11 C-PBR28 and 18 F-PBR111 Detect White Matter Inflammatory Heterogeneity in Multiple Sclerosis

The objective of this study was to assess microglial activation in lesions and in normal-appearing white matter (NAWM) of multiple sclerosis (MS) patients using PET. Thirty-four MS patients (7 with secondary progressive MS [SPMS], 27 with relapsing remitting MS [RRMS]) and 30 healthy volunteers, gen...

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Veröffentlicht in:	Journal of Nuclear Medicine 2017-09, Vol.58 (9), p.1477-1482
Hauptverfasser:	Datta, Gourab, Colasanti, Alessandro, Kalk, Nicola, Owen, David, Scott, Gregory, Rabiner, Eugenii A, Gunn, Roger N, Lingford-Hughes, Anne, Malik, Omar, Ciccarelli, Olga, Nicholas, Richard, Nei, Lei, Battaglini, Marco, De Stefano, Nicola, Matthews, Paul M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological Transport Brain - diagnostic imaging Brain - metabolism Female Humans Inflammation - diagnostic imaging Ligands Male Middle Aged Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - metabolism Positron-Emission Tomography Pyridines - metabolism Pyrimidines - metabolism White Matter - diagnostic imaging White Matter - metabolism
Online-Zugang:	Volltext
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