Chromosome Aberrations Produced by Radiation: The Relationship between Excess Acentric Fragments and Dicentrics

Most chromosome aberrations produced by ionizing radiation develop from DNA double-strand breaks (DSBs). Published data on the yield and variance of excess acentric fragments after in vitro irradiation of human lymphocytes were compared with corresponding data on dicentrics. At low LET the number of...

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Veröffentlicht in:	Radiation Research 1995-02, Vol.141 (2), p.136-152
Hauptverfasser:	Hahnfeldt, Philip, Hlatky, Lynn R., Brenner, David J., Sachs, Rainer K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences BIOLOGY AND MEDICINE, APPLIED STUDIES CHROMOSOMAL ABERRATIONS Chromosome Aberrations Chromosomes Chromosomes, Human - radiation effects COMPARATIVE EVALUATIONS Datasets DNA Dose response relationship Dose-Response Relationship, Radiation Fundamental and applied biological sciences. Psychology Humans IRRADIATION KINETICS LET LYMPHOCYTES Lymphocytes - radiation effects Models, Biological Molecular and cellular biology Molecular genetics Mutagenesis. Repair Radiation dosage Radiotherapy Ratios Statistical variance STRAND BREAKS VARIATIONS YIELDS
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