Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1H)-thiones
The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1 )-thione compounds using sodium hydroxide catalyzed three component condensation and cyclization reaction of substituted 6-methoxy-2-acetonapthone, various substituted benzaldehydes and...
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| Veröffentlicht in: | Analele Universității "Ovidius" Constanța. Seria Chimie 2024-01, Vol.35 (1), p.36-42 |
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| container_title | Analele Universității "Ovidius" Constanța. Seria Chimie |
| container_volume | 35 |
| creator | Venkatraman, Rajendran Divya, Jaganathan Gayathri, Pannerselvam Thirunarayanan, Ganesamoorthy Muthuvel, Inbasekaran |
| description | The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1
)-thione compounds using sodium hydroxide catalyzed three component condensation and cyclization reaction of substituted 6-methoxy-2-acetonapthone, various substituted benzaldehydes and thiourea. These thione derivatives were characterized by their analytical, physical, and spectroscopic data. In addition, the
antibacterial activities of these pyrimidine derivatives were evaluated using Bauer-Kirby disc diffusion method. |
| doi_str_mv | 10.2478/auoc-2024-0005 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 2286-038X |
| ispartof | Analele Universității "Ovidius" Constanța. Seria Chimie, 2024-01, Vol.35 (1), p.36-42 |
| issn | 2286-038X 2286-038X |
| language | eng |
| recordid | cdi_crossref_primary_10_2478_auoc_2024_0005 |
| source | Walter De Gruyter: Open Access Journals |
| subjects | acetonaphthones antibacterial activity NMR spectra pyrimidinethiones thiourea |
| title | Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1H)-thiones |
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