Experimental study of activated carbon adsorbed aclarubicin
For anticancer effects on metastatic lymph node, activated carbon adsorbed anticancer drugs were injected preoperatively into the present study, the adsorption isotherm of activated carbon adsorbed aclarubicin (ACR) was measured and its stability in solution was investigated. The adsorption isotherm...
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| Veröffentlicht in: | Drug Delivery System 1989/04/10, Vol.4(2), pp.71-73 |
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| container_end_page | 73 |
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| container_issue | 2 |
| container_start_page | 71 |
| container_title | Drug Delivery System |
| container_volume | 4 |
| creator | Kobayashi, Osamu Takatani, Ikuo Makino, Tatsuro Sairenji, Motonori Motohashi, Hisahiho Sugimasa, Yukio Takemiya, Shoji Okamoto, Takashi Asaga, Taro Masuzawa, Chihiro Tamai, Setsuo Iimori, Kazuto Murakami, Kenji |
| description | For anticancer effects on metastatic lymph node, activated carbon adsorbed anticancer drugs were injected preoperatively into the present study, the adsorption isotherm of activated carbon adsorbed aclarubicin (ACR) was measured and its stability in solution was investigated. The adsorption isotherms of 5-FU and MMC were prepared and compared with that of aclarubicin. In the adsorption isotherm of CH-40 activated carbon, the amount of ACR adsorbed was better than that of 5-FU and MMC. The amount of ACR adsorbed for CH-1500 activated carbon was also better than that for CH-40 activated carbon. The stability of ACR adsorbed on activated carbon solution decreased as the concentration of the activated carbon increased. The stability when the activated carbon and ACR concentration ratio was constant in saline solution was 100% after 2 hours and 40% after 7 days. |
| doi_str_mv | 10.2745/dds.4.71 |
| format | Article |
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The adsorption isotherms of 5-FU and MMC were prepared and compared with that of aclarubicin. In the adsorption isotherm of CH-40 activated carbon, the amount of ACR adsorbed was better than that of 5-FU and MMC. The amount of ACR adsorbed for CH-1500 activated carbon was also better than that for CH-40 activated carbon. The stability of ACR adsorbed on activated carbon solution decreased as the concentration of the activated carbon increased. 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The adsorption isotherms of 5-FU and MMC were prepared and compared with that of aclarubicin. In the adsorption isotherm of CH-40 activated carbon, the amount of ACR adsorbed was better than that of 5-FU and MMC. The amount of ACR adsorbed for CH-1500 activated carbon was also better than that for CH-40 activated carbon. The stability of ACR adsorbed on activated carbon solution decreased as the concentration of the activated carbon increased. 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| ispartof | Drug Delivery System, 1989/04/10, Vol.4(2), pp.71-73 |
| issn | 0913-5006 1881-2732 |
| language | eng ; jpn |
| recordid | cdi_crossref_primary_10_2745_dds_4_71 |
| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | ACR activated carbon gastric cancer |
| title | Experimental study of activated carbon adsorbed aclarubicin |
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