A Mouse Model of a Sudden Death Induced by Noise Exposure is Useful to Investigate Human Responses to Physical Stress
Stress has become an increasingly important occupational health matter in Japan. We found that noise exposure, 6kHz wave and its higher harmonics at the sound pressure level of 112dB, induced typical audiogenic seizures in the MRL/l mouse strain. The seizures are often fatal. Wild running preludes t...
Gespeichert in:
| Veröffentlicht in: | Industrial Health 1995, Vol.33(1), pp.29-33 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 33 |
|---|---|
| container_issue | 1 |
| container_start_page | 29 |
| container_title | Industrial Health |
| container_volume | 33 |
| creator | WADA, Yasuhiko MOGI, Takashi INOUE, Hiroshi KOIZUMI, Akio |
| description | Stress has become an increasingly important occupational health matter in Japan. We found that noise exposure, 6kHz wave and its higher harmonics at the sound pressure level of 112dB, induced typical audiogenic seizures in the MRL/l mouse strain. The seizures are often fatal. Wild running preludes to seizures. Inhibition of wild running by restricting animal's activities successfully prevented the seizures, suggesting that an excessive physical load is a necessary step. The present finding indicates that MRL/l mice may be a useful model for human sudden deaths after excessive work loads. |
| doi_str_mv | 10.2486/indhealth.33.29 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_2486_indhealth_33_29</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>7591858</sourcerecordid><originalsourceid>FETCH-LOGICAL-c550t-6039671ba6382e2ce1852b9aadc3b9105512ca97513e63765704df51445557ed3</originalsourceid><addsrcrecordid>eNpFkEtPwzAQhC0EglI4c0LyH0jrR-3ER8SrSLxE6Tly7A0JSpMo6yD670nVKlxmD9_MaDWEXHE2E4tEz8vaF2CrUMyknAlzRCY8SViUMKGPyYQxbqJEan1GzhG_GZNaGXlKTmNleKKSCelv6EvTIwzqoaJNTi1d9d5DTe_AhoI-1b534Gm2pa9NORjvf9sG-w5oiXSNkPcVDc1g-wEM5ZcNQJf9xtb0A7BtagTc4fdii6WzFV2FDhAvyEluK4TLw52S9cP95-0yen57fLq9eY6cUixEmkmjY55ZLRMBwsHws8iMtd7JzHCmFBfOmlhxCVrGWsVs4XPFFwulVAxeTsl83-u6BrGDPG27cmO7bcpZutsvHfdLpUyFGRLX-0TbZxvwo_8w2MCXe_6NwX7ByG0XSlfBfx83Wu46-V6EGS2usF0KtfwDaPeH0Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A Mouse Model of a Sudden Death Induced by Noise Exposure is Useful to Investigate Human Responses to Physical Stress</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>WADA, Yasuhiko ; MOGI, Takashi ; INOUE, Hiroshi ; KOIZUMI, Akio</creator><creatorcontrib>WADA, Yasuhiko ; MOGI, Takashi ; INOUE, Hiroshi ; KOIZUMI, Akio</creatorcontrib><description>Stress has become an increasingly important occupational health matter in Japan. We found that noise exposure, 6kHz wave and its higher harmonics at the sound pressure level of 112dB, induced typical audiogenic seizures in the MRL/l mouse strain. The seizures are often fatal. Wild running preludes to seizures. Inhibition of wild running by restricting animal's activities successfully prevented the seizures, suggesting that an excessive physical load is a necessary step. The present finding indicates that MRL/l mice may be a useful model for human sudden deaths after excessive work loads.</description><identifier>ISSN: 0019-8366</identifier><identifier>EISSN: 1880-8026</identifier><identifier>DOI: 10.2486/indhealth.33.29</identifier><identifier>PMID: 7591858</identifier><language>eng</language><publisher>Japan: National Institute of Occupational Safety and Health</publisher><subject>Acoustic Stimulation ; Animals ; Audiogenic seizure ; Death, Sudden - etiology ; Disease Models, Animal ; Excessive physical stress ; Japan ; Mice ; Mice, Inbred Strains ; MRL/l mice ; Noise, Occupational - adverse effects ; Restraint, Physical ; Seizures - etiology</subject><ispartof>Industrial Health, 1995, Vol.33(1), pp.29-33</ispartof><rights>National Institute of Occupational Safety and Health</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-6039671ba6382e2ce1852b9aadc3b9105512ca97513e63765704df51445557ed3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7591858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WADA, Yasuhiko</creatorcontrib><creatorcontrib>MOGI, Takashi</creatorcontrib><creatorcontrib>INOUE, Hiroshi</creatorcontrib><creatorcontrib>KOIZUMI, Akio</creatorcontrib><title>A Mouse Model of a Sudden Death Induced by Noise Exposure is Useful to Investigate Human Responses to Physical Stress</title><title>Industrial Health</title><addtitle>Ind Health</addtitle><description>Stress has become an increasingly important occupational health matter in Japan. We found that noise exposure, 6kHz wave and its higher harmonics at the sound pressure level of 112dB, induced typical audiogenic seizures in the MRL/l mouse strain. The seizures are often fatal. Wild running preludes to seizures. Inhibition of wild running by restricting animal's activities successfully prevented the seizures, suggesting that an excessive physical load is a necessary step. The present finding indicates that MRL/l mice may be a useful model for human sudden deaths after excessive work loads.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Audiogenic seizure</subject><subject>Death, Sudden - etiology</subject><subject>Disease Models, Animal</subject><subject>Excessive physical stress</subject><subject>Japan</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>MRL/l mice</subject><subject>Noise, Occupational - adverse effects</subject><subject>Restraint, Physical</subject><subject>Seizures - etiology</subject><issn>0019-8366</issn><issn>1880-8026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwzAQhC0EglI4c0LyH0jrR-3ER8SrSLxE6Tly7A0JSpMo6yD670nVKlxmD9_MaDWEXHE2E4tEz8vaF2CrUMyknAlzRCY8SViUMKGPyYQxbqJEan1GzhG_GZNaGXlKTmNleKKSCelv6EvTIwzqoaJNTi1d9d5DTe_AhoI-1b534Gm2pa9NORjvf9sG-w5oiXSNkPcVDc1g-wEM5ZcNQJf9xtb0A7BtagTc4fdii6WzFV2FDhAvyEluK4TLw52S9cP95-0yen57fLq9eY6cUixEmkmjY55ZLRMBwsHws8iMtd7JzHCmFBfOmlhxCVrGWsVs4XPFFwulVAxeTsl83-u6BrGDPG27cmO7bcpZutsvHfdLpUyFGRLX-0TbZxvwo_8w2MCXe_6NwX7ByG0XSlfBfx83Wu46-V6EGS2usF0KtfwDaPeH0Q</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>WADA, Yasuhiko</creator><creator>MOGI, Takashi</creator><creator>INOUE, Hiroshi</creator><creator>KOIZUMI, Akio</creator><general>National Institute of Occupational Safety and Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1995</creationdate><title>A Mouse Model of a Sudden Death Induced by Noise Exposure is Useful to Investigate Human Responses to Physical Stress</title><author>WADA, Yasuhiko ; MOGI, Takashi ; INOUE, Hiroshi ; KOIZUMI, Akio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-6039671ba6382e2ce1852b9aadc3b9105512ca97513e63765704df51445557ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Audiogenic seizure</topic><topic>Death, Sudden - etiology</topic><topic>Disease Models, Animal</topic><topic>Excessive physical stress</topic><topic>Japan</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>MRL/l mice</topic><topic>Noise, Occupational - adverse effects</topic><topic>Restraint, Physical</topic><topic>Seizures - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WADA, Yasuhiko</creatorcontrib><creatorcontrib>MOGI, Takashi</creatorcontrib><creatorcontrib>INOUE, Hiroshi</creatorcontrib><creatorcontrib>KOIZUMI, Akio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Industrial Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WADA, Yasuhiko</au><au>MOGI, Takashi</au><au>INOUE, Hiroshi</au><au>KOIZUMI, Akio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Mouse Model of a Sudden Death Induced by Noise Exposure is Useful to Investigate Human Responses to Physical Stress</atitle><jtitle>Industrial Health</jtitle><addtitle>Ind Health</addtitle><date>1995</date><risdate>1995</risdate><volume>33</volume><issue>1</issue><spage>29</spage><epage>33</epage><pages>29-33</pages><issn>0019-8366</issn><eissn>1880-8026</eissn><abstract>Stress has become an increasingly important occupational health matter in Japan. We found that noise exposure, 6kHz wave and its higher harmonics at the sound pressure level of 112dB, induced typical audiogenic seizures in the MRL/l mouse strain. The seizures are often fatal. Wild running preludes to seizures. Inhibition of wild running by restricting animal's activities successfully prevented the seizures, suggesting that an excessive physical load is a necessary step. The present finding indicates that MRL/l mice may be a useful model for human sudden deaths after excessive work loads.</abstract><cop>Japan</cop><pub>National Institute of Occupational Safety and Health</pub><pmid>7591858</pmid><doi>10.2486/indhealth.33.29</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-8366 |
| ispartof | Industrial Health, 1995, Vol.33(1), pp.29-33 |
| issn | 0019-8366 1880-8026 |
| language | eng |
| recordid | cdi_crossref_primary_10_2486_indhealth_33_29 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Acoustic Stimulation Animals Audiogenic seizure Death, Sudden - etiology Disease Models, Animal Excessive physical stress Japan Mice Mice, Inbred Strains MRL/l mice Noise, Occupational - adverse effects Restraint, Physical Seizures - etiology |
| title | A Mouse Model of a Sudden Death Induced by Noise Exposure is Useful to Investigate Human Responses to Physical Stress |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T01%3A10%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Mouse%20Model%20of%20a%20Sudden%20Death%20Induced%20by%20Noise%20Exposure%20is%20Useful%20to%20Investigate%20Human%20Responses%20to%20Physical%20Stress&rft.jtitle=Industrial%20Health&rft.au=WADA,%20Yasuhiko&rft.date=1995&rft.volume=33&rft.issue=1&rft.spage=29&rft.epage=33&rft.pages=29-33&rft.issn=0019-8366&rft.eissn=1880-8026&rft_id=info:doi/10.2486/indhealth.33.29&rft_dat=%3Cpubmed_cross%3E7591858%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/7591858&rfr_iscdi=true |