In Vitro Action of Continuous-Wave Ultrasound Combined with Adriamycin, X Rays or Hyperthermia
We compared the ability of continuous-wave ultrasound to enhance cytotoxicity from X irradiation, hyperthermia or exposure to adriamycin. The survival of CHO cells exposed in culture medium to these agents was determined with and without continuous-wave ultrasound (1.62 or 1.765 MHz). In water-fille...
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| Veröffentlicht in: | Radiation Research 1996-01, Vol.145 (1), p.98-101 |
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| creator | Harrison, George H. Balcer-Kubiczek, Elizabeth K. Gutierrez, Peter L. |
| description | We compared the ability of continuous-wave ultrasound to enhance cytotoxicity from X irradiation, hyperthermia or exposure to adriamycin. The survival of CHO cells exposed in culture medium to these agents was determined with and without continuous-wave ultrasound (1.62 or 1.765 MHz). In water-filled transmission exposure vessels with 2-cm-diameter Mylar end windows, 10-min insonation not producing cytotoxicity could produce ^{\bullet}{\rm OH}$ radicals (measured by electron paramagnetic resonance) even at $0.4\ {\rm W}/{\rm cm}^{2}$. Ultrasound at intensities ranging between 1 and $2.5\ {\rm W}/{\rm cm}^{2}$ increased the clonogenic cytotoxicity of adriamycin (P = 0.0023 by paired t test) but not of X rays (2-10 Gy) or hyperthermia (44°C for 10-50 min). The only significant action of continuous-wave ultrasound under similar test conditions was the potentiation of adriamycin-induced clonogenic cytotoxicity, possibly mediated by cavitational activity. |
| doi_str_mv | 10.2307/3579202 |
| format | Article |
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The survival of CHO cells exposed in culture medium to these agents was determined with and without continuous-wave ultrasound (1.62 or 1.765 MHz). In water-filled transmission exposure vessels with 2-cm-diameter Mylar end windows, 10-min insonation not producing cytotoxicity could produce ^{\bullet}{\rm OH}$ radicals (measured by electron paramagnetic resonance) even at $0.4\ {\rm W}/{\rm cm}^{2}$. Ultrasound at intensities ranging between 1 and $2.5\ {\rm W}/{\rm cm}^{2}$ increased the clonogenic cytotoxicity of adriamycin (P = 0.0023 by paired t test) but not of X rays (2-10 Gy) or hyperthermia (44°C for 10-50 min). The only significant action of continuous-wave ultrasound under similar test conditions was the potentiation of adriamycin-induced clonogenic cytotoxicity, possibly mediated by cavitational activity.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3579202</identifier><identifier>PMID: 8532844</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Radiation Research Society</publisher><subject>Animals ; Antibiotics, Antineoplastic - toxicity ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BIOLOGY AND MEDICINE, APPLIED STUDIES ; BIOLOGY AND MEDICINE, BASIC STUDIES ; Cell Survival - drug effects ; Cell Survival - physiology ; Cell Survival - radiation effects ; CHEMOTHERAPY ; CHO CELLS ; COMBINED THERAPY ; Cricetinae ; Cultured cells ; Cytotoxicity ; Dose-Response Relationship, Radiation ; DOXORUBICIN ; Doxorubicin - toxicity ; Effects of various physical factors on living matter (vibrations, electric field, ultrasound, sound...) ; Electron Spin Resonance Spectroscopy ; Flasks ; Free radicals ; Fundamental and applied biological sciences. Psychology ; Hot Temperature ; Hydroxyl Radical - analysis ; Hydroxyl Radical - metabolism ; HYPERTHERMIA ; Hyperthermia, Induced ; Irradiation ; Kinetics ; NEOPLASMS ; RADIOTHERAPY ; Solar X rays ; Tissues, organs and organisms biophysics ; TOXICITY ; Transducers ; ULTRASONOGRAPHY ; X RADIATION ; X-Rays</subject><ispartof>Radiation Research, 1996-01, Vol.145 (1), p.98-101</ispartof><rights>Copyright 1996 The Radiation Research Society</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-4f943d481d85b7c67afceef59c32e1ffad8dbe6a587beec0a556b616eefcff323</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3579202$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3579202$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,885,4024,27923,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3043971$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8532844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/478305$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Harrison, George H.</creatorcontrib><creatorcontrib>Balcer-Kubiczek, Elizabeth K.</creatorcontrib><creatorcontrib>Gutierrez, Peter L.</creatorcontrib><title>In Vitro Action of Continuous-Wave Ultrasound Combined with Adriamycin, X Rays or Hyperthermia</title><title>Radiation Research</title><addtitle>Radiat Res</addtitle><description>We compared the ability of continuous-wave ultrasound to enhance cytotoxicity from X irradiation, hyperthermia or exposure to adriamycin. The survival of CHO cells exposed in culture medium to these agents was determined with and without continuous-wave ultrasound (1.62 or 1.765 MHz). In water-filled transmission exposure vessels with 2-cm-diameter Mylar end windows, 10-min insonation not producing cytotoxicity could produce ^{\bullet}{\rm OH}$ radicals (measured by electron paramagnetic resonance) even at $0.4\ {\rm W}/{\rm cm}^{2}$. Ultrasound at intensities ranging between 1 and $2.5\ {\rm W}/{\rm cm}^{2}$ increased the clonogenic cytotoxicity of adriamycin (P = 0.0023 by paired t test) but not of X rays (2-10 Gy) or hyperthermia (44°C for 10-50 min). The only significant action of continuous-wave ultrasound under similar test conditions was the potentiation of adriamycin-induced clonogenic cytotoxicity, possibly mediated by cavitational activity.</description><subject>Animals</subject><subject>Antibiotics, Antineoplastic - toxicity</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BIOLOGY AND MEDICINE, APPLIED STUDIES</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - physiology</subject><subject>Cell Survival - radiation effects</subject><subject>CHEMOTHERAPY</subject><subject>CHO CELLS</subject><subject>COMBINED THERAPY</subject><subject>Cricetinae</subject><subject>Cultured cells</subject><subject>Cytotoxicity</subject><subject>Dose-Response Relationship, Radiation</subject><subject>DOXORUBICIN</subject><subject>Doxorubicin - toxicity</subject><subject>Effects of various physical factors on living matter (vibrations, electric field, ultrasound, sound...)</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Flasks</subject><subject>Free radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hot Temperature</subject><subject>Hydroxyl Radical - analysis</subject><subject>Hydroxyl Radical - metabolism</subject><subject>HYPERTHERMIA</subject><subject>Hyperthermia, Induced</subject><subject>Irradiation</subject><subject>Kinetics</subject><subject>NEOPLASMS</subject><subject>RADIOTHERAPY</subject><subject>Solar X rays</subject><subject>Tissues, organs and organisms biophysics</subject><subject>TOXICITY</subject><subject>Transducers</subject><subject>ULTRASONOGRAPHY</subject><subject>X RADIATION</subject><subject>X-Rays</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10NFKwzAUBuAgypxTfAIhguCN1aRJ2vRyDHWDgSBOvbKkacIiazKSVOnbW1mZV16Fw_9xDvkBOMfoNiUovyMsL1KUHoAxLghPGEX0EIwRIiTJGc-PwUkIn6ifcVaMwIgzknJKx-BjYeGrid7BqYzGWeg0nDkbjW1dG5I38aXgahO9CK61dR81lbGqht8mruG09kY0nTT2Br7DZ9EF6Dycd1vl41r5xohTcKTFJqiz4Z2A1cP9y2yeLJ8eF7PpMpEkQzGhuqCkphzXnFW5zHKhpVKaFZKkCmstal5XKhP9TyqlJBKMZVWGs95IrUlKJuByt9eFaMogTVRyLZ21SsaS5pwg1pvrnZHeheCVLrfeNMJ3JUblb4nlUGIvL3Zy21aNqvduaK3Pr4ZcBCk22gsrTdgzgigpcvzHPkN0_t9rPyIahLQ</recordid><startdate>19960101</startdate><enddate>19960101</enddate><creator>Harrison, George H.</creator><creator>Balcer-Kubiczek, Elizabeth K.</creator><creator>Gutierrez, Peter L.</creator><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19960101</creationdate><title>In Vitro Action of Continuous-Wave Ultrasound Combined with Adriamycin, X Rays or Hyperthermia</title><author>Harrison, George H. ; Balcer-Kubiczek, Elizabeth K. ; Gutierrez, Peter L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-4f943d481d85b7c67afceef59c32e1ffad8dbe6a587beec0a556b616eefcff323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Antibiotics, Antineoplastic - toxicity</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BIOLOGY AND MEDICINE, APPLIED STUDIES</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - physiology</topic><topic>Cell Survival - radiation effects</topic><topic>CHEMOTHERAPY</topic><topic>CHO CELLS</topic><topic>COMBINED THERAPY</topic><topic>Cricetinae</topic><topic>Cultured cells</topic><topic>Cytotoxicity</topic><topic>Dose-Response Relationship, Radiation</topic><topic>DOXORUBICIN</topic><topic>Doxorubicin - toxicity</topic><topic>Effects of various physical factors on living matter (vibrations, electric field, ultrasound, sound...)</topic><topic>Electron Spin Resonance Spectroscopy</topic><topic>Flasks</topic><topic>Free radicals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hot Temperature</topic><topic>Hydroxyl Radical - analysis</topic><topic>Hydroxyl Radical - metabolism</topic><topic>HYPERTHERMIA</topic><topic>Hyperthermia, Induced</topic><topic>Irradiation</topic><topic>Kinetics</topic><topic>NEOPLASMS</topic><topic>RADIOTHERAPY</topic><topic>Solar X rays</topic><topic>Tissues, organs and organisms biophysics</topic><topic>TOXICITY</topic><topic>Transducers</topic><topic>ULTRASONOGRAPHY</topic><topic>X RADIATION</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harrison, George H.</creatorcontrib><creatorcontrib>Balcer-Kubiczek, Elizabeth K.</creatorcontrib><creatorcontrib>Gutierrez, Peter L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiation Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harrison, George H.</au><au>Balcer-Kubiczek, Elizabeth K.</au><au>Gutierrez, Peter L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Action of Continuous-Wave Ultrasound Combined with Adriamycin, X Rays or Hyperthermia</atitle><jtitle>Radiation Research</jtitle><addtitle>Radiat Res</addtitle><date>1996-01-01</date><risdate>1996</risdate><volume>145</volume><issue>1</issue><spage>98</spage><epage>101</epage><pages>98-101</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>We compared the ability of continuous-wave ultrasound to enhance cytotoxicity from X irradiation, hyperthermia or exposure to adriamycin. The survival of CHO cells exposed in culture medium to these agents was determined with and without continuous-wave ultrasound (1.62 or 1.765 MHz). In water-filled transmission exposure vessels with 2-cm-diameter Mylar end windows, 10-min insonation not producing cytotoxicity could produce ^{\bullet}{\rm OH}$ radicals (measured by electron paramagnetic resonance) even at $0.4\ {\rm W}/{\rm cm}^{2}$. Ultrasound at intensities ranging between 1 and $2.5\ {\rm W}/{\rm cm}^{2}$ increased the clonogenic cytotoxicity of adriamycin (P = 0.0023 by paired t test) but not of X rays (2-10 Gy) or hyperthermia (44°C for 10-50 min). The only significant action of continuous-wave ultrasound under similar test conditions was the potentiation of adriamycin-induced clonogenic cytotoxicity, possibly mediated by cavitational activity.</abstract><cop>Oak Brook, Il</cop><pub>Radiation Research Society</pub><pmid>8532844</pmid><doi>10.2307/3579202</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Antibiotics, Antineoplastic - toxicity Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BIOLOGY AND MEDICINE, APPLIED STUDIES BIOLOGY AND MEDICINE, BASIC STUDIES Cell Survival - drug effects Cell Survival - physiology Cell Survival - radiation effects CHEMOTHERAPY CHO CELLS COMBINED THERAPY Cricetinae Cultured cells Cytotoxicity Dose-Response Relationship, Radiation DOXORUBICIN Doxorubicin - toxicity Effects of various physical factors on living matter (vibrations, electric field, ultrasound, sound...) Electron Spin Resonance Spectroscopy Flasks Free radicals Fundamental and applied biological sciences. Psychology Hot Temperature Hydroxyl Radical - analysis Hydroxyl Radical - metabolism HYPERTHERMIA Hyperthermia, Induced Irradiation Kinetics NEOPLASMS RADIOTHERAPY Solar X rays Tissues, organs and organisms biophysics TOXICITY Transducers ULTRASONOGRAPHY X RADIATION X-Rays |
| title | In Vitro Action of Continuous-Wave Ultrasound Combined with Adriamycin, X Rays or Hyperthermia |
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