Lung Cancer Risk due to Exposure to Incorporated Plutonium
An epidemiological study has been carried out among 1,479 male workers who started working at the "Mayak" Production Association in 1948-1958 and were exposed to external γ radiation and plutonium aerosols. Lung cancer mortality for the follow-up period 1948-1993 has been analyzed. No stat...
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| Veröffentlicht in: | Radiation research 1998-04, Vol.149 (4), p.366-371 |
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| creator | Koshurnikova, N. A. Bolotnikova, M. G. Ilyin, L. A. Keirim-Markus, I. B. Menshikh, Z. S. Okatenko, P. V. Romanov, S. A. Tsvetkov, V. I. Shilnikova, N. S. |
| description | An epidemiological study has been carried out among 1,479 male workers who started working at the "Mayak" Production Association in 1948-1958 and were exposed to external γ radiation and plutonium aerosols. Lung cancer mortality for the follow-up period 1948-1993 has been analyzed. No statistically significant association of lung cancer mortality and external γ-ray dose has been revealed in the range of accumulated doses of 0.2-5.5 Gy. Association of lung cancer mortality and the dose of α-particle radiation to the lung is statistically significant. In the dose range below 30 Sv, this association can be described in terms of a linear nonthreshold function. Lifetime lung cancer risk in the dose range below 30 Sv is $1.21\times 10^{-2}\ {\rm Sv}^{-1}$. |
| doi_str_mv | 10.2307/3579699 |
| format | Article |
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A. ; Bolotnikova, M. G. ; Ilyin, L. A. ; Keirim-Markus, I. B. ; Menshikh, Z. S. ; Okatenko, P. V. ; Romanov, S. A. ; Tsvetkov, V. I. ; Shilnikova, N. S.</creator><creatorcontrib>Koshurnikova, N. A. ; Bolotnikova, M. G. ; Ilyin, L. A. ; Keirim-Markus, I. B. ; Menshikh, Z. S. ; Okatenko, P. V. ; Romanov, S. A. ; Tsvetkov, V. I. ; Shilnikova, N. S.</creatorcontrib><description>An epidemiological study has been carried out among 1,479 male workers who started working at the "Mayak" Production Association in 1948-1958 and were exposed to external γ radiation and plutonium aerosols. Lung cancer mortality for the follow-up period 1948-1993 has been analyzed. No statistically significant association of lung cancer mortality and external γ-ray dose has been revealed in the range of accumulated doses of 0.2-5.5 Gy. Association of lung cancer mortality and the dose of α-particle radiation to the lung is statistically significant. In the dose range below 30 Sv, this association can be described in terms of a linear nonthreshold function. Lifetime lung cancer risk in the dose range below 30 Sv is $1.21\times 10^{-2}\ {\rm Sv}^{-1}$.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3579699</identifier><identifier>PMID: 9525501</identifier><language>eng</language><publisher>United States: Radiation Research Society</publisher><subject>Adult ; Aerosols ; Age Factors ; Aged ; Alpha Particles ; Body burden ; Dosage ; Dose response relationship ; Dose-Response Relationship, Radiation ; Gamma Rays ; Humans ; Life tables ; Lung neoplasms ; Lung Neoplasms - etiology ; Lung Neoplasms - mortality ; Lungs ; Male ; Middle Aged ; Mortality ; Neoplasms, Radiation-Induced ; Occupational Exposure ; Plutonium ; Radiation dosage ; Radiation dose response relationship ; Registries ; Risk</subject><ispartof>Radiation research, 1998-04, Vol.149 (4), p.366-371</ispartof><rights>Copyright 1998 The Radiation Research Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-b407beec6175a37016a15357b8d030bec005d944c0f65374ba79c91a745351043</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3579699$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3579699$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9525501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koshurnikova, N. 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Association of lung cancer mortality and the dose of α-particle radiation to the lung is statistically significant. In the dose range below 30 Sv, this association can be described in terms of a linear nonthreshold function. Lifetime lung cancer risk in the dose range below 30 Sv is $1.21\times 10^{-2}\ {\rm Sv}^{-1}$.</description><subject>Adult</subject><subject>Aerosols</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Alpha Particles</subject><subject>Body burden</subject><subject>Dosage</subject><subject>Dose response relationship</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Gamma Rays</subject><subject>Humans</subject><subject>Life tables</subject><subject>Lung neoplasms</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - mortality</subject><subject>Lungs</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasms, Radiation-Induced</subject><subject>Occupational Exposure</subject><subject>Plutonium</subject><subject>Radiation dosage</subject><subject>Radiation dose response relationship</subject><subject>Registries</subject><subject>Risk</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1j8FKxDAQhoMo67qKTyDkIHiqTjZJ03iTsupCQRE9lyRNpeu2KUkD-vZWW7x5mhn-j5_5EDoncL2mIG4oFzKV8gAtiaRZwhmwQ7QEoDQRPBPH6CSEHYw3SeUCLSRfcw5kiW6L2L3jXHXGevzShA9cRYsHhzefvQvR_-7bzjjfO68GW-HnfRxc18T2FB3Vah_s2TxX6O1-85o_JsXTwza_KxJDBRkSzUBoa01KBFdUAEkV4eO7OquAgrYGgFeSMQN1yqlgWglpJFGCjRQBRlfoauo13oXgbV32vmmV_yoJlD_y5Sw_khcT2Ufd2uqPm23H_HLKd2Fw_t-abyN2XQs</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Koshurnikova, N. 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A.</creatorcontrib><creatorcontrib>Bolotnikova, M. G.</creatorcontrib><creatorcontrib>Ilyin, L. A.</creatorcontrib><creatorcontrib>Keirim-Markus, I. B.</creatorcontrib><creatorcontrib>Menshikh, Z. S.</creatorcontrib><creatorcontrib>Okatenko, P. V.</creatorcontrib><creatorcontrib>Romanov, S. A.</creatorcontrib><creatorcontrib>Tsvetkov, V. I.</creatorcontrib><creatorcontrib>Shilnikova, N. S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koshurnikova, N. A.</au><au>Bolotnikova, M. G.</au><au>Ilyin, L. A.</au><au>Keirim-Markus, I. B.</au><au>Menshikh, Z. S.</au><au>Okatenko, P. V.</au><au>Romanov, S. A.</au><au>Tsvetkov, V. I.</au><au>Shilnikova, N. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung Cancer Risk due to Exposure to Incorporated Plutonium</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>149</volume><issue>4</issue><spage>366</spage><epage>371</epage><pages>366-371</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>An epidemiological study has been carried out among 1,479 male workers who started working at the "Mayak" Production Association in 1948-1958 and were exposed to external γ radiation and plutonium aerosols. Lung cancer mortality for the follow-up period 1948-1993 has been analyzed. No statistically significant association of lung cancer mortality and external γ-ray dose has been revealed in the range of accumulated doses of 0.2-5.5 Gy. Association of lung cancer mortality and the dose of α-particle radiation to the lung is statistically significant. In the dose range below 30 Sv, this association can be described in terms of a linear nonthreshold function. Lifetime lung cancer risk in the dose range below 30 Sv is $1.21\times 10^{-2}\ {\rm Sv}^{-1}$.</abstract><cop>United States</cop><pub>Radiation Research Society</pub><pmid>9525501</pmid><doi>10.2307/3579699</doi><tpages>6</tpages></addata></record> |
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| ispartof | Radiation research, 1998-04, Vol.149 (4), p.366-371 |
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| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Adult Aerosols Age Factors Aged Alpha Particles Body burden Dosage Dose response relationship Dose-Response Relationship, Radiation Gamma Rays Humans Life tables Lung neoplasms Lung Neoplasms - etiology Lung Neoplasms - mortality Lungs Male Middle Aged Mortality Neoplasms, Radiation-Induced Occupational Exposure Plutonium Radiation dosage Radiation dose response relationship Registries Risk |
| title | Lung Cancer Risk due to Exposure to Incorporated Plutonium |
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