The effect of regularly performed moderate-intensity exercise program on thiol/disulfide homeostasis, and ischemia-modified albumin

The effect of regularly performed moderate-intensity exercise program on thiol/disulfide homeostasis, and ischemia-modified albumin

Aim: Thiol/disulfide homeostasis is an indicator of oxidative stress and antioxidant capacity. Ischemia-modified albumin (IMA) is an important marker for both oxidative stress and ischemia. We aimed to evaluate the possible effects of regularly performed moderate-intensity exercise on thiol/disulfid...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta medica Alanya 2022-08, Vol.6 (2), p.120-125
Hauptverfasser: PALA, Mukaddes, ALTAN, Mehmet, HANİKOGLU, Ferahat, NESELİOGLU, Salim, EREL, Özcan, METİN, Gökhan
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 125
container_issue 2
container_start_page 120
container_title Acta medica Alanya
container_volume 6
creator PALA, Mukaddes
ALTAN, Mehmet
HANİKOGLU, Ferahat
NESELİOGLU, Salim
EREL, Özcan
METİN, Gökhan
description Aim: Thiol/disulfide homeostasis is an indicator of oxidative stress and antioxidant capacity. Ischemia-modified albumin (IMA) is an important marker for both oxidative stress and ischemia. We aimed to evaluate the possible effects of regularly performed moderate-intensity exercise on thiol/disulfide homeostasis, and IMA levels.Methods: Sprague Dawley rats were used. The study was composed of an Exercise group (EG, n=9) and Control group (CG, n=6). A 10-weeks swimming exercise was performed. Thiol/disulfide homeostasis measurement method was used in this study. IMA levels were measured by a cobalt-albumin binding method.Results: In the EG, total thiol levels were significantly higher compared to the CG (p
doi_str_mv 10.30565/medalanya.1055424
format Article
fullrecord <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_30565_medalanya_1055424</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_30565_medalanya_1055424</sourcerecordid><originalsourceid>FETCH-crossref_primary_10_30565_medalanya_10554243</originalsourceid><addsrcrecordid>eNqdj01OwzAQRi0EEhX0AqzmAKR1ftyWNQJxgO6jIRk3g-w4mnElsubiRKhCrFl9b_M96RnzUNpNbd3ObSP1GHCccVNa55qquTKryh32ha3Lp-s_fGvWqh_W2uqwb9yuWpmv40BA3lOXIXkQOp0DSphhIvFJFjPE1JNgpoLHTKNynoE-STpWgknSSTBCGiEPnMK2Zz0Hzz3BkCIlzaisj4BjD6zdQJGxWITseTFjeD9HHu_NjcegtL7snaleX47Pb0UnSVXIt5NwRJnb0rY_xe1vcXsprv91-gZE3WZi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The effect of regularly performed moderate-intensity exercise program on thiol/disulfide homeostasis, and ischemia-modified albumin</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>PALA, Mukaddes ; ALTAN, Mehmet ; HANİKOGLU, Ferahat ; NESELİOGLU, Salim ; EREL, Özcan ; METİN, Gökhan</creator><creatorcontrib>PALA, Mukaddes ; ALTAN, Mehmet ; HANİKOGLU, Ferahat ; NESELİOGLU, Salim ; EREL, Özcan ; METİN, Gökhan</creatorcontrib><description>Aim: Thiol/disulfide homeostasis is an indicator of oxidative stress and antioxidant capacity. Ischemia-modified albumin (IMA) is an important marker for both oxidative stress and ischemia. We aimed to evaluate the possible effects of regularly performed moderate-intensity exercise on thiol/disulfide homeostasis, and IMA levels.Methods: Sprague Dawley rats were used. The study was composed of an Exercise group (EG, n=9) and Control group (CG, n=6). A 10-weeks swimming exercise was performed. Thiol/disulfide homeostasis measurement method was used in this study. IMA levels were measured by a cobalt-albumin binding method.Results: In the EG, total thiol levels were significantly higher compared to the CG (p&lt;0.01). The disulfide/total thiol ratio was lower in the EG compared to the CG (p&lt;0.01). We observed that there was a slight increase in IMA levels in EG (p=0.18). This increase was not statistically significant.Conclusion: Regularly performed moderate-intensity exercise has increased native and total thiol levels. Increase of thiol levels can prevent oxidative stress. Regularly performed moderate-intensity exercise programs appear to provide favourable effects on oxidative stress.  Amaç: Tiyol/disülfid homeostazı, oksidatif stresin ve antioksidan kapasitenin bir göstergesidir. İskemi-modifiye albümin (İMA), hem oksidatif stres hem de iskemi için önemli bir belirteçtir. Düzenli olarak uygulanan orta şiddetteki egzersizin tiyol/disülfid homeostazı ve IMA seviyeleri üzerine olası etkilerini değerlendirmeyi amaçladık.Yöntemler: Sprague-Dawley sıçanlar kullanıldı. Çalışma, Egzersiz grubu (EG, n=9) ve Kontrol grubundan (KG, n=6) oluşturuldu. 10 haftalık bir yüzme egzersizi yaptırıldı. Bu çalışmada tiyol/disülfid homeostazı ölçüm yöntemi kullanıldı. İMA seviyeleri, bir kobalt-albümin bağlama yöntemiyle ölçüldü.Bulgular: EG'de, total tiyol seviyeleri KG ile karşılaştırıldığında anlamlı derecede daha yüksekti (p&lt;0.01). Disülfid/total tiyol oranı EG’da KG ile karşılaştırıldığında daha düşüktü (p&lt;0.01). EG'da IMA seviyelerinde hafif bir artış olduğunu gözlemledik (p=0,18). Bu artış istatistiksel olarak anlamlı değildi.Sonuç: Düzenli olarak uygulanan orta şiddetteki egzersiz, nativ ve total tiyol seviyelerini artırdı. Tiyol seviyelerinin artması oksidatif stresi önleyebilir. Düzenli olarak uygulanan orta şiddetteki egzersiz programlarının oksidatif stres üzerinde olumlu etkiler sağladığı görülmektedir.</description><identifier>ISSN: 2587-0319</identifier><identifier>EISSN: 2587-0319</identifier><identifier>DOI: 10.30565/medalanya.1055424</identifier><language>eng</language><ispartof>Acta medica Alanya, 2022-08, Vol.6 (2), p.120-125</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-crossref_primary_10_30565_medalanya_10554243</cites><orcidid>0000-0002-0974-5717 ; 0000-0002-2996-3236 ; 0000-0002-6979-9469 ; 0000-0002-3275-1234 ; 0000-0002-0770-2692 ; 0000-0002-0610-0526</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>PALA, Mukaddes</creatorcontrib><creatorcontrib>ALTAN, Mehmet</creatorcontrib><creatorcontrib>HANİKOGLU, Ferahat</creatorcontrib><creatorcontrib>NESELİOGLU, Salim</creatorcontrib><creatorcontrib>EREL, Özcan</creatorcontrib><creatorcontrib>METİN, Gökhan</creatorcontrib><title>The effect of regularly performed moderate-intensity exercise program on thiol/disulfide homeostasis, and ischemia-modified albumin</title><title>Acta medica Alanya</title><description>Aim: Thiol/disulfide homeostasis is an indicator of oxidative stress and antioxidant capacity. Ischemia-modified albumin (IMA) is an important marker for both oxidative stress and ischemia. We aimed to evaluate the possible effects of regularly performed moderate-intensity exercise on thiol/disulfide homeostasis, and IMA levels.Methods: Sprague Dawley rats were used. The study was composed of an Exercise group (EG, n=9) and Control group (CG, n=6). A 10-weeks swimming exercise was performed. Thiol/disulfide homeostasis measurement method was used in this study. IMA levels were measured by a cobalt-albumin binding method.Results: In the EG, total thiol levels were significantly higher compared to the CG (p&lt;0.01). The disulfide/total thiol ratio was lower in the EG compared to the CG (p&lt;0.01). We observed that there was a slight increase in IMA levels in EG (p=0.18). This increase was not statistically significant.Conclusion: Regularly performed moderate-intensity exercise has increased native and total thiol levels. Increase of thiol levels can prevent oxidative stress. Regularly performed moderate-intensity exercise programs appear to provide favourable effects on oxidative stress.  Amaç: Tiyol/disülfid homeostazı, oksidatif stresin ve antioksidan kapasitenin bir göstergesidir. İskemi-modifiye albümin (İMA), hem oksidatif stres hem de iskemi için önemli bir belirteçtir. Düzenli olarak uygulanan orta şiddetteki egzersizin tiyol/disülfid homeostazı ve IMA seviyeleri üzerine olası etkilerini değerlendirmeyi amaçladık.Yöntemler: Sprague-Dawley sıçanlar kullanıldı. Çalışma, Egzersiz grubu (EG, n=9) ve Kontrol grubundan (KG, n=6) oluşturuldu. 10 haftalık bir yüzme egzersizi yaptırıldı. Bu çalışmada tiyol/disülfid homeostazı ölçüm yöntemi kullanıldı. İMA seviyeleri, bir kobalt-albümin bağlama yöntemiyle ölçüldü.Bulgular: EG'de, total tiyol seviyeleri KG ile karşılaştırıldığında anlamlı derecede daha yüksekti (p&lt;0.01). Disülfid/total tiyol oranı EG’da KG ile karşılaştırıldığında daha düşüktü (p&lt;0.01). EG'da IMA seviyelerinde hafif bir artış olduğunu gözlemledik (p=0,18). Bu artış istatistiksel olarak anlamlı değildi.Sonuç: Düzenli olarak uygulanan orta şiddetteki egzersiz, nativ ve total tiyol seviyelerini artırdı. Tiyol seviyelerinin artması oksidatif stresi önleyebilir. Düzenli olarak uygulanan orta şiddetteki egzersiz programlarının oksidatif stres üzerinde olumlu etkiler sağladığı görülmektedir.</description><issn>2587-0319</issn><issn>2587-0319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqdj01OwzAQRi0EEhX0AqzmAKR1ftyWNQJxgO6jIRk3g-w4mnElsubiRKhCrFl9b_M96RnzUNpNbd3ObSP1GHCccVNa55qquTKryh32ha3Lp-s_fGvWqh_W2uqwb9yuWpmv40BA3lOXIXkQOp0DSphhIvFJFjPE1JNgpoLHTKNynoE-STpWgknSSTBCGiEPnMK2Zz0Hzz3BkCIlzaisj4BjD6zdQJGxWITseTFjeD9HHu_NjcegtL7snaleX47Pb0UnSVXIt5NwRJnb0rY_xe1vcXsprv91-gZE3WZi</recordid><startdate>20220820</startdate><enddate>20220820</enddate><creator>PALA, Mukaddes</creator><creator>ALTAN, Mehmet</creator><creator>HANİKOGLU, Ferahat</creator><creator>NESELİOGLU, Salim</creator><creator>EREL, Özcan</creator><creator>METİN, Gökhan</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-0974-5717</orcidid><orcidid>https://orcid.org/0000-0002-2996-3236</orcidid><orcidid>https://orcid.org/0000-0002-6979-9469</orcidid><orcidid>https://orcid.org/0000-0002-3275-1234</orcidid><orcidid>https://orcid.org/0000-0002-0770-2692</orcidid><orcidid>https://orcid.org/0000-0002-0610-0526</orcidid></search><sort><creationdate>20220820</creationdate><title>The effect of regularly performed moderate-intensity exercise program on thiol/disulfide homeostasis, and ischemia-modified albumin</title><author>PALA, Mukaddes ; ALTAN, Mehmet ; HANİKOGLU, Ferahat ; NESELİOGLU, Salim ; EREL, Özcan ; METİN, Gökhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-crossref_primary_10_30565_medalanya_10554243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PALA, Mukaddes</creatorcontrib><creatorcontrib>ALTAN, Mehmet</creatorcontrib><creatorcontrib>HANİKOGLU, Ferahat</creatorcontrib><creatorcontrib>NESELİOGLU, Salim</creatorcontrib><creatorcontrib>EREL, Özcan</creatorcontrib><creatorcontrib>METİN, Gökhan</creatorcontrib><collection>CrossRef</collection><jtitle>Acta medica Alanya</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PALA, Mukaddes</au><au>ALTAN, Mehmet</au><au>HANİKOGLU, Ferahat</au><au>NESELİOGLU, Salim</au><au>EREL, Özcan</au><au>METİN, Gökhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of regularly performed moderate-intensity exercise program on thiol/disulfide homeostasis, and ischemia-modified albumin</atitle><jtitle>Acta medica Alanya</jtitle><date>2022-08-20</date><risdate>2022</risdate><volume>6</volume><issue>2</issue><spage>120</spage><epage>125</epage><pages>120-125</pages><issn>2587-0319</issn><eissn>2587-0319</eissn><abstract>Aim: Thiol/disulfide homeostasis is an indicator of oxidative stress and antioxidant capacity. Ischemia-modified albumin (IMA) is an important marker for both oxidative stress and ischemia. We aimed to evaluate the possible effects of regularly performed moderate-intensity exercise on thiol/disulfide homeostasis, and IMA levels.Methods: Sprague Dawley rats were used. The study was composed of an Exercise group (EG, n=9) and Control group (CG, n=6). A 10-weeks swimming exercise was performed. Thiol/disulfide homeostasis measurement method was used in this study. IMA levels were measured by a cobalt-albumin binding method.Results: In the EG, total thiol levels were significantly higher compared to the CG (p&lt;0.01). The disulfide/total thiol ratio was lower in the EG compared to the CG (p&lt;0.01). We observed that there was a slight increase in IMA levels in EG (p=0.18). This increase was not statistically significant.Conclusion: Regularly performed moderate-intensity exercise has increased native and total thiol levels. Increase of thiol levels can prevent oxidative stress. Regularly performed moderate-intensity exercise programs appear to provide favourable effects on oxidative stress.  Amaç: Tiyol/disülfid homeostazı, oksidatif stresin ve antioksidan kapasitenin bir göstergesidir. İskemi-modifiye albümin (İMA), hem oksidatif stres hem de iskemi için önemli bir belirteçtir. Düzenli olarak uygulanan orta şiddetteki egzersizin tiyol/disülfid homeostazı ve IMA seviyeleri üzerine olası etkilerini değerlendirmeyi amaçladık.Yöntemler: Sprague-Dawley sıçanlar kullanıldı. Çalışma, Egzersiz grubu (EG, n=9) ve Kontrol grubundan (KG, n=6) oluşturuldu. 10 haftalık bir yüzme egzersizi yaptırıldı. Bu çalışmada tiyol/disülfid homeostazı ölçüm yöntemi kullanıldı. İMA seviyeleri, bir kobalt-albümin bağlama yöntemiyle ölçüldü.Bulgular: EG'de, total tiyol seviyeleri KG ile karşılaştırıldığında anlamlı derecede daha yüksekti (p&lt;0.01). Disülfid/total tiyol oranı EG’da KG ile karşılaştırıldığında daha düşüktü (p&lt;0.01). EG'da IMA seviyelerinde hafif bir artış olduğunu gözlemledik (p=0,18). Bu artış istatistiksel olarak anlamlı değildi.Sonuç: Düzenli olarak uygulanan orta şiddetteki egzersiz, nativ ve total tiyol seviyelerini artırdı. Tiyol seviyelerinin artması oksidatif stresi önleyebilir. Düzenli olarak uygulanan orta şiddetteki egzersiz programlarının oksidatif stres üzerinde olumlu etkiler sağladığı görülmektedir.</abstract><doi>10.30565/medalanya.1055424</doi><orcidid>https://orcid.org/0000-0002-0974-5717</orcidid><orcidid>https://orcid.org/0000-0002-2996-3236</orcidid><orcidid>https://orcid.org/0000-0002-6979-9469</orcidid><orcidid>https://orcid.org/0000-0002-3275-1234</orcidid><orcidid>https://orcid.org/0000-0002-0770-2692</orcidid><orcidid>https://orcid.org/0000-0002-0610-0526</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 2587-0319
ispartof Acta medica Alanya, 2022-08, Vol.6 (2), p.120-125
issn 2587-0319
2587-0319
language eng
recordid cdi_crossref_primary_10_30565_medalanya_1055424
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
title The effect of regularly performed moderate-intensity exercise program on thiol/disulfide homeostasis, and ischemia-modified albumin
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T08%3A15%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20regularly%20performed%20moderate-intensity%20exercise%20program%20on%20thiol/disulfide%20homeostasis,%20and%20ischemia-modified%20albumin&rft.jtitle=Acta%20medica%20Alanya&rft.au=PALA,%20Mukaddes&rft.date=2022-08-20&rft.volume=6&rft.issue=2&rft.spage=120&rft.epage=125&rft.pages=120-125&rft.issn=2587-0319&rft.eissn=2587-0319&rft_id=info:doi/10.30565/medalanya.1055424&rft_dat=%3Ccrossref%3E10_30565_medalanya_1055424%3C/crossref%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true