Hepatic TORC2 Signaling Facilitates Acute Glucagon-Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

Long term glucagon receptor (GCGR) agonism is associated with hyperglycemia and glucose intolerance, while acute GCGR agonism enhances whole-body insulin sensitivity and hepatic AKTSer473 phosphorylation. These divergent effects establish a critical gap in knowledge surrounding GCGR action. mTOR Com...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-07
Hauptverfasser:	Kim, Teayoun, Nason, Shelly, Antipenko, Jessica, Finan, Brian, Shalev, Anath, DiMarchi, Richard, Habegger, Kirk M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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