Chromosome Aberrations Produced by Radiation: The Relationship between Excess Acentric Fragments and Dicentrics
Most chromosome aberrations produced by ionizing radiation develop from DNA double-strand breaks (DSBs). Published data on the yield and variance of excess acentric fragments after in vitro irradiation of human lymphocytes were compared with corresponding data on dicentrics. At low LET the number of...
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| Veröffentlicht in: | Radiation Research 1995-02, Vol.141 (2), p.136-152 |
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| creator | Hahnfeldt, Philip Hlatky, Lynn R. Brenner, David J. Sachs, Rainer K. |
| description | Most chromosome aberrations produced by ionizing radiation develop from DNA double-strand breaks (DSBs). Published data on the yield and variance of excess acentric fragments after in vitro irradiation of human lymphocytes were compared with corresponding data on dicentrics. At low LET the number of excess acentric fragments is about 60% of the number of dicentrics, independent of dose and perhaps of dose rate, suggesting that dicentrics and excess acentric fragments arise from similar kinetics rather than from fundamentally different reactions. Only a weak dependence of the ratio on LET is observed. These results are quantified using generalizations of models for pairwise DSB interactions suggested by Brewen and Brock based on data for marsupial cells. By allowing singly incomplete and some "doubly incomplete" exchanges, the models can also account for the experimental observation that the dispersion for excess acentric fragments, a measure of cell-to-cell variance, is systematically larger than the dispersion for dicentrics. Numerical estimates of an incompleteness parameter are derived. |
| doi_str_mv | 10.2307/3579041 |
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Published data on the yield and variance of excess acentric fragments after in vitro irradiation of human lymphocytes were compared with corresponding data on dicentrics. At low LET the number of excess acentric fragments is about 60% of the number of dicentrics, independent of dose and perhaps of dose rate, suggesting that dicentrics and excess acentric fragments arise from similar kinetics rather than from fundamentally different reactions. Only a weak dependence of the ratio on LET is observed. These results are quantified using generalizations of models for pairwise DSB interactions suggested by Brewen and Brock based on data for marsupial cells. By allowing singly incomplete and some "doubly incomplete" exchanges, the models can also account for the experimental observation that the dispersion for excess acentric fragments, a measure of cell-to-cell variance, is systematically larger than the dispersion for dicentrics. Numerical estimates of an incompleteness parameter are derived.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3579041</identifier><identifier>PMID: 7838952</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Radiation Research Society</publisher><subject>Biological and medical sciences ; BIOLOGY AND MEDICINE, APPLIED STUDIES ; CHROMOSOMAL ABERRATIONS ; Chromosome Aberrations ; Chromosomes ; Chromosomes, Human - radiation effects ; COMPARATIVE EVALUATIONS ; Datasets ; DNA ; Dose response relationship ; Dose-Response Relationship, Radiation ; Fundamental and applied biological sciences. Psychology ; Humans ; IRRADIATION ; KINETICS ; LET ; LYMPHOCYTES ; Lymphocytes - radiation effects ; Models, Biological ; Molecular and cellular biology ; Molecular genetics ; Mutagenesis. Repair ; Radiation dosage ; Radiotherapy ; Ratios ; Statistical variance ; STRAND BREAKS ; VARIATIONS ; YIELDS</subject><ispartof>Radiation Research, 1995-02, Vol.141 (2), p.136-152</ispartof><rights>Copyright 1995 The Radiation Research Society</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-6c1b76f335dc4aad4da116f9422a101d99a77958daaca9e52046c4bcfc9c05063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3579041$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3579041$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3404542$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7838952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/68616$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Hahnfeldt, Philip</creatorcontrib><creatorcontrib>Hlatky, Lynn R.</creatorcontrib><creatorcontrib>Brenner, David J.</creatorcontrib><creatorcontrib>Sachs, Rainer K.</creatorcontrib><title>Chromosome Aberrations Produced by Radiation: The Relationship between Excess Acentric Fragments and Dicentrics</title><title>Radiation Research</title><addtitle>Radiat Res</addtitle><description>Most chromosome aberrations produced by ionizing radiation develop from DNA double-strand breaks (DSBs). Published data on the yield and variance of excess acentric fragments after in vitro irradiation of human lymphocytes were compared with corresponding data on dicentrics. At low LET the number of excess acentric fragments is about 60% of the number of dicentrics, independent of dose and perhaps of dose rate, suggesting that dicentrics and excess acentric fragments arise from similar kinetics rather than from fundamentally different reactions. Only a weak dependence of the ratio on LET is observed. These results are quantified using generalizations of models for pairwise DSB interactions suggested by Brewen and Brock based on data for marsupial cells. By allowing singly incomplete and some "doubly incomplete" exchanges, the models can also account for the experimental observation that the dispersion for excess acentric fragments, a measure of cell-to-cell variance, is systematically larger than the dispersion for dicentrics. Numerical estimates of an incompleteness parameter are derived.</description><subject>Biological and medical sciences</subject><subject>BIOLOGY AND MEDICINE, APPLIED STUDIES</subject><subject>CHROMOSOMAL ABERRATIONS</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes</subject><subject>Chromosomes, Human - radiation effects</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>Datasets</subject><subject>DNA</subject><subject>Dose response relationship</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>IRRADIATION</subject><subject>KINETICS</subject><subject>LET</subject><subject>LYMPHOCYTES</subject><subject>Lymphocytes - radiation effects</subject><subject>Models, Biological</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Mutagenesis. Repair</subject><subject>Radiation dosage</subject><subject>Radiotherapy</subject><subject>Ratios</subject><subject>Statistical variance</subject><subject>STRAND BREAKS</subject><subject>VARIATIONS</subject><subject>YIELDS</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9LxDAQxYMo67qKn0DIQfBUTZqkbbwt619YUETPZTpJ3SzbZkkq6re365bFi6eZee_HDLwh5JSzy1Sw_EqoXDPJ98iYa1EkSjK5T8aMCZHkqsgPyVGMS9bPPNMjMsoLUWiVjomfLYJvfPSNpdPKhgCd822kz8GbD7SGVt_0BYz7la_p68LSF7vaQgu3ppXtPq1t6e0X2hjpFG3bBYf0LsB70_eRQmvojRv0eEwOalhFezLUCXm7u32dPSTzp_vH2XSeoExVl2TIqzyrhVAGJYCRBjjPai3TFDjjRmvIc60KA4CgrUqZzFBWWKNGplgmJoRu9_rYuTKi6ywu0Letxa7MioxvkIstgsHHGGxdroNrIHyXnJWbUMsh1J4825Lrj6qxZscNKfb--eBDRFjVAVp0cYeJ_hlK_sGWsfPh32s_CvOKIg</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>Hahnfeldt, Philip</creator><creator>Hlatky, Lynn R.</creator><creator>Brenner, David J.</creator><creator>Sachs, Rainer K.</creator><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19950201</creationdate><title>Chromosome Aberrations Produced by Radiation: The Relationship between Excess Acentric Fragments and Dicentrics</title><author>Hahnfeldt, Philip ; Hlatky, Lynn R. ; Brenner, David J. ; Sachs, Rainer K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-6c1b76f335dc4aad4da116f9422a101d99a77958daaca9e52046c4bcfc9c05063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biological and medical sciences</topic><topic>BIOLOGY AND MEDICINE, APPLIED STUDIES</topic><topic>CHROMOSOMAL ABERRATIONS</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes</topic><topic>Chromosomes, Human - radiation effects</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>Datasets</topic><topic>DNA</topic><topic>Dose response relationship</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>IRRADIATION</topic><topic>KINETICS</topic><topic>LET</topic><topic>LYMPHOCYTES</topic><topic>Lymphocytes - radiation effects</topic><topic>Models, Biological</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Mutagenesis. Repair</topic><topic>Radiation dosage</topic><topic>Radiotherapy</topic><topic>Ratios</topic><topic>Statistical variance</topic><topic>STRAND BREAKS</topic><topic>VARIATIONS</topic><topic>YIELDS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hahnfeldt, Philip</creatorcontrib><creatorcontrib>Hlatky, Lynn R.</creatorcontrib><creatorcontrib>Brenner, David J.</creatorcontrib><creatorcontrib>Sachs, Rainer K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiation Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hahnfeldt, Philip</au><au>Hlatky, Lynn R.</au><au>Brenner, David J.</au><au>Sachs, Rainer K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosome Aberrations Produced by Radiation: The Relationship between Excess Acentric Fragments and Dicentrics</atitle><jtitle>Radiation Research</jtitle><addtitle>Radiat Res</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>141</volume><issue>2</issue><spage>136</spage><epage>152</epage><pages>136-152</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>Most chromosome aberrations produced by ionizing radiation develop from DNA double-strand breaks (DSBs). Published data on the yield and variance of excess acentric fragments after in vitro irradiation of human lymphocytes were compared with corresponding data on dicentrics. At low LET the number of excess acentric fragments is about 60% of the number of dicentrics, independent of dose and perhaps of dose rate, suggesting that dicentrics and excess acentric fragments arise from similar kinetics rather than from fundamentally different reactions. Only a weak dependence of the ratio on LET is observed. These results are quantified using generalizations of models for pairwise DSB interactions suggested by Brewen and Brock based on data for marsupial cells. By allowing singly incomplete and some "doubly incomplete" exchanges, the models can also account for the experimental observation that the dispersion for excess acentric fragments, a measure of cell-to-cell variance, is systematically larger than the dispersion for dicentrics. Numerical estimates of an incompleteness parameter are derived.</abstract><cop>Oak Brook, Il</cop><pub>Radiation Research Society</pub><pmid>7838952</pmid><doi>10.2307/3579041</doi><tpages>17</tpages></addata></record> |
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| ispartof | Radiation Research, 1995-02, Vol.141 (2), p.136-152 |
| issn | 0033-7587 1938-5404 |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Biological and medical sciences BIOLOGY AND MEDICINE, APPLIED STUDIES CHROMOSOMAL ABERRATIONS Chromosome Aberrations Chromosomes Chromosomes, Human - radiation effects COMPARATIVE EVALUATIONS Datasets DNA Dose response relationship Dose-Response Relationship, Radiation Fundamental and applied biological sciences. Psychology Humans IRRADIATION KINETICS LET LYMPHOCYTES Lymphocytes - radiation effects Models, Biological Molecular and cellular biology Molecular genetics Mutagenesis. Repair Radiation dosage Radiotherapy Ratios Statistical variance STRAND BREAKS VARIATIONS YIELDS |
| title | Chromosome Aberrations Produced by Radiation: The Relationship between Excess Acentric Fragments and Dicentrics |
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