89 Zr-3,2-HOPO-Mesothelin Antibody PET Imaging Reflects Tumor Uptake of Mesothelin-Targeted 227 Th-Conjugate Therapy in Mice

The mesothelin (MSLN)-targeted Th conjugate is a novel α-therapy developed to treat MSLN-overexpressing cancers. We radiolabeled the same antibody-chelator conjugate with Zr to evaluate whether PET imaging with Zr-MSLN matches Th-MSLN tumor uptake, biodistribution, and antitumor activity. Serial PET...

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Veröffentlicht in:	Journal of Nuclear Medicine 2022-11, Vol.63 (11), p.1715
Hauptverfasser:	Broer, Linda N, Knapen, Daan G, Suurs, Frans V, Moen, Ingrid, Giesen, Danique, Waaijer, Stijn J H, Indrevoll, Baard, Ellingsen, Christine, Kristian, Alexander, Cuthbertson, Alan S, de Groot, Derk-Jan A, Cole, Patricia E, de Vries, Elisabeth G E, Hagemann, Urs B, Lub-de Hooge, Marjolijn N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Line, Tumor Chelating Agents Female Humans Immunoconjugates Mesothelin Mice Mice, Nude Ovarian Neoplasms Positron-Emission Tomography - methods Tissue Distribution Zirconium - therapeutic use
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