Relationship of HLA-DRB1 Alleles and Rheumatoid Arthritis in West South of Iran
Background: Rheumatoid arthritis is a systemic multifactor disease that presented with symmetrical polyarthritis more preferably in small wrist joint and ankle. Synovial pannus cause destruction and deformities in joints. The main reason of this disease in unknown, but past researchesshowed that gen...
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| Veröffentlicht in: | INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH 2017-07, Vol.9 (3) |
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| container_title | INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH |
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| creator | Mowla, Karim M. D., Elham Rajaee M. D., Mehrdad Dargahi-MalAmir Yousefinezhad, Neda Hondori, Maryam Jamali |
| description | Background: Rheumatoid arthritis is a systemic multifactor disease that presented with symmetrical polyarthritis more
preferably in small wrist joint and ankle. Synovial pannus cause destruction and deformities in joints. The main reason of
this disease in unknown, but past researchesshowed that genetically factor play important role beside environmental factors
in susceptibility to this entity. Method:100 patients with rheumatoid arthritis diagnosed upon ACR 2010 criteria enrolled
study. 92 healthy patents also enrolled DNA studying. of both group was extracted through DNA extraction kits by blood
sampling. HLA-DRB1 typing was done by PCR-SSP method. Results: There were no significant differences in HLADRB1
*04, HLADRB1*08 and HLADRB1*11 alleles presentation between patients and healthy controls. Only there were
statically significant correlation between HLA-DRB1*08 and Rheumatoid factor positive patents. (P = 0.025). |
| doi_str_mv | 10.25258/ijtpr.v9i03.9073 |
| format | Article |
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preferably in small wrist joint and ankle. Synovial pannus cause destruction and deformities in joints. The main reason of
this disease in unknown, but past researchesshowed that genetically factor play important role beside environmental factors
in susceptibility to this entity. Method:100 patients with rheumatoid arthritis diagnosed upon ACR 2010 criteria enrolled
study. 92 healthy patents also enrolled DNA studying. of both group was extracted through DNA extraction kits by blood
sampling. HLA-DRB1 typing was done by PCR-SSP method. Results: There were no significant differences in HLADRB1
*04, HLADRB1*08 and HLADRB1*11 alleles presentation between patients and healthy controls. Only there were
statically significant correlation between HLA-DRB1*08 and Rheumatoid factor positive patents. (P = 0.025).</description><identifier>ISSN: 0975-5160</identifier><identifier>EISSN: 0975-5160</identifier><identifier>DOI: 10.25258/ijtpr.v9i03.9073</identifier><language>eng</language><ispartof>INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH, 2017-07, Vol.9 (3)</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Mowla, Karim</creatorcontrib><creatorcontrib>M. D., Elham Rajaee</creatorcontrib><creatorcontrib>M. D., Mehrdad Dargahi-MalAmir</creatorcontrib><creatorcontrib>Yousefinezhad, Neda</creatorcontrib><creatorcontrib>Hondori, Maryam Jamali</creatorcontrib><title>Relationship of HLA-DRB1 Alleles and Rheumatoid Arthritis in West South of Iran</title><title>INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH</title><description>Background: Rheumatoid arthritis is a systemic multifactor disease that presented with symmetrical polyarthritis more
preferably in small wrist joint and ankle. Synovial pannus cause destruction and deformities in joints. The main reason of
this disease in unknown, but past researchesshowed that genetically factor play important role beside environmental factors
in susceptibility to this entity. Method:100 patients with rheumatoid arthritis diagnosed upon ACR 2010 criteria enrolled
study. 92 healthy patents also enrolled DNA studying. of both group was extracted through DNA extraction kits by blood
sampling. HLA-DRB1 typing was done by PCR-SSP method. Results: There were no significant differences in HLADRB1
*04, HLADRB1*08 and HLADRB1*11 alleles presentation between patients and healthy controls. Only there were
statically significant correlation between HLA-DRB1*08 and Rheumatoid factor positive patents. (P = 0.025).</description><issn>0975-5160</issn><issn>0975-5160</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqdzsGKwjAUheEgM6CoD-DuvkBrYkltl3VGURCEOjDLkLEpvRKbkhsF314sLlzP6pzNDx9jM8HjhVzIbI7n0Pn4liNP4pwvkwEb8XwpIylS_vH2h2xKhH9c5DLNRJaM2KE0Vgd0LTXYgathuy-i73IloLDWWEOg2wrKxlwvOjisoPCh8RiQAFv4NRTg6K6heaY7r9sJ-6y1JTN97ZiJzfrnaxudvCPypladx4v2dyW46vGqx6ser5745D_NA0A2T4Y</recordid><startdate>20170725</startdate><enddate>20170725</enddate><creator>Mowla, Karim</creator><creator>M. D., Elham Rajaee</creator><creator>M. D., Mehrdad Dargahi-MalAmir</creator><creator>Yousefinezhad, Neda</creator><creator>Hondori, Maryam Jamali</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20170725</creationdate><title>Relationship of HLA-DRB1 Alleles and Rheumatoid Arthritis in West South of Iran</title><author>Mowla, Karim ; M. D., Elham Rajaee ; M. D., Mehrdad Dargahi-MalAmir ; Yousefinezhad, Neda ; Hondori, Maryam Jamali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-crossref_primary_10_25258_ijtpr_v9i03_90733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Mowla, Karim</creatorcontrib><creatorcontrib>M. D., Elham Rajaee</creatorcontrib><creatorcontrib>M. D., Mehrdad Dargahi-MalAmir</creatorcontrib><creatorcontrib>Yousefinezhad, Neda</creatorcontrib><creatorcontrib>Hondori, Maryam Jamali</creatorcontrib><collection>CrossRef</collection><jtitle>INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mowla, Karim</au><au>M. D., Elham Rajaee</au><au>M. D., Mehrdad Dargahi-MalAmir</au><au>Yousefinezhad, Neda</au><au>Hondori, Maryam Jamali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of HLA-DRB1 Alleles and Rheumatoid Arthritis in West South of Iran</atitle><jtitle>INTERNATIONAL JOURNAL OF TOXICOLOGICAL AND PHARMACOLOGICAL RESEARCH</jtitle><date>2017-07-25</date><risdate>2017</risdate><volume>9</volume><issue>3</issue><issn>0975-5160</issn><eissn>0975-5160</eissn><abstract>Background: Rheumatoid arthritis is a systemic multifactor disease that presented with symmetrical polyarthritis more
preferably in small wrist joint and ankle. Synovial pannus cause destruction and deformities in joints. The main reason of
this disease in unknown, but past researchesshowed that genetically factor play important role beside environmental factors
in susceptibility to this entity. Method:100 patients with rheumatoid arthritis diagnosed upon ACR 2010 criteria enrolled
study. 92 healthy patents also enrolled DNA studying. of both group was extracted through DNA extraction kits by blood
sampling. HLA-DRB1 typing was done by PCR-SSP method. Results: There were no significant differences in HLADRB1
*04, HLADRB1*08 and HLADRB1*11 alleles presentation between patients and healthy controls. Only there were
statically significant correlation between HLA-DRB1*08 and Rheumatoid factor positive patents. (P = 0.025).</abstract><doi>10.25258/ijtpr.v9i03.9073</doi></addata></record> |
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| source | EZB-FREE-00999 freely available EZB journals |
| title | Relationship of HLA-DRB1 Alleles and Rheumatoid Arthritis in West South of Iran |
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