Multi-center clinical studies for strategies to improve patients' accessibility to peginterferon therapy: Consideration based on both prospective study and retrospective study
To evaluate whether start-up of peginterferon therapy for chronic hepatitis C at out-patient clinic may improve patients' accessibility, multi-center clinical studies were performed. In retrospective study with 879 patients who had already finished peginterferon (plus ribavirin) therapy, adhere...
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| Veröffentlicht in: | Kanzo 2010, Vol.51(7), pp.348-360 |
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| creator | Masaki, Naohiko Nishimura, Sou Inbe, Kou Yamada, Akihiro Yanase, Mikio Yano, Kouji Itoh, Kiyoaki Imamura, Masatoshi Itoh, Kazuki Gibo, Yukio Kaito, Masahiko Kawakami, Yoshiiku Kawakami, Hiroiku Hatakeyama, Shigeaki Komatsu, Masafumi Kim, Soo Ryang Yatsuhashi, Hiroshi Izumi, Namiki Nomura, Hideyuki Saibara, Toshiji Nakao, Haruhisa Yoneda, Masashi Hiramatsu, Naoki Hayashi, Norio Mizokami, Masashi |
| description | To evaluate whether start-up of peginterferon therapy for chronic hepatitis C at out-patient clinic may improve patients' accessibility, multi-center clinical studies were performed. In retrospective study with 879 patients who had already finished peginterferon (plus ribavirin) therapy, adherence to treatment regimen and final virological response were quite similar in both modes of start-up (at hospitalization or at out-patient clinic). In addition, interruption rate was rather lower in patients with start-up at out-patient clinic than in those at hospitalization. In prospective study, unsigned questionnaires about modes of start-up were carried out. Twenty-two out of 38 (58%) patients who started up peginterferon therapy at hospitalization preferred shorter hospital stays or start-up at out-patient clinic. In contrast, fifty-nine out of 73 (81%) patients who started up at out-patient clinic were completely satisfied. These lines of evidence may suggest start-up at out-patient clinic is fully safe and improves patients' accessibility to peginterferon therapy. |
| doi_str_mv | 10.2957/kanzo.51.348 |
| format | Article |
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In retrospective study with 879 patients who had already finished peginterferon (plus ribavirin) therapy, adherence to treatment regimen and final virological response were quite similar in both modes of start-up (at hospitalization or at out-patient clinic). In addition, interruption rate was rather lower in patients with start-up at out-patient clinic than in those at hospitalization. In prospective study, unsigned questionnaires about modes of start-up were carried out. Twenty-two out of 38 (58%) patients who started up peginterferon therapy at hospitalization preferred shorter hospital stays or start-up at out-patient clinic. In contrast, fifty-nine out of 73 (81%) patients who started up at out-patient clinic were completely satisfied. These lines of evidence may suggest start-up at out-patient clinic is fully safe and improves patients' accessibility to peginterferon therapy.</description><identifier>ISSN: 0451-4203</identifier><identifier>EISSN: 1881-3593</identifier><identifier>DOI: 10.2957/kanzo.51.348</identifier><language>jpn</language><publisher>The Japan Society of Hepatology</publisher><subject>chronic hepatitis C ; peginterferon ; ribavirin ; start-up at hospitalization ; start-up at out-patient clinic</subject><ispartof>Kanzo, 2010, Vol.51(7), pp.348-360</ispartof><rights>2010 The Japan Society of Hepatology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2468-844eff1955a3b329fc25e88e4a45e0b672b0f761598a5a35ca4e0dc3e6df559d3</citedby><cites>FETCH-LOGICAL-c2468-844eff1955a3b329fc25e88e4a45e0b672b0f761598a5a35ca4e0dc3e6df559d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Masaki, Naohiko</creatorcontrib><creatorcontrib>Nishimura, Sou</creatorcontrib><creatorcontrib>Inbe, Kou</creatorcontrib><creatorcontrib>Yamada, Akihiro</creatorcontrib><creatorcontrib>Yanase, Mikio</creatorcontrib><creatorcontrib>Yano, Kouji</creatorcontrib><creatorcontrib>Itoh, Kiyoaki</creatorcontrib><creatorcontrib>Imamura, Masatoshi</creatorcontrib><creatorcontrib>Itoh, Kazuki</creatorcontrib><creatorcontrib>Gibo, Yukio</creatorcontrib><creatorcontrib>Kaito, Masahiko</creatorcontrib><creatorcontrib>Kawakami, Yoshiiku</creatorcontrib><creatorcontrib>Kawakami, Hiroiku</creatorcontrib><creatorcontrib>Hatakeyama, Shigeaki</creatorcontrib><creatorcontrib>Komatsu, Masafumi</creatorcontrib><creatorcontrib>Kim, Soo Ryang</creatorcontrib><creatorcontrib>Yatsuhashi, Hiroshi</creatorcontrib><creatorcontrib>Izumi, Namiki</creatorcontrib><creatorcontrib>Nomura, Hideyuki</creatorcontrib><creatorcontrib>Saibara, Toshiji</creatorcontrib><creatorcontrib>Nakao, Haruhisa</creatorcontrib><creatorcontrib>Yoneda, Masashi</creatorcontrib><creatorcontrib>Hiramatsu, Naoki</creatorcontrib><creatorcontrib>Hayashi, Norio</creatorcontrib><creatorcontrib>Mizokami, Masashi</creatorcontrib><title>Multi-center clinical studies for strategies to improve patients' accessibility to peginterferon therapy: Consideration based on both prospective study and retrospective study</title><title>Kanzo</title><addtitle>Kanzo</addtitle><description>To evaluate whether start-up of peginterferon therapy for chronic hepatitis C at out-patient clinic may improve patients' accessibility, multi-center clinical studies were performed. In retrospective study with 879 patients who had already finished peginterferon (plus ribavirin) therapy, adherence to treatment regimen and final virological response were quite similar in both modes of start-up (at hospitalization or at out-patient clinic). In addition, interruption rate was rather lower in patients with start-up at out-patient clinic than in those at hospitalization. In prospective study, unsigned questionnaires about modes of start-up were carried out. Twenty-two out of 38 (58%) patients who started up peginterferon therapy at hospitalization preferred shorter hospital stays or start-up at out-patient clinic. In contrast, fifty-nine out of 73 (81%) patients who started up at out-patient clinic were completely satisfied. These lines of evidence may suggest start-up at out-patient clinic is fully safe and improves patients' accessibility to peginterferon therapy.</description><subject>chronic hepatitis C</subject><subject>peginterferon</subject><subject>ribavirin</subject><subject>start-up at hospitalization</subject><subject>start-up at out-patient clinic</subject><issn>0451-4203</issn><issn>1881-3593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNpdkMtOwzAQRS0EEhV0xwd4x4YUO7bzYFdVvKQiNrCOJs64NaRJZLtI5af4RRyKisTG8_CZO6NLyAVns7RU-fU7dJ_9TPGZkMURmfCi4IlQpTgmEyYVT2TKxCmZem9rxtIsZ2WZTsjX07YNNtHYBXRUt7azGlrqw7ax6KnpXcwdBFyNZeip3Qyu_0A6QLBxyF9S0BpHVdvasBuRIcKjnEHXdzSs0cGwu6GLvvO2iUWwsV2Dx4aOSR_WNGr6AXWwUXncvaPQNdRh-N8_JycGWo_T33hGXu9uXxYPyfL5_nExXyY6lVmRFFKiMbxUCkQt0tLoVGFRoASpkNVZntbM5BlXZQERURokskYLzBqjVNmIM3K119XxAu_QVIOzG3C7irNq9Lv68btSvIp-R3y-x998gBUeYHDB6hb_4Hz_xJnDn16Dq7AT39-GkvI</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Masaki, Naohiko</creator><creator>Nishimura, Sou</creator><creator>Inbe, Kou</creator><creator>Yamada, Akihiro</creator><creator>Yanase, Mikio</creator><creator>Yano, Kouji</creator><creator>Itoh, Kiyoaki</creator><creator>Imamura, Masatoshi</creator><creator>Itoh, Kazuki</creator><creator>Gibo, Yukio</creator><creator>Kaito, Masahiko</creator><creator>Kawakami, Yoshiiku</creator><creator>Kawakami, Hiroiku</creator><creator>Hatakeyama, Shigeaki</creator><creator>Komatsu, Masafumi</creator><creator>Kim, Soo Ryang</creator><creator>Yatsuhashi, Hiroshi</creator><creator>Izumi, Namiki</creator><creator>Nomura, Hideyuki</creator><creator>Saibara, Toshiji</creator><creator>Nakao, Haruhisa</creator><creator>Yoneda, Masashi</creator><creator>Hiramatsu, Naoki</creator><creator>Hayashi, Norio</creator><creator>Mizokami, Masashi</creator><general>The Japan Society of Hepatology</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2010</creationdate><title>Multi-center clinical studies for strategies to improve patients' accessibility to peginterferon therapy: Consideration based on both prospective study and retrospective study</title><author>Masaki, Naohiko ; Nishimura, Sou ; Inbe, Kou ; Yamada, Akihiro ; Yanase, Mikio ; Yano, Kouji ; Itoh, Kiyoaki ; Imamura, Masatoshi ; Itoh, Kazuki ; Gibo, Yukio ; Kaito, Masahiko ; Kawakami, Yoshiiku ; Kawakami, Hiroiku ; Hatakeyama, Shigeaki ; Komatsu, Masafumi ; Kim, Soo Ryang ; Yatsuhashi, Hiroshi ; Izumi, Namiki ; Nomura, Hideyuki ; Saibara, Toshiji ; Nakao, Haruhisa ; Yoneda, Masashi ; Hiramatsu, Naoki ; Hayashi, Norio ; Mizokami, Masashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2468-844eff1955a3b329fc25e88e4a45e0b672b0f761598a5a35ca4e0dc3e6df559d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>2010</creationdate><topic>chronic hepatitis C</topic><topic>peginterferon</topic><topic>ribavirin</topic><topic>start-up at hospitalization</topic><topic>start-up at out-patient clinic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masaki, Naohiko</creatorcontrib><creatorcontrib>Nishimura, Sou</creatorcontrib><creatorcontrib>Inbe, Kou</creatorcontrib><creatorcontrib>Yamada, Akihiro</creatorcontrib><creatorcontrib>Yanase, Mikio</creatorcontrib><creatorcontrib>Yano, Kouji</creatorcontrib><creatorcontrib>Itoh, Kiyoaki</creatorcontrib><creatorcontrib>Imamura, Masatoshi</creatorcontrib><creatorcontrib>Itoh, Kazuki</creatorcontrib><creatorcontrib>Gibo, Yukio</creatorcontrib><creatorcontrib>Kaito, Masahiko</creatorcontrib><creatorcontrib>Kawakami, Yoshiiku</creatorcontrib><creatorcontrib>Kawakami, Hiroiku</creatorcontrib><creatorcontrib>Hatakeyama, Shigeaki</creatorcontrib><creatorcontrib>Komatsu, Masafumi</creatorcontrib><creatorcontrib>Kim, Soo Ryang</creatorcontrib><creatorcontrib>Yatsuhashi, Hiroshi</creatorcontrib><creatorcontrib>Izumi, Namiki</creatorcontrib><creatorcontrib>Nomura, Hideyuki</creatorcontrib><creatorcontrib>Saibara, Toshiji</creatorcontrib><creatorcontrib>Nakao, Haruhisa</creatorcontrib><creatorcontrib>Yoneda, Masashi</creatorcontrib><creatorcontrib>Hiramatsu, Naoki</creatorcontrib><creatorcontrib>Hayashi, Norio</creatorcontrib><creatorcontrib>Mizokami, Masashi</creatorcontrib><collection>CrossRef</collection><jtitle>Kanzo</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masaki, Naohiko</au><au>Nishimura, Sou</au><au>Inbe, Kou</au><au>Yamada, Akihiro</au><au>Yanase, Mikio</au><au>Yano, Kouji</au><au>Itoh, Kiyoaki</au><au>Imamura, Masatoshi</au><au>Itoh, Kazuki</au><au>Gibo, Yukio</au><au>Kaito, Masahiko</au><au>Kawakami, Yoshiiku</au><au>Kawakami, Hiroiku</au><au>Hatakeyama, Shigeaki</au><au>Komatsu, Masafumi</au><au>Kim, Soo Ryang</au><au>Yatsuhashi, Hiroshi</au><au>Izumi, Namiki</au><au>Nomura, Hideyuki</au><au>Saibara, Toshiji</au><au>Nakao, Haruhisa</au><au>Yoneda, Masashi</au><au>Hiramatsu, Naoki</au><au>Hayashi, Norio</au><au>Mizokami, Masashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multi-center clinical studies for strategies to improve patients' accessibility to peginterferon therapy: Consideration based on both prospective study and retrospective study</atitle><jtitle>Kanzo</jtitle><addtitle>Kanzo</addtitle><date>2010</date><risdate>2010</risdate><volume>51</volume><issue>7</issue><spage>348</spage><epage>360</epage><pages>348-360</pages><issn>0451-4203</issn><eissn>1881-3593</eissn><abstract>To evaluate whether start-up of peginterferon therapy for chronic hepatitis C at out-patient clinic may improve patients' accessibility, multi-center clinical studies were performed. In retrospective study with 879 patients who had already finished peginterferon (plus ribavirin) therapy, adherence to treatment regimen and final virological response were quite similar in both modes of start-up (at hospitalization or at out-patient clinic). In addition, interruption rate was rather lower in patients with start-up at out-patient clinic than in those at hospitalization. In prospective study, unsigned questionnaires about modes of start-up were carried out. Twenty-two out of 38 (58%) patients who started up peginterferon therapy at hospitalization preferred shorter hospital stays or start-up at out-patient clinic. In contrast, fifty-nine out of 73 (81%) patients who started up at out-patient clinic were completely satisfied. These lines of evidence may suggest start-up at out-patient clinic is fully safe and improves patients' accessibility to peginterferon therapy.</abstract><pub>The Japan Society of Hepatology</pub><doi>10.2957/kanzo.51.348</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0451-4203 |
| ispartof | Kanzo, 2010, Vol.51(7), pp.348-360 |
| issn | 0451-4203 1881-3593 |
| language | jpn |
| recordid | cdi_crossref_primary_10_2957_kanzo_51_348 |
| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals |
| subjects | chronic hepatitis C peginterferon ribavirin start-up at hospitalization start-up at out-patient clinic |
| title | Multi-center clinical studies for strategies to improve patients' accessibility to peginterferon therapy: Consideration based on both prospective study and retrospective study |
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