A case of lupoid hepatitis observed from acute hepatitis to hepatocellular carcinoma for 7 years

A case of lupoid hepatitis whose initial symptom was of acute hepatitis and complicated heaptocellular carcinoma 7 yars later of protracted disease A case of lupoid hepatitis whose initial symptom was of acute hepatitis and complicated heaptocellular carcinoma 7 yars later of protracted disease course was described. The patient developed jaundice at the age of 16 and clinical evidence i.e. hypergammaglobulinemia (2.8g/dl), positive LE cells, ANF, SMA, remission by steroid therapy, supported the diagnosis of lupoid hepatitis. Continued observations by peritoneoscopy and needle liver biopsy have been made throughout the entire course. Acute inflammatory change characterized by bridging necrosis, gradually proceeded to chronic active hepatitis with lobular reconstruction and to macronodular liver cirrhosis type. 7 years after onset and 2 years later of liver cirrhosis type progressed, hepatocellular carcinoma developed and several therapeutic trials were without success and the patient succumbed to liver insufficiency at the age of 25. HBV markers have been negative throughout the course of the disease.