A novel device to prevent osteoporosis by promoting bone metabolism using a newly developed double-loading stimulation with vibration and shaking
In Japan, 13 million people have osteoporosis, including approximately 9 hundred thousand people who are bedridden owing to bone fractures from falls. Preventing osteoporosis is considered to be an important and effective way of preventing fall-related fractures. Thus, we developed a novel method of...
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| Veröffentlicht in: | Okajimas Folia Anatomica Japonica 2019, Vol.96(1), pp.13-21 |
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| creator | YAO, Runhong NISHII, Kazuhiro KITO, Takumi TERANISHI, Toshio SUGIYAMA, Tomohisa SAKAI, Kazuyoshi MATSUBARA, Mamoru YAMADA, Kouji |
| description | In Japan, 13 million people have osteoporosis, including approximately 9 hundred thousand people who are bedridden owing to bone fractures from falls. Preventing osteoporosis is considered to be an important and effective way of preventing fall-related fractures. Thus, we developed a novel method of locomotor stimulation and analyzed its effectiveness in mice. Specifically, we created a double-loading device that combines vibration and shaking stimulation. The device was used to continuously stimulate ovariectomy-induced decreased bone density mouse models 30 minutes daily for 10 weeks. We then collected femur samples, created undecalcified tissue slices, calculated parameters using bone histomorphomtry, and conducted comparative testing. BS/TV (bone surface/tissue volume), N.Oc/ES (osteoclast number/eroded surface), Oc.S/ES (osteoclast osteoid surface/eroded surface), Omt (osteoid maturation time), Tb.N (trabecular number), Mlt (mineralization lag time) < (p < 0.01), N.Ob (osteoblast number), N.Ob/TV (osteoblast number/tissue volume), sLS (single labeled suface), N.Mu.Oc/ES (multinucle osteoclast number/eroded surface), and N.Mo.Oc/ES (mononucle osteoclast number/eroded surface) (p < 0.05) were significantly higher in the stimulation group than in the non-stimulation group. In addition, BS/BV (bone surface/bone volume), Tb.Sp (trabecular separation), MAR (mineral apposition rate), Aj.Ar (adjusted apposition rate) (p < 0.01), ES (eroded surface ), ES/BS (eroded surface/bone surface), and BRs.R (bone resorption rate) (p < 0.05) were significantly lower in the stimulation group than in the non-stimulation group. These results suggest that stimulation activated osteoblasts and osteoclasts, thereby leading to highly active bone remodeling. We anticipate that bone mineralization will subsequently occur, suggesting that this stimulation technique is effective in preventing osteoporosis by alleviating sudden bone density loss. |
| doi_str_mv | 10.2535/ofaj.96.13 |
| format | Article |
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Preventing osteoporosis is considered to be an important and effective way of preventing fall-related fractures. Thus, we developed a novel method of locomotor stimulation and analyzed its effectiveness in mice. Specifically, we created a double-loading device that combines vibration and shaking stimulation. The device was used to continuously stimulate ovariectomy-induced decreased bone density mouse models 30 minutes daily for 10 weeks. We then collected femur samples, created undecalcified tissue slices, calculated parameters using bone histomorphomtry, and conducted comparative testing. BS/TV (bone surface/tissue volume), N.Oc/ES (osteoclast number/eroded surface), Oc.S/ES (osteoclast osteoid surface/eroded surface), Omt (osteoid maturation time), Tb.N (trabecular number), Mlt (mineralization lag time) < (p < 0.01), N.Ob (osteoblast number), N.Ob/TV (osteoblast number/tissue volume), sLS (single labeled suface), N.Mu.Oc/ES (multinucle osteoclast number/eroded surface), and N.Mo.Oc/ES (mononucle osteoclast number/eroded surface) (p < 0.05) were significantly higher in the stimulation group than in the non-stimulation group. In addition, BS/BV (bone surface/bone volume), Tb.Sp (trabecular separation), MAR (mineral apposition rate), Aj.Ar (adjusted apposition rate) (p < 0.01), ES (eroded surface ), ES/BS (eroded surface/bone surface), and BRs.R (bone resorption rate) (p < 0.05) were significantly lower in the stimulation group than in the non-stimulation group. These results suggest that stimulation activated osteoblasts and osteoclasts, thereby leading to highly active bone remodeling. We anticipate that bone mineralization will subsequently occur, suggesting that this stimulation technique is effective in preventing osteoporosis by alleviating sudden bone density loss.</description><identifier>ISSN: 0030-154X</identifier><identifier>EISSN: 1881-1736</identifier><identifier>DOI: 10.2535/ofaj.96.13</identifier><identifier>PMID: 31462620</identifier><language>eng</language><publisher>Japan: Editorial Board of Okajimas Folia Anatomica Japonica</publisher><subject>Animals ; Bone and Bones - metabolism ; Bone mineral density ; Female ; Mice, Inbred ICR ; Osteoporosis ; Osteoporosis - prevention & control ; Postmenopausal women ; Prevention ; Vibration ; Vibration and shaking</subject><ispartof>Okajimas Folia Anatomica Japonica, 2019, Vol.96(1), pp.13-21</ispartof><rights>2019 Editorial Board of Okajimas Folia Anatomica Japonica</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3123-2173a498c5afc0db474d42c6d13cff709b5408c96732502f7954ba14a58cc9b63</citedby><cites>FETCH-LOGICAL-c3123-2173a498c5afc0db474d42c6d13cff709b5408c96732502f7954ba14a58cc9b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31462620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YAO, Runhong</creatorcontrib><creatorcontrib>NISHII, Kazuhiro</creatorcontrib><creatorcontrib>KITO, Takumi</creatorcontrib><creatorcontrib>TERANISHI, Toshio</creatorcontrib><creatorcontrib>SUGIYAMA, Tomohisa</creatorcontrib><creatorcontrib>SAKAI, Kazuyoshi</creatorcontrib><creatorcontrib>MATSUBARA, Mamoru</creatorcontrib><creatorcontrib>YAMADA, Kouji</creatorcontrib><title>A novel device to prevent osteoporosis by promoting bone metabolism using a newly developed double-loading stimulation with vibration and shaking</title><title>Okajimas Folia Anatomica Japonica</title><addtitle>Okajimas Folia Anat. Jpn.</addtitle><description>In Japan, 13 million people have osteoporosis, including approximately 9 hundred thousand people who are bedridden owing to bone fractures from falls. Preventing osteoporosis is considered to be an important and effective way of preventing fall-related fractures. Thus, we developed a novel method of locomotor stimulation and analyzed its effectiveness in mice. Specifically, we created a double-loading device that combines vibration and shaking stimulation. The device was used to continuously stimulate ovariectomy-induced decreased bone density mouse models 30 minutes daily for 10 weeks. We then collected femur samples, created undecalcified tissue slices, calculated parameters using bone histomorphomtry, and conducted comparative testing. BS/TV (bone surface/tissue volume), N.Oc/ES (osteoclast number/eroded surface), Oc.S/ES (osteoclast osteoid surface/eroded surface), Omt (osteoid maturation time), Tb.N (trabecular number), Mlt (mineralization lag time) < (p < 0.01), N.Ob (osteoblast number), N.Ob/TV (osteoblast number/tissue volume), sLS (single labeled suface), N.Mu.Oc/ES (multinucle osteoclast number/eroded surface), and N.Mo.Oc/ES (mononucle osteoclast number/eroded surface) (p < 0.05) were significantly higher in the stimulation group than in the non-stimulation group. In addition, BS/BV (bone surface/bone volume), Tb.Sp (trabecular separation), MAR (mineral apposition rate), Aj.Ar (adjusted apposition rate) (p < 0.01), ES (eroded surface ), ES/BS (eroded surface/bone surface), and BRs.R (bone resorption rate) (p < 0.05) were significantly lower in the stimulation group than in the non-stimulation group. These results suggest that stimulation activated osteoblasts and osteoclasts, thereby leading to highly active bone remodeling. We anticipate that bone mineralization will subsequently occur, suggesting that this stimulation technique is effective in preventing osteoporosis by alleviating sudden bone density loss.</description><subject>Animals</subject><subject>Bone and Bones - metabolism</subject><subject>Bone mineral density</subject><subject>Female</subject><subject>Mice, Inbred ICR</subject><subject>Osteoporosis</subject><subject>Osteoporosis - prevention & control</subject><subject>Postmenopausal women</subject><subject>Prevention</subject><subject>Vibration</subject><subject>Vibration and shaking</subject><issn>0030-154X</issn><issn>1881-1736</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMlKxEAURQtRtFE3foDUWkhbY4aFCxEnENwouAs1vNillVRIVbf0Z_jHJkTb1eNdDgfuReiMkiWTXF6GRn0sq3xJ-R5a0LKkGS14vo8WhHCSUSnejtBpjE4TwkQpJK0O0RGnImc5Iwv0fY27sAGPLWycAZwC7gfYQJdwiAlCH4YQXcR6O-ahDcl171iHDnALSengXWzxOk6pwh18-e1kAh96sNiGtfaQ-aDsBMTk2rVXyYUOf7m0whunh_lVncVxpT5H7AQdNMpHOP29x-j17vbl5iF7er5_vLl-ygynjGdsrKlEVRqpGkOsFoWwgpncUm6apiCVloKUpsoLziRhTVFJoRUVSpbGVDrnx-hi9pqxYRygqfvBtWrY1pTU07T1NG1d5TXlI3w-w_1at2B36N-QI3A1Ax8xqXfYAWpIznj4d83CXW5Waqih4z9B2I7z</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>YAO, Runhong</creator><creator>NISHII, Kazuhiro</creator><creator>KITO, Takumi</creator><creator>TERANISHI, Toshio</creator><creator>SUGIYAMA, Tomohisa</creator><creator>SAKAI, Kazuyoshi</creator><creator>MATSUBARA, Mamoru</creator><creator>YAMADA, Kouji</creator><general>Editorial Board of Okajimas Folia Anatomica Japonica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2019</creationdate><title>A novel device to prevent osteoporosis by promoting bone metabolism using a newly developed double-loading stimulation with vibration and shaking</title><author>YAO, Runhong ; NISHII, Kazuhiro ; KITO, Takumi ; TERANISHI, Toshio ; SUGIYAMA, Tomohisa ; SAKAI, Kazuyoshi ; MATSUBARA, Mamoru ; YAMADA, Kouji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3123-2173a498c5afc0db474d42c6d13cff709b5408c96732502f7954ba14a58cc9b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Bone and Bones - metabolism</topic><topic>Bone mineral density</topic><topic>Female</topic><topic>Mice, Inbred ICR</topic><topic>Osteoporosis</topic><topic>Osteoporosis - prevention & control</topic><topic>Postmenopausal women</topic><topic>Prevention</topic><topic>Vibration</topic><topic>Vibration and shaking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YAO, Runhong</creatorcontrib><creatorcontrib>NISHII, Kazuhiro</creatorcontrib><creatorcontrib>KITO, Takumi</creatorcontrib><creatorcontrib>TERANISHI, Toshio</creatorcontrib><creatorcontrib>SUGIYAMA, Tomohisa</creatorcontrib><creatorcontrib>SAKAI, Kazuyoshi</creatorcontrib><creatorcontrib>MATSUBARA, Mamoru</creatorcontrib><creatorcontrib>YAMADA, Kouji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Okajimas Folia Anatomica Japonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAO, Runhong</au><au>NISHII, Kazuhiro</au><au>KITO, Takumi</au><au>TERANISHI, Toshio</au><au>SUGIYAMA, Tomohisa</au><au>SAKAI, Kazuyoshi</au><au>MATSUBARA, Mamoru</au><au>YAMADA, Kouji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel device to prevent osteoporosis by promoting bone metabolism using a newly developed double-loading stimulation with vibration and shaking</atitle><jtitle>Okajimas Folia Anatomica Japonica</jtitle><addtitle>Okajimas Folia Anat. Jpn.</addtitle><date>2019</date><risdate>2019</risdate><volume>96</volume><issue>1</issue><spage>13</spage><epage>21</epage><pages>13-21</pages><issn>0030-154X</issn><eissn>1881-1736</eissn><abstract>In Japan, 13 million people have osteoporosis, including approximately 9 hundred thousand people who are bedridden owing to bone fractures from falls. Preventing osteoporosis is considered to be an important and effective way of preventing fall-related fractures. Thus, we developed a novel method of locomotor stimulation and analyzed its effectiveness in mice. Specifically, we created a double-loading device that combines vibration and shaking stimulation. The device was used to continuously stimulate ovariectomy-induced decreased bone density mouse models 30 minutes daily for 10 weeks. We then collected femur samples, created undecalcified tissue slices, calculated parameters using bone histomorphomtry, and conducted comparative testing. BS/TV (bone surface/tissue volume), N.Oc/ES (osteoclast number/eroded surface), Oc.S/ES (osteoclast osteoid surface/eroded surface), Omt (osteoid maturation time), Tb.N (trabecular number), Mlt (mineralization lag time) < (p < 0.01), N.Ob (osteoblast number), N.Ob/TV (osteoblast number/tissue volume), sLS (single labeled suface), N.Mu.Oc/ES (multinucle osteoclast number/eroded surface), and N.Mo.Oc/ES (mononucle osteoclast number/eroded surface) (p < 0.05) were significantly higher in the stimulation group than in the non-stimulation group. In addition, BS/BV (bone surface/bone volume), Tb.Sp (trabecular separation), MAR (mineral apposition rate), Aj.Ar (adjusted apposition rate) (p < 0.01), ES (eroded surface ), ES/BS (eroded surface/bone surface), and BRs.R (bone resorption rate) (p < 0.05) were significantly lower in the stimulation group than in the non-stimulation group. These results suggest that stimulation activated osteoblasts and osteoclasts, thereby leading to highly active bone remodeling. We anticipate that bone mineralization will subsequently occur, suggesting that this stimulation technique is effective in preventing osteoporosis by alleviating sudden bone density loss.</abstract><cop>Japan</cop><pub>Editorial Board of Okajimas Folia Anatomica Japonica</pub><pmid>31462620</pmid><doi>10.2535/ofaj.96.13</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Bone and Bones - metabolism Bone mineral density Female Mice, Inbred ICR Osteoporosis Osteoporosis - prevention & control Postmenopausal women Prevention Vibration Vibration and shaking |
| title | A novel device to prevent osteoporosis by promoting bone metabolism using a newly developed double-loading stimulation with vibration and shaking |
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