Enhanced Neoplastic Transformation in an Inhomogeneous Radiation Field: An Effect of the Presence of Heavily Damaged Cells
In the inhomogeneous radiation field surrounding small β-particle sources, nonlethally and heavily damaged cells are in proximity, permitting interaction via extracellular signals. This situation is typical of hot particles such as those released during the accident at Chernobyl. Beta-particle-emitt...
Gespeichert in:
| Veröffentlicht in: | Radiation research 1997-12, Vol.148 (6), p.543-547 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 547 |
|---|---|
| container_issue | 6 |
| container_start_page | 543 |
| container_title | Radiation research |
| container_volume | 148 |
| creator | Sigg, Martina Nigel E. A. Crompton Burkart, Werner |
| description | In the inhomogeneous radiation field surrounding small β-particle sources, nonlethally and heavily damaged cells are in proximity, permitting interaction via extracellular signals. This situation is typical of hot particles such as those released during the accident at Chernobyl. Beta-particle-emitting yttrium-90 wires (average energy 934 keV) were employed to investigate radiation-induced neoplastic transformation under these conditions. Integrated 24-h doses ranging from 0 to 750 Gy across the exposure field were applied. At equal levels of toxicity a 10-fold enhancement of neoplastic transformation frequency in C3H 10T1/2 cells was observed in the presence of heavily damaged cells. Homogeneous fields of low-dose-rate β-particle radiation produced neoplastic transformation frequencies typical for comparable photon exposures reported in the literature. |
| doi_str_mv | 10.2307/3579729 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_cross</sourceid><recordid>TN_cdi_crossref_primary_10_2307_3579729</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3579729</jstor_id><sourcerecordid>3579729</sourcerecordid><originalsourceid>FETCH-LOGICAL-c334t-132ad64688fcc8eddfba67ffae1bd08064c03b116cd41a9c61ec713bb12ad12b3</originalsourceid><addsrcrecordid>eNp1kMFKw0AQhhdRaq3iEwh7EDxFd7NpkvVWamsLRUXqOUx2Z9uUZLdkU6E-vSkN9eRp-Pm_mYGPkFvOHkPBkicxTGQSyjPS51KkwTBi0TnpMyZEkAzT5JJceb9hbeax7JGeFFLGUvbJz8SuwSrU9A3dtgTfFIoua7DeuLqCpnCWFpaCpXO7dpVboUW38_QTdHFspwWW-pmOLJ0Yg6qhztBmjfSjRo_t5UOeIXwX5Z6-QAWr9tcYy9JfkwsDpcebbg7I13SyHM-CxfvrfDxaBEqIqAm4CEHHUZymRqkUtTY5xIkxgDzXLGVxpJjIOY-VjjhIFXNUCRd5zts9HuZiQB6Od1XtvK_RZNu6qKDeZ5xlB3lZJ68l747kdpdXqE9cZ6vt77sevILStJpU4U9YyFLe2v_DNr5x9b_ffgFRV4Kh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Enhanced Neoplastic Transformation in an Inhomogeneous Radiation Field: An Effect of the Presence of Heavily Damaged Cells</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Sigg, Martina ; Nigel E. A. Crompton ; Burkart, Werner</creator><creatorcontrib>Sigg, Martina ; Nigel E. A. Crompton ; Burkart, Werner</creatorcontrib><description>In the inhomogeneous radiation field surrounding small β-particle sources, nonlethally and heavily damaged cells are in proximity, permitting interaction via extracellular signals. This situation is typical of hot particles such as those released during the accident at Chernobyl. Beta-particle-emitting yttrium-90 wires (average energy 934 keV) were employed to investigate radiation-induced neoplastic transformation under these conditions. Integrated 24-h doses ranging from 0 to 750 Gy across the exposure field were applied. At equal levels of toxicity a 10-fold enhancement of neoplastic transformation frequency in C3H 10T1/2 cells was observed in the presence of heavily damaged cells. Homogeneous fields of low-dose-rate β-particle radiation produced neoplastic transformation frequencies typical for comparable photon exposures reported in the literature.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3579729</identifier><identifier>PMID: 9399699</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Radiation Research Society</publisher><subject>Animals ; Beta Particles ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Cell culture techniques ; Cell Transformation, Neoplastic - radiation effects ; Cells, Cultured ; DNA Damage ; Epidermal cells ; Epithelial cells ; Female ; Irradiation ; Medical sciences ; Mice ; Mice, Inbred C3H ; Physical agents ; Radiation damage ; Radiation dosage ; Radiotherapy ; Solar X rays ; Tumors ; Yttrium</subject><ispartof>Radiation research, 1997-12, Vol.148 (6), p.543-547</ispartof><rights>Copyright 1997 The Radiation Research Society</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-132ad64688fcc8eddfba67ffae1bd08064c03b116cd41a9c61ec713bb12ad12b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3579729$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3579729$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2081193$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9399699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sigg, Martina</creatorcontrib><creatorcontrib>Nigel E. A. Crompton</creatorcontrib><creatorcontrib>Burkart, Werner</creatorcontrib><title>Enhanced Neoplastic Transformation in an Inhomogeneous Radiation Field: An Effect of the Presence of Heavily Damaged Cells</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>In the inhomogeneous radiation field surrounding small β-particle sources, nonlethally and heavily damaged cells are in proximity, permitting interaction via extracellular signals. This situation is typical of hot particles such as those released during the accident at Chernobyl. Beta-particle-emitting yttrium-90 wires (average energy 934 keV) were employed to investigate radiation-induced neoplastic transformation under these conditions. Integrated 24-h doses ranging from 0 to 750 Gy across the exposure field were applied. At equal levels of toxicity a 10-fold enhancement of neoplastic transformation frequency in C3H 10T1/2 cells was observed in the presence of heavily damaged cells. Homogeneous fields of low-dose-rate β-particle radiation produced neoplastic transformation frequencies typical for comparable photon exposures reported in the literature.</description><subject>Animals</subject><subject>Beta Particles</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Cell culture techniques</subject><subject>Cell Transformation, Neoplastic - radiation effects</subject><subject>Cells, Cultured</subject><subject>DNA Damage</subject><subject>Epidermal cells</subject><subject>Epithelial cells</subject><subject>Female</subject><subject>Irradiation</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Physical agents</subject><subject>Radiation damage</subject><subject>Radiation dosage</subject><subject>Radiotherapy</subject><subject>Solar X rays</subject><subject>Tumors</subject><subject>Yttrium</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFKw0AQhhdRaq3iEwh7EDxFd7NpkvVWamsLRUXqOUx2Z9uUZLdkU6E-vSkN9eRp-Pm_mYGPkFvOHkPBkicxTGQSyjPS51KkwTBi0TnpMyZEkAzT5JJceb9hbeax7JGeFFLGUvbJz8SuwSrU9A3dtgTfFIoua7DeuLqCpnCWFpaCpXO7dpVboUW38_QTdHFspwWW-pmOLJ0Yg6qhztBmjfSjRo_t5UOeIXwX5Z6-QAWr9tcYy9JfkwsDpcebbg7I13SyHM-CxfvrfDxaBEqIqAm4CEHHUZymRqkUtTY5xIkxgDzXLGVxpJjIOY-VjjhIFXNUCRd5zts9HuZiQB6Od1XtvK_RZNu6qKDeZ5xlB3lZJ68l747kdpdXqE9cZ6vt77sevILStJpU4U9YyFLe2v_DNr5x9b_ffgFRV4Kh</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Sigg, Martina</creator><creator>Nigel E. A. Crompton</creator><creator>Burkart, Werner</creator><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19971201</creationdate><title>Enhanced Neoplastic Transformation in an Inhomogeneous Radiation Field: An Effect of the Presence of Heavily Damaged Cells</title><author>Sigg, Martina ; Nigel E. A. Crompton ; Burkart, Werner</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-132ad64688fcc8eddfba67ffae1bd08064c03b116cd41a9c61ec713bb12ad12b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Beta Particles</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Cell culture techniques</topic><topic>Cell Transformation, Neoplastic - radiation effects</topic><topic>Cells, Cultured</topic><topic>DNA Damage</topic><topic>Epidermal cells</topic><topic>Epithelial cells</topic><topic>Female</topic><topic>Irradiation</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Physical agents</topic><topic>Radiation damage</topic><topic>Radiation dosage</topic><topic>Radiotherapy</topic><topic>Solar X rays</topic><topic>Tumors</topic><topic>Yttrium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sigg, Martina</creatorcontrib><creatorcontrib>Nigel E. A. Crompton</creatorcontrib><creatorcontrib>Burkart, Werner</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sigg, Martina</au><au>Nigel E. A. Crompton</au><au>Burkart, Werner</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Neoplastic Transformation in an Inhomogeneous Radiation Field: An Effect of the Presence of Heavily Damaged Cells</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>148</volume><issue>6</issue><spage>543</spage><epage>547</epage><pages>543-547</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>In the inhomogeneous radiation field surrounding small β-particle sources, nonlethally and heavily damaged cells are in proximity, permitting interaction via extracellular signals. This situation is typical of hot particles such as those released during the accident at Chernobyl. Beta-particle-emitting yttrium-90 wires (average energy 934 keV) were employed to investigate radiation-induced neoplastic transformation under these conditions. Integrated 24-h doses ranging from 0 to 750 Gy across the exposure field were applied. At equal levels of toxicity a 10-fold enhancement of neoplastic transformation frequency in C3H 10T1/2 cells was observed in the presence of heavily damaged cells. Homogeneous fields of low-dose-rate β-particle radiation produced neoplastic transformation frequencies typical for comparable photon exposures reported in the literature.</abstract><cop>Oak Brook, Il</cop><pub>Radiation Research Society</pub><pmid>9399699</pmid><doi>10.2307/3579729</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiation research, 1997-12, Vol.148 (6), p.543-547 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_2307_3579729 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Beta Particles Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell culture techniques Cell Transformation, Neoplastic - radiation effects Cells, Cultured DNA Damage Epidermal cells Epithelial cells Female Irradiation Medical sciences Mice Mice, Inbred C3H Physical agents Radiation damage Radiation dosage Radiotherapy Solar X rays Tumors Yttrium |
| title | Enhanced Neoplastic Transformation in an Inhomogeneous Radiation Field: An Effect of the Presence of Heavily Damaged Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T06%3A13%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enhanced%20Neoplastic%20Transformation%20in%20an%20Inhomogeneous%20Radiation%20Field:%20An%20Effect%20of%20the%20Presence%20of%20Heavily%20Damaged%20Cells&rft.jtitle=Radiation%20research&rft.au=Sigg,%20Martina&rft.date=1997-12-01&rft.volume=148&rft.issue=6&rft.spage=543&rft.epage=547&rft.pages=543-547&rft.issn=0033-7587&rft.eissn=1938-5404&rft.coden=RAREAE&rft_id=info:doi/10.2307/3579729&rft_dat=%3Cjstor_cross%3E3579729%3C/jstor_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/9399699&rft_jstor_id=3579729&rfr_iscdi=true |