Direct Comparison of the Tau PET Tracers 18 F-Flortaucipir and 18 F-MK-6240 in Human Subjects

Tau PET tracers exhibit varying levels of specific signal and distinct off-target binding patterns that are more diverse than amyloid PET tracers. This study compared 2 frequently used tau PET tracers, F-flortaucipir and F-MK-6240, in the same subjects. F-flortaucipir and F-MK-6240 scans were collec...

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Veröffentlicht in:	Journal of Nuclear Medicine 2022-01, Vol.63 (1), p.108-116
Hauptverfasser:	Gogola, Alexandra, Minhas, Davneet S, Villemagne, Victor L, Cohen, Ann D, Mountz, James M, Pascoal, Tharick A, Laymon, Charles M, Mason, N Scott, Ikonomovic, Milos D, Mathis, Chester A, Snitz, Beth E, Lopez, Oscar L, Klunk, William E, Lopresti, Brian J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Brain - diagnostic imaging Brain - metabolism Carbolines - pharmacokinetics Female Fluorine Radioisotopes Humans Isoquinolines Male Middle Aged Positron-Emission Tomography - methods Radiopharmaceuticals - pharmacokinetics tau Proteins - metabolism
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