>Acetaminophen - therapeutic use</subject><subject>Adult</subject><subject>Aspirin - adverse effects</subject><subject>Aspirin - therapeutic use</subject><subject>Blood Specimen Collection</subject><subject>Blood Volume</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Drug Evaluation</subject><subject>Dysmenorrhea - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Menstruation</subject><subject>Placebos</subject><issn>0001-6349</issn><issn>0300-8835</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUF1P2zAUtaYxVrr9gEl7yA9Y4DqOY1t76goUpA76wNRH68ax1UASV04ryL_HJRUvk7YHyzr3fOjeQ8g3CueMgroAAFqwXChQlAuhig9kQguAFHKafSSTA59GgfpMzvr-MaJM5PKUfGISMs4mxF45Z80u8S6ZGbsbmh6b2gzxRVxXP5IVBowEtr5JsKuSVRNh6RPfRaru3ma_Gu-rZOn7PomTy6FvbedD2NiYsvYRfCEnDpvefj3-U_Ln-uphfpMu7xe389kyNTlQkRoQGQepKDpWugqFdMqBQSNLrBCwNE6UIFBVtEQlK0l5LgonC84dZUKwKaFjrglxmWCd3oa6xTBoCvpQmP6rsOj5Pnq2-7K11btjbCjSxUg_140d_p-nZ_cLnrHDLulorPudfXk3YnjShWCC6_XdQmeZVDwrVvp31P886jvnQ4sbi81uYzBY_ej3oYu9_eOKV5UrlmM</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Janbu, Torun</creator><creator>Løkken, Per</creator><creator>Nesheim, Britt-Ingjerd</creator><general>Informa UK Ltd</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1979</creationdate><title>Effect of Acetylsalicylic Acid, Paracetamol and Placebo on Pain and Blood Loss in Dysmenorrheic Women</title><author>Janbu, Torun ; Løkken, Per ; Nesheim, Britt-Ingjerd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4017-c07250891af3bfda78f9f0cac8bada0abcf7b07a9d1ba98d815476f8655f13773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Acetaminophen - adverse effects</topic><topic>Acetaminophen - therapeutic use</topic><topic>Adult</topic><topic>Aspirin - adverse effects</topic><topic>Aspirin - therapeutic use</topic><topic>Blood Specimen Collection</topic><topic>Blood Volume</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Drug Evaluation</topic><topic>Dysmenorrhea - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Menstruation</topic><topic>Placebos</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janbu, Torun</creatorcontrib><creatorcontrib>Løkken, Per</creatorcontrib><creatorcontrib>Nesheim, Britt-Ingjerd</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janbu, Torun</au><au>Løkken, Per</au><au>Nesheim, Britt-Ingjerd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Acetylsalicylic Acid, Paracetamol and Placebo on Pain and Blood Loss in Dysmenorrheic Women</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand Suppl</addtitle><date>1979</date><risdate>1979</risdate><volume>58</volume><issue>S87</issue><spage>81</spage><epage>85</epage><pages>81-85</pages><issn>0001-6349</issn><issn>0300-8835</issn><eissn>1600-0412</eissn><abstract>The analgesic effect of paracetamol, acetyl-salicylic acid, and placebo on dysmenorrhea were compared in a double-blind cross-over study of 30 women. There was a moderate placebo effect, but no significant difference was found between the three treatments. Blood loss was also measured and it did not vary, with the type of drug ingested. It is concluded that paracetamol and acetylsalicylic acid in the doses used (0.5 g x 4 for 3 days) were not effective against heavy dysmenorrhea, and that none of the drugs influenced the amount of blood lost.</abstract><cop>Oxford, UK</cop><pub>Informa UK Ltd</pub><pmid>380253</pmid><doi>10.3109/00016347909157796</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6349 |
| ispartof | Acta obstetricia et gynecologica Scandinavica, 1979, Vol.58 (S87), p.81-85 |
| issn | 0001-6349 0300-8835 1600-0412 |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_00016347909157796 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Acetaminophen - adverse effects Acetaminophen - therapeutic use Adult Aspirin - adverse effects Aspirin - therapeutic use Blood Specimen Collection Blood Volume Clinical Trials as Topic Double-Blind Method Drug Evaluation Dysmenorrhea - drug therapy Female Humans Menstruation Placebos |
| title | Effect of Acetylsalicylic Acid, Paracetamol and Placebo on Pain and Blood Loss in Dysmenorrheic Women |
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