Sub-acute Toxicosis Caused by a Multiple Doses Tegafur/Uracil (UFT) for Suicide : A Case Report
Tegafur/uracil (UFT) is an oral anticancer drug composed of tegafur which is a derivative of fluorouracil (5-FU) and uracil in a molar ratio of 1 : 4. UFT is effective as adjuvant chemotherapy for breast cancer2, colorectal cancer3, non-small cell lung carcinoma4, head and neck cancer5 and other tum...
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| Veröffentlicht in: | Kita Kantō igaku (The Kitakanto Medical Journal) 2007/11/01, Vol.57(4), pp.317-320 |
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| container_title | Kita Kantō igaku (The Kitakanto Medical Journal) |
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| creator | Hagiwara, Shuichi Ogino, Takashi Takahashi, Yuga Isaka, Akira Nameki, Taro Kagoshima, Kaie Yamada, Takuro Ishihara, Kouichi Hiraishi, Hikaru Kurabayashi, Kazutaka Handa, Hiroshi Iino, Yuichi |
| description | Tegafur/uracil (UFT) is an oral anticancer drug composed of tegafur which is a derivative of fluorouracil (5-FU) and uracil in a molar ratio of 1 : 4. UFT is effective as adjuvant chemotherapy for breast cancer2, colorectal cancer3, non-small cell lung carcinoma4, head and neck cancer5 and other tumors. We report a 41-year-old man who orally ingested a large dose of UFT (tegafur : 40000 mg/uracil 9960mg) in an effort to commit suicide, and suffered from sub-acute toxicosis (main symptoms were bone-marrow suppression, and hair loss) of UFT. His life was saved by empiric antibiotic chemical treatment (meropenem, isapamicin, and micafungin), and granulocyte colony-stimulating factor (G-CSF). In the case of toxicosis of UFT, strong antibacterial empiric chemotherapy and G-CSF are necessary for rescue. If G-CSF is not work, biopsy of bone marrow woud be necessary, and the case of no stem cells, bone marrow transfusion should be thought. |
| doi_str_mv | 10.2974/kmj.57.317 |
| format | Article |
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If G-CSF is not work, biopsy of bone marrow woud be necessary, and the case of no stem cells, bone marrow transfusion should be thought.</description><subject>pancytopenia</subject><subject>suicide attempt</subject><subject>tegafur/uracil (UFT)</subject><subject>toxicosis</subject><issn>1343-2826</issn><issn>1881-1191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNo9UMtKAzEUHUTB58YvyFKFafNsGjdSqlWhIth2HZLMTU077ZRkBuzfG6m6uefCPY_LKYprgntUSd5fb1Y9IXuMyKPijAyHpCREkeO8M85KOqSD0-I8pRXGYqAYPyv0rLOlcV0LaN58BdekkNDYdAkqZPfIoLeubsOuBvTYJEhoDkvju9hfRONCjW4Wk_kt8k1Esy64UAG6R6OsT4A-YNfE9rI48aZOcPWLF8Vi8jQfv5TT9-fX8WhaOkGxLIe4GgyssBYcFdJUginjveNCeuBgZUUcw9QJL7ziFEAZBowQrJS1SljGLoq7g6-LTUoRvN7FsDFxrwnWP9XoXI0WUudqMnlyIG-gCs7UzbYOW9Crpovb_KSugK1Da9aaYix17kpinoFpnNV5UKykZFxlo4eD0Sq1Zgn_mSa2wdXwl8kP40f8d3GfJmrYsm9HWYNW</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Hagiwara, Shuichi</creator><creator>Ogino, Takashi</creator><creator>Takahashi, Yuga</creator><creator>Isaka, Akira</creator><creator>Nameki, Taro</creator><creator>Kagoshima, Kaie</creator><creator>Yamada, Takuro</creator><creator>Ishihara, Kouichi</creator><creator>Hiraishi, Hikaru</creator><creator>Kurabayashi, Kazutaka</creator><creator>Handa, Hiroshi</creator><creator>Iino, Yuichi</creator><general>The Kitakanto Medical Society</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200711</creationdate><title>Sub-acute Toxicosis Caused by a Multiple Doses Tegafur/Uracil (UFT) for Suicide : A Case Report</title><author>Hagiwara, Shuichi ; Ogino, Takashi ; Takahashi, Yuga ; Isaka, Akira ; Nameki, Taro ; Kagoshima, Kaie ; Yamada, Takuro ; Ishihara, Kouichi ; Hiraishi, Hikaru ; Kurabayashi, Kazutaka ; Handa, Hiroshi ; Iino, Yuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5207-80d66b5bbec257ad539affc457fe4eb7d1c302c5f5f942ee9a3e311099bb95b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>pancytopenia</topic><topic>suicide attempt</topic><topic>tegafur/uracil (UFT)</topic><topic>toxicosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hagiwara, Shuichi</creatorcontrib><creatorcontrib>Ogino, Takashi</creatorcontrib><creatorcontrib>Takahashi, Yuga</creatorcontrib><creatorcontrib>Isaka, Akira</creatorcontrib><creatorcontrib>Nameki, Taro</creatorcontrib><creatorcontrib>Kagoshima, Kaie</creatorcontrib><creatorcontrib>Yamada, Takuro</creatorcontrib><creatorcontrib>Ishihara, Kouichi</creatorcontrib><creatorcontrib>Hiraishi, Hikaru</creatorcontrib><creatorcontrib>Kurabayashi, Kazutaka</creatorcontrib><creatorcontrib>Handa, Hiroshi</creatorcontrib><creatorcontrib>Iino, Yuichi</creatorcontrib><creatorcontrib>Graduate School of Medicine</creatorcontrib><creatorcontrib>Department of Medicine and Clinical Science</creatorcontrib><creatorcontrib>Gunma University</creatorcontrib><creatorcontrib>Department of Emergency Medicine</creatorcontrib><collection>CrossRef</collection><jtitle>Kita Kantō igaku (The Kitakanto Medical Journal)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hagiwara, Shuichi</au><au>Ogino, Takashi</au><au>Takahashi, Yuga</au><au>Isaka, Akira</au><au>Nameki, Taro</au><au>Kagoshima, Kaie</au><au>Yamada, Takuro</au><au>Ishihara, Kouichi</au><au>Hiraishi, Hikaru</au><au>Kurabayashi, Kazutaka</au><au>Handa, Hiroshi</au><au>Iino, Yuichi</au><aucorp>Graduate School of Medicine</aucorp><aucorp>Department of Medicine and Clinical Science</aucorp><aucorp>Gunma University</aucorp><aucorp>Department of Emergency Medicine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sub-acute Toxicosis Caused by a Multiple Doses Tegafur/Uracil (UFT) for Suicide : A Case Report</atitle><jtitle>Kita Kantō igaku (The Kitakanto Medical Journal)</jtitle><addtitle>Kitakanto Med J</addtitle><date>2007-11</date><risdate>2007</risdate><volume>57</volume><issue>4</issue><spage>317</spage><epage>320</epage><pages>317-320</pages><issn>1343-2826</issn><eissn>1881-1191</eissn><abstract>Tegafur/uracil (UFT) is an oral anticancer drug composed of tegafur which is a derivative of fluorouracil (5-FU) and uracil in a molar ratio of 1 : 4. 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| language | eng |
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| source | Freely Accessible Japanese Titles (ERDB Project); J-STAGE (Free - Japanese); EZB Electronic Journals Library |
| subjects | pancytopenia suicide attempt tegafur/uracil (UFT) toxicosis |
| title | Sub-acute Toxicosis Caused by a Multiple Doses Tegafur/Uracil (UFT) for Suicide : A Case Report |
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