Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis
Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs’ levels in...
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| Veröffentlicht in: | Industrial Health 2012, Vol.50(4), pp.299-306 |
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| creator | PELCLOVÁ, Daniela FENCLOVÁ, Zdenka VLCKOVÁ, Štepánka LEBEDOVÁ, Jindriška SYSLOVÁ, Kamila PECHA, Ondrej BELÁCEK, Jaromír NAVRÁTIL, Tomáš KUZMA, Marek KACER, Petr |
| description | Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs’ levels in the plasma and urine were measured in patients with pneumoconiosis (45 × asbestos exposure, 37 × silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid chromatography – electrospray ionization – tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT D4 and LT E4 were increased in both groups of patients (p |
| doi_str_mv | 10.2486/indhealth.MS1274 |
| format | Article |
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However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs’ levels in the plasma and urine were measured in patients with pneumoconiosis (45 × asbestos exposure, 37 × silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid chromatography – electrospray ionization – tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT D4 and LT E4 were increased in both groups of patients (p<0.001 and p<0.05), comparing with the controls. Both LT B4 and cysteinyl LTs were elevated in asbestos-exposed subjects (p<0.05). Asbestosis with more severe radiological signs (s1/s2–t3/u2) and lung functions impairment has shown higher cysteinyl LTs and LT C4 in the EBC (p<0.05) than mild asbestosis (s1/s0–s1/s1). In addition, in the subjects with asbestosis, cysteinyl LTs in EBC correlated with TLC (–0.313, p<0.05) and TLCO/Hb (–0.307, p<0.05), and LT C4 with TLC (–0.358, p<0.05). In pneumoconioses, EBC appears the most useful from the 3 fluids studied.]]></description><identifier>ISSN: 0019-8366</identifier><identifier>EISSN: 1880-8026</identifier><identifier>DOI: 10.2486/indhealth.MS1274</identifier><identifier>PMID: 22785421</identifier><language>eng</language><publisher>Japan: National Institute of Occupational Safety and Health</publisher><subject>Aged ; Asbestosis ; Asbestosis - diagnostic imaging ; Asbestosis - metabolism ; Breath Tests ; Exhaled breath condensate ; Female ; Humans ; LC-ESI-MS/MS ; Leukotriene B4 - analysis ; Leukotriene B4 - blood ; Leukotriene B4 - urine ; Leukotriene C4 - analysis ; Leukotriene C4 - blood ; Leukotriene C4 - urine ; Leukotriene D4 - analysis ; Leukotriene D4 - blood ; Leukotriene D4 - urine ; Leukotriene E4 - analysis ; Leukotriene E4 - blood ; Leukotriene E4 - urine ; Leukotrienes ; Leukotrienes - analysis ; Leukotrienes - blood ; Leukotrienes - urine ; Lung fibrosis ; Male ; Middle Aged ; Plasma ; Radiography ; Respiratory Function Tests ; Severity of Illness Index ; Silicosis ; Silicosis - diagnostic imaging ; Silicosis - metabolism ; SPE ; Urine</subject><ispartof>Industrial Health, 2012, Vol.50(4), pp.299-306</ispartof><rights>2012 by National Institute of Occupational Safety and Health</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-52792f54eeb8e7de02e698fd8c5b3fd3eff068721d3e1397aa4cfa7cf97b66a23</citedby><cites>FETCH-LOGICAL-c461t-52792f54eeb8e7de02e698fd8c5b3fd3eff068721d3e1397aa4cfa7cf97b66a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22785421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PELCLOVÁ, Daniela</creatorcontrib><creatorcontrib>FENCLOVÁ, Zdenka</creatorcontrib><creatorcontrib>VLCKOVÁ, Štepánka</creatorcontrib><creatorcontrib>LEBEDOVÁ, Jindriška</creatorcontrib><creatorcontrib>SYSLOVÁ, Kamila</creatorcontrib><creatorcontrib>PECHA, Ondrej</creatorcontrib><creatorcontrib>BELÁCEK, Jaromír</creatorcontrib><creatorcontrib>NAVRÁTIL, Tomáš</creatorcontrib><creatorcontrib>KUZMA, Marek</creatorcontrib><creatorcontrib>KACER, Petr</creatorcontrib><title>Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis</title><title>Industrial Health</title><addtitle>Ind Health</addtitle><description><![CDATA[Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs’ levels in the plasma and urine were measured in patients with pneumoconiosis (45 × asbestos exposure, 37 × silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid chromatography – electrospray ionization – tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT D4 and LT E4 were increased in both groups of patients (p<0.001 and p<0.05), comparing with the controls. Both LT B4 and cysteinyl LTs were elevated in asbestos-exposed subjects (p<0.05). Asbestosis with more severe radiological signs (s1/s2–t3/u2) and lung functions impairment has shown higher cysteinyl LTs and LT C4 in the EBC (p<0.05) than mild asbestosis (s1/s0–s1/s1). In addition, in the subjects with asbestosis, cysteinyl LTs in EBC correlated with TLC (–0.313, p<0.05) and TLCO/Hb (–0.307, p<0.05), and LT C4 with TLC (–0.358, p<0.05). In pneumoconioses, EBC appears the most useful from the 3 fluids studied.]]></description><subject>Aged</subject><subject>Asbestosis</subject><subject>Asbestosis - diagnostic imaging</subject><subject>Asbestosis - metabolism</subject><subject>Breath Tests</subject><subject>Exhaled breath condensate</subject><subject>Female</subject><subject>Humans</subject><subject>LC-ESI-MS/MS</subject><subject>Leukotriene B4 - analysis</subject><subject>Leukotriene B4 - blood</subject><subject>Leukotriene B4 - urine</subject><subject>Leukotriene C4 - analysis</subject><subject>Leukotriene C4 - blood</subject><subject>Leukotriene C4 - urine</subject><subject>Leukotriene D4 - analysis</subject><subject>Leukotriene D4 - blood</subject><subject>Leukotriene D4 - urine</subject><subject>Leukotriene E4 - analysis</subject><subject>Leukotriene E4 - blood</subject><subject>Leukotriene E4 - urine</subject><subject>Leukotrienes</subject><subject>Leukotrienes - analysis</subject><subject>Leukotrienes - blood</subject><subject>Leukotrienes - urine</subject><subject>Lung fibrosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plasma</subject><subject>Radiography</subject><subject>Respiratory Function Tests</subject><subject>Severity of Illness Index</subject><subject>Silicosis</subject><subject>Silicosis - diagnostic imaging</subject><subject>Silicosis - metabolism</subject><subject>SPE</subject><subject>Urine</subject><issn>0019-8366</issn><issn>1880-8026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAURi0EgvLYmZBHkBqwHcdxRhrKQyoCCZgjN74mhtRBtsvj35MSqBjuY_jOGT6EDik5ZVyKM-t0A6qNzentA2U530AjKiVJJGFiE40IoUUiUyF20G4IL4SkIivSbbTDWC4zzugIvc9g-dpFb8FBwBM-xmU_Fxwrp_GUY-twbABPPxvVgsYTDyo2uOycBhdUBHw8nZQnYzxpu07_QE_eOlhx9yr21hjwh-2RewfLRVd3znbBhn20ZVQb4OD37qGny-ljeZ3M7q5uyvNZUnNBY5KxvGAm4wBzCbkGwkAU0mhZZ_PU6BSMIULmjPYvTYtcKV4bldemyOdCKJbuITJ4a9-F4MFUb94ulP-qKKlWFVbrCquhwh45GpC35XwBeg38ddYHLofAS4jqGdYB5aOtW_hnzEjFV2swrwN1o3wFLv0GKwGIQA</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>PELCLOVÁ, Daniela</creator><creator>FENCLOVÁ, Zdenka</creator><creator>VLCKOVÁ, Štepánka</creator><creator>LEBEDOVÁ, Jindriška</creator><creator>SYSLOVÁ, Kamila</creator><creator>PECHA, Ondrej</creator><creator>BELÁCEK, Jaromír</creator><creator>NAVRÁTIL, Tomáš</creator><creator>KUZMA, Marek</creator><creator>KACER, Petr</creator><general>National Institute of Occupational Safety and Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2012</creationdate><title>Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis</title><author>PELCLOVÁ, Daniela ; FENCLOVÁ, Zdenka ; VLCKOVÁ, Štepánka ; LEBEDOVÁ, Jindriška ; SYSLOVÁ, Kamila ; PECHA, Ondrej ; BELÁCEK, Jaromír ; NAVRÁTIL, Tomáš ; KUZMA, Marek ; KACER, Petr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-52792f54eeb8e7de02e698fd8c5b3fd3eff068721d3e1397aa4cfa7cf97b66a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Asbestosis</topic><topic>Asbestosis - diagnostic imaging</topic><topic>Asbestosis - metabolism</topic><topic>Breath Tests</topic><topic>Exhaled breath condensate</topic><topic>Female</topic><topic>Humans</topic><topic>LC-ESI-MS/MS</topic><topic>Leukotriene B4 - analysis</topic><topic>Leukotriene B4 - blood</topic><topic>Leukotriene B4 - urine</topic><topic>Leukotriene C4 - analysis</topic><topic>Leukotriene C4 - blood</topic><topic>Leukotriene C4 - urine</topic><topic>Leukotriene D4 - analysis</topic><topic>Leukotriene D4 - blood</topic><topic>Leukotriene D4 - urine</topic><topic>Leukotriene E4 - analysis</topic><topic>Leukotriene E4 - blood</topic><topic>Leukotriene E4 - urine</topic><topic>Leukotrienes</topic><topic>Leukotrienes - analysis</topic><topic>Leukotrienes - blood</topic><topic>Leukotrienes - urine</topic><topic>Lung fibrosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plasma</topic><topic>Radiography</topic><topic>Respiratory Function Tests</topic><topic>Severity of Illness Index</topic><topic>Silicosis</topic><topic>Silicosis - diagnostic imaging</topic><topic>Silicosis - metabolism</topic><topic>SPE</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PELCLOVÁ, Daniela</creatorcontrib><creatorcontrib>FENCLOVÁ, Zdenka</creatorcontrib><creatorcontrib>VLCKOVÁ, Štepánka</creatorcontrib><creatorcontrib>LEBEDOVÁ, Jindriška</creatorcontrib><creatorcontrib>SYSLOVÁ, Kamila</creatorcontrib><creatorcontrib>PECHA, Ondrej</creatorcontrib><creatorcontrib>BELÁCEK, Jaromír</creatorcontrib><creatorcontrib>NAVRÁTIL, Tomáš</creatorcontrib><creatorcontrib>KUZMA, Marek</creatorcontrib><creatorcontrib>KACER, Petr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Industrial Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PELCLOVÁ, Daniela</au><au>FENCLOVÁ, Zdenka</au><au>VLCKOVÁ, Štepánka</au><au>LEBEDOVÁ, Jindriška</au><au>SYSLOVÁ, Kamila</au><au>PECHA, Ondrej</au><au>BELÁCEK, Jaromír</au><au>NAVRÁTIL, Tomáš</au><au>KUZMA, Marek</au><au>KACER, Petr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis</atitle><jtitle>Industrial Health</jtitle><addtitle>Ind Health</addtitle><date>2012</date><risdate>2012</risdate><volume>50</volume><issue>4</issue><spage>299</spage><epage>306</epage><pages>299-306</pages><issn>0019-8366</issn><eissn>1880-8026</eissn><abstract><![CDATA[Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs’ levels in the plasma and urine were measured in patients with pneumoconiosis (45 × asbestos exposure, 37 × silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid chromatography – electrospray ionization – tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT D4 and LT E4 were increased in both groups of patients (p<0.001 and p<0.05), comparing with the controls. Both LT B4 and cysteinyl LTs were elevated in asbestos-exposed subjects (p<0.05). Asbestosis with more severe radiological signs (s1/s2–t3/u2) and lung functions impairment has shown higher cysteinyl LTs and LT C4 in the EBC (p<0.05) than mild asbestosis (s1/s0–s1/s1). In addition, in the subjects with asbestosis, cysteinyl LTs in EBC correlated with TLC (–0.313, p<0.05) and TLCO/Hb (–0.307, p<0.05), and LT C4 with TLC (–0.358, p<0.05). In pneumoconioses, EBC appears the most useful from the 3 fluids studied.]]></abstract><cop>Japan</cop><pub>National Institute of Occupational Safety and Health</pub><pmid>22785421</pmid><doi>10.2486/indhealth.MS1274</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0019-8366 |
| ispartof | Industrial Health, 2012, Vol.50(4), pp.299-306 |
| issn | 0019-8366 1880-8026 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Asbestosis Asbestosis - diagnostic imaging Asbestosis - metabolism Breath Tests Exhaled breath condensate Female Humans LC-ESI-MS/MS Leukotriene B4 - analysis Leukotriene B4 - blood Leukotriene B4 - urine Leukotriene C4 - analysis Leukotriene C4 - blood Leukotriene C4 - urine Leukotriene D4 - analysis Leukotriene D4 - blood Leukotriene D4 - urine Leukotriene E4 - analysis Leukotriene E4 - blood Leukotriene E4 - urine Leukotrienes Leukotrienes - analysis Leukotrienes - blood Leukotrienes - urine Lung fibrosis Male Middle Aged Plasma Radiography Respiratory Function Tests Severity of Illness Index Silicosis Silicosis - diagnostic imaging Silicosis - metabolism SPE Urine |
| title | Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis |
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