Significance of IgA type of anti-Hbc in children with chronic HBV infection

Significance of IgA type of anti-Hbc in children with chronic HBV infection

Significance of IgA type of anti-HBc (IgA-HBcAb) was studied in 47 children with chronically infected HBV. As liver damages developed, titers of IgA-HBcAb elevated regardless of age, sex, and status of HBe antigen/antibody system. Anti-HBc measured by RIA or PHA, IgA1, IgA2, and secretory component...

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Veröffentlicht in:Kanzo 1992/08/25, Vol.33(8), pp.585-590
Hauptverfasser: KAGIMOTO, Seiichi, FUJITSUKA, Satoshi, ONOUE, Masahiro, KINOSHITA, Keiji, FUJISAWA, Tomoo, HINO, Kunihiko
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Sprache:jpn
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chronic hepatitis
HB carrier
hepatitis B in childhood
IgA-HBc antibody
liver dysfunction
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container_end_page 590
container_issue 8
container_start_page 585
container_title Kanzo
container_volume 33
creator KAGIMOTO, Seiichi
FUJITSUKA, Satoshi
ONOUE, Masahiro
KINOSHITA, Keiji
FUJISAWA, Tomoo
HINO, Kunihiko
description Significance of IgA type of anti-HBc (IgA-HBcAb) was studied in 47 children with chronically infected HBV. As liver damages developed, titers of IgA-HBcAb elevated regardless of age, sex, and status of HBe antigen/antibody system. Anti-HBc measured by RIA or PHA, IgA1, IgA2, and secretory component of IgA type of anti-HBc correlated with IgA-HBcAb, but they had weaker relation to liver damage than IgA1 which had strong correlation with IgA-HBcAb. IgA-HBcAb declined swiftly in accordance with recovery of liver damage in a child with chronic hepatitis. IgA-HBcAb remained at low levels when hepatitis C occurred in an asymptomatic carrier child having HBV. IgA-HBcAb, having good specificity and sensitivity as an indicator of liver damage due to HBV infection, is clinically useful.
doi_str_mv 10.2957/kanzo.33.585
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subjects chronic hepatitis
HB carrier
hepatitis B in childhood
IgA-HBc antibody
liver dysfunction
title Significance of IgA type of anti-Hbc in children with chronic HBV infection
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