Glycophorin A as a Biological Dosimeter for Radiation Dose to the Bone Marrow from Iodine-131
The frequency of peripheral blood erythrocyte variants exhibiting allelic loss of glycophorin A (N/M antigen) has been used previously as a biological dosimeter to assess somatic mutations in bone marrow cells from external whole-body irradiation. The aim of the present study was to determine whethe...
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| Veröffentlicht in: | Radiation Research 1997-06, Vol.147 (6), p.747-752 |
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| creator | Jensen, Ronald H. Reynolds, James C. Robbins, Jacob Bigbee, William L. Grant, Stephen G. Langlois, Richard G. Pineda, J. Desiree Lee, Taisheng Barker, W. Craig |
| description | The frequency of peripheral blood erythrocyte variants exhibiting allelic loss of glycophorin A (N/M antigen) has been used previously as a biological dosimeter to assess somatic mutations in bone marrow cells from external whole-body irradiation. The aim of the present study was to determine whether this marker could be used as a measure of bone marrow genotoxicity induced by 131 I in the treatment of thyroid cancer. Flow cytometry of immunolabeled erythrocytes was performed to enumerate glycophorin A variants before and after eight therapy doses of 131 I administered to five patients with differentiated thyroid carcinoma. Bone marrow radiation exposure from each dose was calculated from the integrated retention of 131 I in the whole body and in the blood. In addition, the accumulated dose to the bone marrow received from earlier 131 I therapy was calculated for each patient. Regression analysis was performed on the frequency of two glycophorin A variant cell types (N/Ø and N/N) as a function of accumulated dose to the bone marrow. Frequency of N/Ø variant cells showed a significant dose-related increase with a slope of $10.9\times 10^{-6}$ per sievert. This dose effect is about one-half that previously observed after whole-body external irradiation at high dose rate. This decreased response could be explained by the low dose rate of the radiation to the bone marrow from 131 I. |
| doi_str_mv | 10.2307/3579490 |
| format | Article |
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Desiree ; Lee, Taisheng ; Barker, W. Craig</creator><creatorcontrib>Jensen, Ronald H. ; Reynolds, James C. ; Robbins, Jacob ; Bigbee, William L. ; Grant, Stephen G. ; Langlois, Richard G. ; Pineda, J. Desiree ; Lee, Taisheng ; Barker, W. Craig</creatorcontrib><description>The frequency of peripheral blood erythrocyte variants exhibiting allelic loss of glycophorin A (N/M antigen) has been used previously as a biological dosimeter to assess somatic mutations in bone marrow cells from external whole-body irradiation. The aim of the present study was to determine whether this marker could be used as a measure of bone marrow genotoxicity induced by 131 I in the treatment of thyroid cancer. Flow cytometry of immunolabeled erythrocytes was performed to enumerate glycophorin A variants before and after eight therapy doses of 131 I administered to five patients with differentiated thyroid carcinoma. Bone marrow radiation exposure from each dose was calculated from the integrated retention of 131 I in the whole body and in the blood. In addition, the accumulated dose to the bone marrow received from earlier 131 I therapy was calculated for each patient. Regression analysis was performed on the frequency of two glycophorin A variant cell types (N/Ø and N/N) as a function of accumulated dose to the bone marrow. Frequency of N/Ø variant cells showed a significant dose-related increase with a slope of $10.9\times 10^{-6}$ per sievert. This dose effect is about one-half that previously observed after whole-body external irradiation at high dose rate. This decreased response could be explained by the low dose rate of the radiation to the bone marrow from 131 I.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3579490</identifier><identifier>PMID: 9189175</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Radiation Research Society</publisher><subject>Biological and medical sciences ; BIOLOGY AND MEDICINE, APPLIED STUDIES ; Blood ; Bone marrow ; Bone Marrow - radiation effects ; BONE MARROW CELLS ; Dose response relationship ; Dose-Response Relationship, Radiation ; DOSE-RESPONSE RELATIONSHIPS ; Dosimetry ; ERYTHROCYTES ; Female ; Glycophorin - pharmacology ; Humans ; IODINE 131 ; Iodine Radioisotopes - adverse effects ; Linear regression ; Male ; Medical sciences ; Nuclear medicine ; PATIENTS ; Radiation Dosage ; Radiation dose response relationship ; RADIATION DOSES ; Radiation therapy and radiosensitizing agent ; RADIOTHERAPY ; REGRESSION ANALYSIS ; SOMATIC MUTATIONS ; THYROID ; Thyroid cancer ; Thyroid Neoplasms - radiotherapy ; Treatment with physical agents ; Treatment. General aspects ; Tumors</subject><ispartof>Radiation Research, 1997-06, Vol.147 (6), p.747-752</ispartof><rights>Copyright 1997 The Radiation Research Society</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-a80abc8f61a5aeaee42f8b6e8bc40287f98446f4024ba3310fd9711214e906b93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3579490$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3579490$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,885,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2692818$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9189175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/535362$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Jensen, Ronald H.</creatorcontrib><creatorcontrib>Reynolds, James C.</creatorcontrib><creatorcontrib>Robbins, Jacob</creatorcontrib><creatorcontrib>Bigbee, William L.</creatorcontrib><creatorcontrib>Grant, Stephen G.</creatorcontrib><creatorcontrib>Langlois, Richard G.</creatorcontrib><creatorcontrib>Pineda, J. Desiree</creatorcontrib><creatorcontrib>Lee, Taisheng</creatorcontrib><creatorcontrib>Barker, W. Craig</creatorcontrib><title>Glycophorin A as a Biological Dosimeter for Radiation Dose to the Bone Marrow from Iodine-131</title><title>Radiation Research</title><addtitle>Radiat Res</addtitle><description>The frequency of peripheral blood erythrocyte variants exhibiting allelic loss of glycophorin A (N/M antigen) has been used previously as a biological dosimeter to assess somatic mutations in bone marrow cells from external whole-body irradiation. The aim of the present study was to determine whether this marker could be used as a measure of bone marrow genotoxicity induced by 131 I in the treatment of thyroid cancer. Flow cytometry of immunolabeled erythrocytes was performed to enumerate glycophorin A variants before and after eight therapy doses of 131 I administered to five patients with differentiated thyroid carcinoma. Bone marrow radiation exposure from each dose was calculated from the integrated retention of 131 I in the whole body and in the blood. In addition, the accumulated dose to the bone marrow received from earlier 131 I therapy was calculated for each patient. Regression analysis was performed on the frequency of two glycophorin A variant cell types (N/Ø and N/N) as a function of accumulated dose to the bone marrow. Frequency of N/Ø variant cells showed a significant dose-related increase with a slope of $10.9\times 10^{-6}$ per sievert. This dose effect is about one-half that previously observed after whole-body external irradiation at high dose rate. This decreased response could be explained by the low dose rate of the radiation to the bone marrow from 131 I.</description><subject>Biological and medical sciences</subject><subject>BIOLOGY AND MEDICINE, APPLIED STUDIES</subject><subject>Blood</subject><subject>Bone marrow</subject><subject>Bone Marrow - radiation effects</subject><subject>BONE MARROW CELLS</subject><subject>Dose response relationship</subject><subject>Dose-Response Relationship, Radiation</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>Dosimetry</subject><subject>ERYTHROCYTES</subject><subject>Female</subject><subject>Glycophorin - pharmacology</subject><subject>Humans</subject><subject>IODINE 131</subject><subject>Iodine Radioisotopes - adverse effects</subject><subject>Linear regression</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nuclear medicine</subject><subject>PATIENTS</subject><subject>Radiation Dosage</subject><subject>Radiation dose response relationship</subject><subject>RADIATION DOSES</subject><subject>Radiation therapy and radiosensitizing agent</subject><subject>RADIOTHERAPY</subject><subject>REGRESSION ANALYSIS</subject><subject>SOMATIC MUTATIONS</subject><subject>THYROID</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - radiotherapy</subject><subject>Treatment with physical agents</subject><subject>Treatment. General aspects</subject><subject>Tumors</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMoc07xFwgRBK-qSZO2yeU2dQ4mguillNM0cRldM5KI7N_bsTKvvDof78M58CB0Scldykhxz7JCckmO0JBKJpKME36MhoQwlhSZKE7RWQgr0s00lwM0kFRIWmRD9Dlrtsptls7bFo8xBAx4Yl3jvqyCBj-4YNc6ao-N8_gNagvRuna31zg6HJcaT1yr8Qt4736w8W6N5662rU4oo-foxEAT9EVfR-jj6fF9-pwsXmfz6XiRKJaTmIAgUClhcgoZaNCap0ZUuRaV4iQVhZGC89x0Pa-AMUpMLQtKU8q1JHkl2Qhd7--6EG0ZlI1aLZVrW61imbGM5WnH3O4Z5V0IXpty4-0a_LakpNw5LHuHHXm1Jzff1VrXB66X1uU3fQ6hk2Q8tMqGA5bmMhVU_GGrEJ3_99svnnyBWA</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>Jensen, Ronald H.</creator><creator>Reynolds, James C.</creator><creator>Robbins, Jacob</creator><creator>Bigbee, William L.</creator><creator>Grant, Stephen G.</creator><creator>Langlois, Richard G.</creator><creator>Pineda, J. Desiree</creator><creator>Lee, Taisheng</creator><creator>Barker, W. Craig</creator><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19970601</creationdate><title>Glycophorin A as a Biological Dosimeter for Radiation Dose to the Bone Marrow from Iodine-131</title><author>Jensen, Ronald H. ; Reynolds, James C. ; Robbins, Jacob ; Bigbee, William L. ; Grant, Stephen G. ; Langlois, Richard G. ; Pineda, J. Desiree ; Lee, Taisheng ; Barker, W. Craig</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-a80abc8f61a5aeaee42f8b6e8bc40287f98446f4024ba3310fd9711214e906b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>BIOLOGY AND MEDICINE, APPLIED STUDIES</topic><topic>Blood</topic><topic>Bone marrow</topic><topic>Bone Marrow - radiation effects</topic><topic>BONE MARROW CELLS</topic><topic>Dose response relationship</topic><topic>Dose-Response Relationship, Radiation</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>Dosimetry</topic><topic>ERYTHROCYTES</topic><topic>Female</topic><topic>Glycophorin - pharmacology</topic><topic>Humans</topic><topic>IODINE 131</topic><topic>Iodine Radioisotopes - adverse effects</topic><topic>Linear regression</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nuclear medicine</topic><topic>PATIENTS</topic><topic>Radiation Dosage</topic><topic>Radiation dose response relationship</topic><topic>RADIATION DOSES</topic><topic>Radiation therapy and radiosensitizing agent</topic><topic>RADIOTHERAPY</topic><topic>REGRESSION ANALYSIS</topic><topic>SOMATIC MUTATIONS</topic><topic>THYROID</topic><topic>Thyroid cancer</topic><topic>Thyroid Neoplasms - radiotherapy</topic><topic>Treatment with physical agents</topic><topic>Treatment. General aspects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, Ronald H.</creatorcontrib><creatorcontrib>Reynolds, James C.</creatorcontrib><creatorcontrib>Robbins, Jacob</creatorcontrib><creatorcontrib>Bigbee, William L.</creatorcontrib><creatorcontrib>Grant, Stephen G.</creatorcontrib><creatorcontrib>Langlois, Richard G.</creatorcontrib><creatorcontrib>Pineda, J. Desiree</creatorcontrib><creatorcontrib>Lee, Taisheng</creatorcontrib><creatorcontrib>Barker, W. Craig</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiation Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, Ronald H.</au><au>Reynolds, James C.</au><au>Robbins, Jacob</au><au>Bigbee, William L.</au><au>Grant, Stephen G.</au><au>Langlois, Richard G.</au><au>Pineda, J. Desiree</au><au>Lee, Taisheng</au><au>Barker, W. Craig</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycophorin A as a Biological Dosimeter for Radiation Dose to the Bone Marrow from Iodine-131</atitle><jtitle>Radiation Research</jtitle><addtitle>Radiat Res</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>147</volume><issue>6</issue><spage>747</spage><epage>752</epage><pages>747-752</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>The frequency of peripheral blood erythrocyte variants exhibiting allelic loss of glycophorin A (N/M antigen) has been used previously as a biological dosimeter to assess somatic mutations in bone marrow cells from external whole-body irradiation. The aim of the present study was to determine whether this marker could be used as a measure of bone marrow genotoxicity induced by 131 I in the treatment of thyroid cancer. Flow cytometry of immunolabeled erythrocytes was performed to enumerate glycophorin A variants before and after eight therapy doses of 131 I administered to five patients with differentiated thyroid carcinoma. Bone marrow radiation exposure from each dose was calculated from the integrated retention of 131 I in the whole body and in the blood. In addition, the accumulated dose to the bone marrow received from earlier 131 I therapy was calculated for each patient. Regression analysis was performed on the frequency of two glycophorin A variant cell types (N/Ø and N/N) as a function of accumulated dose to the bone marrow. Frequency of N/Ø variant cells showed a significant dose-related increase with a slope of $10.9\times 10^{-6}$ per sievert. This dose effect is about one-half that previously observed after whole-body external irradiation at high dose rate. This decreased response could be explained by the low dose rate of the radiation to the bone marrow from 131 I.</abstract><cop>Oak Brook, Il</cop><pub>Radiation Research Society</pub><pmid>9189175</pmid><doi>10.2307/3579490</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiation Research, 1997-06, Vol.147 (6), p.747-752 |
| issn | 0033-7587 1938-5404 |
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| subjects | Biological and medical sciences BIOLOGY AND MEDICINE, APPLIED STUDIES Blood Bone marrow Bone Marrow - radiation effects BONE MARROW CELLS Dose response relationship Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS Dosimetry ERYTHROCYTES Female Glycophorin - pharmacology Humans IODINE 131 Iodine Radioisotopes - adverse effects Linear regression Male Medical sciences Nuclear medicine PATIENTS Radiation Dosage Radiation dose response relationship RADIATION DOSES Radiation therapy and radiosensitizing agent RADIOTHERAPY REGRESSION ANALYSIS SOMATIC MUTATIONS THYROID Thyroid cancer Thyroid Neoplasms - radiotherapy Treatment with physical agents Treatment. General aspects Tumors |
| title | Glycophorin A as a Biological Dosimeter for Radiation Dose to the Bone Marrow from Iodine-131 |
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