Therapeutic effect of estradiol benzoate on primary biliary cirrhosis -A case report

A case of asynptomatic primary biliary cirrhosis (a-PBC) succesfully treated with estradiol benzoate (EB) was reported. This 35-year-old female was admitted to the Kitasato University Hospital complaining of general fatigue. The liver function tests showed a mild elevation of bilirubin, accompained...

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Veröffentlicht in:	Kanzo 1988/12/25, Vol.29(12), pp.1638-1642
Hauptverfasser:	MATSUKI, Shigeki, ISHII, Kohdoh, SHIRASAKI, Keiji, SUGIMOTO, Masanao, NII, Shigenori, KARUBE, Hitomi, KOKUBU, Shigehiro, YAMADA, Nobuo, SHIBATA, Hisao, OKABE, Haruya, OHBU, Makoto, OKUDAIRA, Masahiko
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Sprache:	eng ; jpn
Schlagworte:	PBC
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creator	MATSUKI, Shigeki ISHII, Kohdoh SHIRASAKI, Keiji SUGIMOTO, Masanao NII, Shigenori KARUBE, Hitomi KOKUBU, Shigehiro YAMADA, Nobuo SHIBATA, Hisao OKABE, Haruya OHBU, Makoto OKUDAIRA, Masahiko
description	A case of asynptomatic primary biliary cirrhosis (a-PBC) succesfully treated with estradiol benzoate (EB) was reported. This 35-year-old female was admitted to the Kitasato University Hospital complaining of general fatigue. The liver function tests showed a mild elevation of bilirubin, accompained by an elevation of transaminase, alkaline phosphatase (ALP) and γ-glutamyltranspeptitase (γ-GTP) levels. Serum immnoglobulines of all three major classes were elevated, but elevation of IgM was most conspicuous with the degree of 395mg/100ml. Also demonstrated was positive test for anti-mitochondrial antibody. Biopsy of the liver disclosed PBC (stage 2-3 of Scheuer) with piecemeal necrosis and portal=portal bridging. The patient received 1mg EB every one or two weeks. Estradiol treatment was followed by return toward normal values of ALP and γ-GTP. Histology obtained at 16 and 33 months of treatment showed disappearance of piecemeal necrosis and portal=portal bridging, respectively. No remarkable side effect was observed in the course of treatment. The observation suggests that EB has a salutary effect on PBC.
doi_str_mv	10.2957/kanzo.29.1638
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This 35-year-old female was admitted to the Kitasato University Hospital complaining of general fatigue. The liver function tests showed a mild elevation of bilirubin, accompained by an elevation of transaminase, alkaline phosphatase (ALP) and γ-glutamyltranspeptitase (γ-GTP) levels. Serum immnoglobulines of all three major classes were elevated, but elevation of IgM was most conspicuous with the degree of 395mg/100ml. Also demonstrated was positive test for anti-mitochondrial antibody. Biopsy of the liver disclosed PBC (stage 2-3 of Scheuer) with piecemeal necrosis and portal=portal bridging. The patient received 1mg EB every one or two weeks. Estradiol treatment was followed by return toward normal values of ALP and γ-GTP. Histology obtained at 16 and 33 months of treatment showed disappearance of piecemeal necrosis and portal=portal bridging, respectively. No remarkable side effect was observed in the course of treatment. The observation suggests that EB has a salutary effect on PBC.</description><identifier>ISSN: 0451-4203</identifier><identifier>EISSN: 1881-3593</identifier><identifier>DOI: 10.2957/kanzo.29.1638</identifier><language>eng ; jpn</language><publisher>The Japan Society of Hepatology</publisher><subject>PBC</subject><ispartof>Kanzo, 1988/12/25, Vol.29(12), pp.1638-1642</ispartof><rights>The Japan Society of Hepatology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,4025,27928,27929,27930</link.rule.ids></links><search><creatorcontrib>MATSUKI, Shigeki</creatorcontrib><creatorcontrib>ISHII, Kohdoh</creatorcontrib><creatorcontrib>SHIRASAKI, Keiji</creatorcontrib><creatorcontrib>SUGIMOTO, Masanao</creatorcontrib><creatorcontrib>NII, Shigenori</creatorcontrib><creatorcontrib>KARUBE, Hitomi</creatorcontrib><creatorcontrib>KOKUBU, Shigehiro</creatorcontrib><creatorcontrib>YAMADA, Nobuo</creatorcontrib><creatorcontrib>SHIBATA, Hisao</creatorcontrib><creatorcontrib>OKABE, Haruya</creatorcontrib><creatorcontrib>OHBU, Makoto</creatorcontrib><creatorcontrib>OKUDAIRA, Masahiko</creatorcontrib><title>Therapeutic effect of estradiol benzoate on primary biliary cirrhosis -A case report</title><title>Kanzo</title><addtitle>Kanzo</addtitle><description>A case of asynptomatic primary biliary cirrhosis (a-PBC) succesfully treated with estradiol benzoate (EB) was reported. This 35-year-old female was admitted to the Kitasato University Hospital complaining of general fatigue. The liver function tests showed a mild elevation of bilirubin, accompained by an elevation of transaminase, alkaline phosphatase (ALP) and γ-glutamyltranspeptitase (γ-GTP) levels. Serum immnoglobulines of all three major classes were elevated, but elevation of IgM was most conspicuous with the degree of 395mg/100ml. Also demonstrated was positive test for anti-mitochondrial antibody. Biopsy of the liver disclosed PBC (stage 2-3 of Scheuer) with piecemeal necrosis and portal=portal bridging. The patient received 1mg EB every one or two weeks. Estradiol treatment was followed by return toward normal values of ALP and γ-GTP. Histology obtained at 16 and 33 months of treatment showed disappearance of piecemeal necrosis and portal=portal bridging, respectively. No remarkable side effect was observed in the course of treatment. 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This 35-year-old female was admitted to the Kitasato University Hospital complaining of general fatigue. The liver function tests showed a mild elevation of bilirubin, accompained by an elevation of transaminase, alkaline phosphatase (ALP) and γ-glutamyltranspeptitase (γ-GTP) levels. Serum immnoglobulines of all three major classes were elevated, but elevation of IgM was most conspicuous with the degree of 395mg/100ml. Also demonstrated was positive test for anti-mitochondrial antibody. Biopsy of the liver disclosed PBC (stage 2-3 of Scheuer) with piecemeal necrosis and portal=portal bridging. The patient received 1mg EB every one or two weeks. Estradiol treatment was followed by return toward normal values of ALP and γ-GTP. Histology obtained at 16 and 33 months of treatment showed disappearance of piecemeal necrosis and portal=portal bridging, respectively. No remarkable side effect was observed in the course of treatment. The observation suggests that EB has a salutary effect on PBC.</abstract><pub>The Japan Society of Hepatology</pub><doi>10.2957/kanzo.29.1638</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects	PBC
title	Therapeutic effect of estradiol benzoate on primary biliary cirrhosis -A case report
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