Rapid infusion of a phospholipid emulsion attenuates the effects of endotoxaemia in horses

Summary Reasons for performing study: Endotoxaemia currently is associated with a poor prognosis in horses. The results of recent trials in other species indicate that phospholipid emulsions reduce the deleterious effects of endotoxin (LPS). However, in a previous study in horses, a 2 h infusion of...

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Veröffentlicht in:	Equine veterinary journal 2007-05, Vol.39 (3), p.243-248
Hauptverfasser:	Moore, J.N, Norton, N, Barton, M.H, Hurley, D.J, Reber, A.J, Donovan, D.C, Vandenplas, M.L, Parker, T.S, Levine, D.M
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects Animals Area Under Curve Body Temperature - drug effects disease severity dosage dose response Dose-Response Relationship, Drug emulsion emulsions endotoxaemia endotoxemia Endotoxemia - therapy Endotoxemia - veterinary endotoxins Fat Emulsions, Intravenous - adverse effects Fat Emulsions, Intravenous - therapeutic use Female Heart Rate - drug effects hemolysis Hemolysis - drug effects horse horse diseases Horse Diseases - chemically induced Horse Diseases - therapy Horses in vitro culture in vivo studies inflammation infusions Infusions, Intravenous - veterinary intravenous injection Kinetics lipopolysaccharides Male phospholipid phospholipids Phospholipids - adverse effects Phospholipids - therapeutic use protective effect Severity of Illness Index Time Factors treatment Treatment Outcome tumor necrosis factors
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