Molecular Mechanisms of Dentine-Pulp Complex Response Induced by Microbiome of Deep Caries

Molecular Mechanisms of Dentine-Pulp Complex Response Induced by Microbiome of Deep Caries

Deep caries progress is associated with tertiary dentin formation and additional reversible or irreversible dental pulp inflammation. It seems that some particular signs of pain in irreversible pulpitis are associated to a particular caries microflora. Streptococcus species, Parvimonas micra and Dia...

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Veröffentlicht in:Ars medica tomitana 2019-05, Vol.25 (2), p.53-60
Hauptverfasser: Alexandru-Andrei, Iliescu, Perlea, Paula, Irina-Maria, Gheorghiu, Mihai, Mitran, Loredana, Mitran, Iren, Moraru, Sînziana, Scărlătescu, Erdoğan, Șachir, Andrei, Iliescu
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container_title Ars medica tomitana
container_volume 25
creator Alexandru-Andrei, Iliescu
Perlea, Paula
Irina-Maria, Gheorghiu
Mihai, Mitran
Loredana, Mitran
Iren, Moraru
Sînziana, Scărlătescu
Erdoğan, Șachir
Andrei, Iliescu
description Deep caries progress is associated with tertiary dentin formation and additional reversible or irreversible dental pulp inflammation. It seems that some particular signs of pain in irreversible pulpitis are associated to a particular caries microflora. Streptococcus species, Parvimonas micra and Dialister invisus are prevailing in cases of throbbing pain while Streptococcus mutans is incriminated in sensitivity to vertical percussion of tooth. Continuous pain is thought to be the clinical outcome of Lactobacillus implication. A better understanding of molecular signals and mechanisms induced by microbiome of deep caries that orchestrate the modulation of dental pulp complex response toward tertiary dentinogenesis or pulp inflammation it is supposed to improve diagnosis and conservative therapies of vital pulp.
doi_str_mv 10.2478/arsm-2019-0012
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