Low Frequency of Ras Gene Mutation in Spontaneous and Gamma-Ray-Induced Thymic Lymphomas of Scid Mice

Scid mice, which have a defect in the capacity to repair DNA double-strand breaks, were highly prone to the induction of thymic lymphomas after exposure to ionizing radiation; ∼70% of mice developed lymphomas within 1 year after exposure to 1-3 Gy, whereas ∼20% of unirradiated control mice developed...

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