Analysis of the K-ras and p53 Pathways in X-Ray-Induced Lung Tumors in the Rat

The risk from exposure to low-dose radiation in conjunction with cigarette smoking has not been estimated due in part to limited knowledge surrounding the molecular mechanisms underlying radiation-induced cancers. The purpose of this investigation was to determine the frequency for alterations in ge...

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Veröffentlicht in:	Radiation Research 1996-04, Vol.145 (4), p.449-456
Hauptverfasser:	Belinsky, Steven A., Middleton, Susan K., Picksley, Steven M., Hahn, Fletcher F., Nikula, Kristen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - etiology Adenocarcinoma - genetics Amino Acid Sequence Animal tumors. Experimental tumors Animals Base Sequence Biological and medical sciences Biological effects of radiation BIOLOGICAL PATHWAYS BIOLOGY AND MEDICINE, APPLIED STUDIES Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - genetics CARCINOMAS Cell lines Codons Cyclin-Dependent Kinase Inhibitor p21 Cyclins - genetics DNA Primers - chemistry Exons Experimental respiratory system tumors Female Fundamental and applied biological sciences. Psychology Gene Amplification GENES Genes, p53 Genes, ras Genetic mutation GENETIC RADIATION EFFECTS Humans Ionizing radiations Lung Neoplasms - etiology Lung Neoplasms - genetics LUNGS Male Medical sciences Mice Molecular Sequence Data Neoplasms, Radiation-Induced - genetics Nuclear Proteins Oncogenes Polymerase chain reaction Protein-Serine-Threonine Kinases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-mdm2 Proto-Oncogene Proteins c-raf Proto-Oncogene Proteins p21(ras) - genetics RADIOINDUCTION ras genes RATS Rats, Inbred F344 Sequence Alignment Sequence Homology, Amino Acid Solar X rays SOMATIC MUTATIONS Tissues, organs and organisms biophysics Tumor Suppressor Protein p53 - metabolism Tumors X-Rays
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