A case of chronic hepatitis type C showing hypermacrocreatinine-kinasenemia during interferon therapy

A 64-year-old male was admitted for the treatment of chronic hepatitis type C. Interferon (IFN)-α, (600 million units intramuscular injection) was started every day for 2 weeks and thereafter 3 times a week for 5.5 months, and HCV·RNA in serum rapidly disappeared. Creatinine kinase (CK), lactate deh...

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Veröffentlicht in:Kanzo 1996/05/25, Vol.37(5), pp.264-267
Hauptverfasser: KARIYAMA, Kazuya, HIGASHI, Toshihiro, TANI, Hideki, UESU, Tokurou, HIGUCHI, Shinnosuke, KASAHARA, Jyunji, KATO, Tomohiro, IWADO, Hironori, TSUJI, Takao
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Sprache:jpn
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Zusammenfassung:A 64-year-old male was admitted for the treatment of chronic hepatitis type C. Interferon (IFN)-α, (600 million units intramuscular injection) was started every day for 2 weeks and thereafter 3 times a week for 5.5 months, and HCV·RNA in serum rapidly disappeared. Creatinine kinase (CK), lactate dehydrogease (LDH), aldolase, myoglobulin and toroponin in serum elevated at the end of the IFN therapy, and these myogenic enzymes gradually decreased and returned to the normal limits after the treatment was finished. The CK isoenzyme pattern showed that MM fraction was predominant and there was an extra-band which was proved to be a macro-CK bound to IgA-λ. Although particular symptoms, including muscle pain and atrophy, were not recognized during the therapy, it was suggested that asymptomatic myopathy developed as a side effect of the IFN therapy. Since IFN-induced myopathy has rarely been reported, myopathy should be taken into account when myogenic enzymes, including CK, are elevated during the therapy.
ISSN:0451-4203
1881-3593
DOI:10.2957/kanzo.37.264