In vivo 1H- and 31P-MR spectroscopy of the fatty liver in monosodium glutamate-treated rats

In vivo 1H- and 31P-MR spectroscopy of the fatty liver in monosodium glutamate-treated rats

The livers of monosodium glutamate (MSG)-treated rats and normal control rats were investigated in vivo using 1H- and 31P-magnetic resonance (MR) spectroscopy. The liver of MSG-treated rats showed a remarkable fatty change histologically and their triglyceride content was much greater than that in c...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Kanzo 1990/09/25, Vol.31(9), pp.1070-1077
Hauptverfasser: HAYASHI, Shinta, TAMAI, Toshitaka, OIDA, Koji, NAKAI, Tsuguhiko, MIYABO, Susumu
Format: Artikel
Sprache:jpn
Schlagworte:
1H-MRS
31P-MRS
MSG (monosodium glutamate)
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1077
container_issue 9
container_start_page 1070
container_title Kanzo
container_volume 31
creator HAYASHI, Shinta
TAMAI, Toshitaka
OIDA, Koji
NAKAI, Tsuguhiko
MIYABO, Susumu
description The livers of monosodium glutamate (MSG)-treated rats and normal control rats were investigated in vivo using 1H- and 31P-magnetic resonance (MR) spectroscopy. The liver of MSG-treated rats showed a remarkable fatty change histologically and their triglyceride content was much greater than that in control rats. 1H-MR spectra of MSG-treated rats showed an obvious fat peak in addition to a water peak. There was an excellent correlation between the peak area ratio of fat to fat plus water obtained from 1H-MR spectroscopy in vivo and triglyceride content in the liver specimens measured by a thinlayer-chromatography-flame-ionization (TLC-FID) metbod. 31P-MR spectra of both MSG-treated and control rats revealed 6 peaks, which were assigned to phosphomonoester (PME), inorganic phosphate (Pi), phosphodiester (PDE), γ-ATP, α-ATP, β-ATP. The peak height ratio of Pi to α-ATP was higher in MSG-treated rats than in control rats. The chemical shift of Pi relative to α-ATP was smaller in MSG-treated rats than in control rats, suggesting a slight acidosis in the liver of MSG-treated rats. These data demonstrated that 1H- and 31P-MR spectroscopy were useful for evaluation of accumulation of fat and related metabolic derangements in fatty liver.
doi_str_mv 10.2957/kanzo.31.1070
format Article
fullrecord <record><control><sourceid>jstage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_2957_kanzo_31_1070</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>article_kanzo1960_31_9_31_9_1070_article_char_en</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1970-4f971329fe5e1eb72ee4f442e3934bdcc95372b1f2b0236c5053c084064e89d73</originalsourceid><addsrcrecordid>eNo9kM9LwzAYhoMoOHRH7_kHMvOrTXOU4dxgooiePJQ0_bJV22Yk2WD-9a5Wdvney_O-fDwI3TE64zpT99-m__EzwWaMKnqBJqwoGBGZFpdoQmXGiORUXKNpjE1FKc8V1ZpP0Oeqx4fm4DFbEmz6Ggv2Sp7fcNyBTcFH63dH7B1OW8DOpHTEbXOAgJsed7730dfNvsObdp9MZxKQFOAUNQ4mxVt05UwbYfqfN-hj8fg-X5L1y9Nq_rAmlmlFiXRaMcG1gwwYVIoDSCclB6GFrGprdSYUr5jjFeUitxnNhKWFpLmEQtdK3CAy7trTwzGAK3eh6Uw4loyWg5zyT04pWDnIOfGLkf-KyWzgTJuQGtvCSDOd06GhxzMUz4DdmlBCL34BpthwrA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>In vivo 1H- and 31P-MR spectroscopy of the fatty liver in monosodium glutamate-treated rats</title><source>J-STAGE (Japan Science &amp; Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>HAYASHI, Shinta ; TAMAI, Toshitaka ; OIDA, Koji ; NAKAI, Tsuguhiko ; MIYABO, Susumu</creator><creatorcontrib>HAYASHI, Shinta ; TAMAI, Toshitaka ; OIDA, Koji ; NAKAI, Tsuguhiko ; MIYABO, Susumu</creatorcontrib><description>The livers of monosodium glutamate (MSG)-treated rats and normal control rats were investigated in vivo using 1H- and 31P-magnetic resonance (MR) spectroscopy. The liver of MSG-treated rats showed a remarkable fatty change histologically and their triglyceride content was much greater than that in control rats. 1H-MR spectra of MSG-treated rats showed an obvious fat peak in addition to a water peak. There was an excellent correlation between the peak area ratio of fat to fat plus water obtained from 1H-MR spectroscopy in vivo and triglyceride content in the liver specimens measured by a thinlayer-chromatography-flame-ionization (TLC-FID) metbod. 31P-MR spectra of both MSG-treated and control rats revealed 6 peaks, which were assigned to phosphomonoester (PME), inorganic phosphate (Pi), phosphodiester (PDE), γ-ATP, α-ATP, β-ATP. The peak height ratio of Pi to α-ATP was higher in MSG-treated rats than in control rats. The chemical shift of Pi relative to α-ATP was smaller in MSG-treated rats than in control rats, suggesting a slight acidosis in the liver of MSG-treated rats. These data demonstrated that 1H- and 31P-MR spectroscopy were useful for evaluation of accumulation of fat and related metabolic derangements in fatty liver.</description><identifier>ISSN: 0451-4203</identifier><identifier>EISSN: 1881-3593</identifier><identifier>DOI: 10.2957/kanzo.31.1070</identifier><language>jpn</language><publisher>The Japan Society of Hepatology</publisher><subject>1H-MRS ; 31P-MRS ; MSG (monosodium glutamate)</subject><ispartof>Kanzo, 1990/09/25, Vol.31(9), pp.1070-1077</ispartof><rights>The Japan Society of Hepatology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>HAYASHI, Shinta</creatorcontrib><creatorcontrib>TAMAI, Toshitaka</creatorcontrib><creatorcontrib>OIDA, Koji</creatorcontrib><creatorcontrib>NAKAI, Tsuguhiko</creatorcontrib><creatorcontrib>MIYABO, Susumu</creatorcontrib><title>In vivo 1H- and 31P-MR spectroscopy of the fatty liver in monosodium glutamate-treated rats</title><title>Kanzo</title><addtitle>Kanzo</addtitle><description>The livers of monosodium glutamate (MSG)-treated rats and normal control rats were investigated in vivo using 1H- and 31P-magnetic resonance (MR) spectroscopy. The liver of MSG-treated rats showed a remarkable fatty change histologically and their triglyceride content was much greater than that in control rats. 1H-MR spectra of MSG-treated rats showed an obvious fat peak in addition to a water peak. There was an excellent correlation between the peak area ratio of fat to fat plus water obtained from 1H-MR spectroscopy in vivo and triglyceride content in the liver specimens measured by a thinlayer-chromatography-flame-ionization (TLC-FID) metbod. 31P-MR spectra of both MSG-treated and control rats revealed 6 peaks, which were assigned to phosphomonoester (PME), inorganic phosphate (Pi), phosphodiester (PDE), γ-ATP, α-ATP, β-ATP. The peak height ratio of Pi to α-ATP was higher in MSG-treated rats than in control rats. The chemical shift of Pi relative to α-ATP was smaller in MSG-treated rats than in control rats, suggesting a slight acidosis in the liver of MSG-treated rats. These data demonstrated that 1H- and 31P-MR spectroscopy were useful for evaluation of accumulation of fat and related metabolic derangements in fatty liver.</description><subject>1H-MRS</subject><subject>31P-MRS</subject><subject>MSG (monosodium glutamate)</subject><issn>0451-4203</issn><issn>1881-3593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNo9kM9LwzAYhoMoOHRH7_kHMvOrTXOU4dxgooiePJQ0_bJV22Yk2WD-9a5Wdvney_O-fDwI3TE64zpT99-m__EzwWaMKnqBJqwoGBGZFpdoQmXGiORUXKNpjE1FKc8V1ZpP0Oeqx4fm4DFbEmz6Ggv2Sp7fcNyBTcFH63dH7B1OW8DOpHTEbXOAgJsed7730dfNvsObdp9MZxKQFOAUNQ4mxVt05UwbYfqfN-hj8fg-X5L1y9Nq_rAmlmlFiXRaMcG1gwwYVIoDSCclB6GFrGprdSYUr5jjFeUitxnNhKWFpLmEQtdK3CAy7trTwzGAK3eh6Uw4loyWg5zyT04pWDnIOfGLkf-KyWzgTJuQGtvCSDOd06GhxzMUz4DdmlBCL34BpthwrA</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>HAYASHI, Shinta</creator><creator>TAMAI, Toshitaka</creator><creator>OIDA, Koji</creator><creator>NAKAI, Tsuguhiko</creator><creator>MIYABO, Susumu</creator><general>The Japan Society of Hepatology</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1990</creationdate><title>In vivo 1H- and 31P-MR spectroscopy of the fatty liver in monosodium glutamate-treated rats</title><author>HAYASHI, Shinta ; TAMAI, Toshitaka ; OIDA, Koji ; NAKAI, Tsuguhiko ; MIYABO, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1970-4f971329fe5e1eb72ee4f442e3934bdcc95372b1f2b0236c5053c084064e89d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1990</creationdate><topic>1H-MRS</topic><topic>31P-MRS</topic><topic>MSG (monosodium glutamate)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAYASHI, Shinta</creatorcontrib><creatorcontrib>TAMAI, Toshitaka</creatorcontrib><creatorcontrib>OIDA, Koji</creatorcontrib><creatorcontrib>NAKAI, Tsuguhiko</creatorcontrib><creatorcontrib>MIYABO, Susumu</creatorcontrib><collection>CrossRef</collection><jtitle>Kanzo</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAYASHI, Shinta</au><au>TAMAI, Toshitaka</au><au>OIDA, Koji</au><au>NAKAI, Tsuguhiko</au><au>MIYABO, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo 1H- and 31P-MR spectroscopy of the fatty liver in monosodium glutamate-treated rats</atitle><jtitle>Kanzo</jtitle><addtitle>Kanzo</addtitle><date>1990</date><risdate>1990</risdate><volume>31</volume><issue>9</issue><spage>1070</spage><epage>1077</epage><pages>1070-1077</pages><issn>0451-4203</issn><eissn>1881-3593</eissn><abstract>The livers of monosodium glutamate (MSG)-treated rats and normal control rats were investigated in vivo using 1H- and 31P-magnetic resonance (MR) spectroscopy. The liver of MSG-treated rats showed a remarkable fatty change histologically and their triglyceride content was much greater than that in control rats. 1H-MR spectra of MSG-treated rats showed an obvious fat peak in addition to a water peak. There was an excellent correlation between the peak area ratio of fat to fat plus water obtained from 1H-MR spectroscopy in vivo and triglyceride content in the liver specimens measured by a thinlayer-chromatography-flame-ionization (TLC-FID) metbod. 31P-MR spectra of both MSG-treated and control rats revealed 6 peaks, which were assigned to phosphomonoester (PME), inorganic phosphate (Pi), phosphodiester (PDE), γ-ATP, α-ATP, β-ATP. The peak height ratio of Pi to α-ATP was higher in MSG-treated rats than in control rats. The chemical shift of Pi relative to α-ATP was smaller in MSG-treated rats than in control rats, suggesting a slight acidosis in the liver of MSG-treated rats. These data demonstrated that 1H- and 31P-MR spectroscopy were useful for evaluation of accumulation of fat and related metabolic derangements in fatty liver.</abstract><pub>The Japan Society of Hepatology</pub><doi>10.2957/kanzo.31.1070</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0451-4203
ispartof Kanzo, 1990/09/25, Vol.31(9), pp.1070-1077
issn 0451-4203
1881-3593
language jpn
recordid cdi_crossref_primary_10_2957_kanzo_31_1070
source J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese
subjects 1H-MRS
31P-MRS
MSG (monosodium glutamate)
title In vivo 1H- and 31P-MR spectroscopy of the fatty liver in monosodium glutamate-treated rats
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T02%3A21%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstage_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vivo%201H-%20and%2031P-MR%20spectroscopy%20of%20the%20fatty%20liver%20in%20monosodium%20glutamate-treated%20rats&rft.jtitle=Kanzo&rft.au=HAYASHI,%20Shinta&rft.date=1990&rft.volume=31&rft.issue=9&rft.spage=1070&rft.epage=1077&rft.pages=1070-1077&rft.issn=0451-4203&rft.eissn=1881-3593&rft_id=info:doi/10.2957/kanzo.31.1070&rft_dat=%3Cjstage_cross%3Earticle_kanzo1960_31_9_31_9_1070_article_char_en%3C/jstage_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true